Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Skin and Connective Tissue Diseases

Symptoms and General Pathology

Digestive System Diseases

Gland and Hormone Related Diseases

Rare Diseases

Lung Neoplasms

Prostatic Neoplasms

Breast Neoplasms

Weight Loss

Pancreatic Neoplasms

Melanoma

Carcinoma, Renal Cell

Liver Neoplasms

Body Weight

Melanoma, Cutaneous Malignant

Kidney Neoplasms

Endometrial Neoplasms

Urogenital Neoplasms

Genital Diseases

Urogenital Diseases

Male Urogenital Diseases

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Uterine Neoplasms

Genital Neoplasms, Female

Uterine Diseases

Genital Diseases, Female

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urologic Neoplasms

Kidney Diseases

Urologic Diseases

Pancreatic Cancer

Renal Cell Carcinoma

Neuroendocrine Tumor

Neuroepithelioma

Hypoglycemic Agents

All Drugs and Chemicals

Central Nervous System Depressants

Other Dietary Supplements

Insulin

Insulin, Globin Zinc

Metformin

Mitogens

Benzocaine

Tannic Acid

In this group, the study staff will meet with you once at the beginning of the study to give you written information about weight management.

The Remote Lifestyle Coaching intervention is based on the Call Center Directed intervention to help you loss weight

This group will be given the study drug called Metformin. Metformin comes in tablet form that you take with meals

Participants will receive metformin, an oral medication for type 2 diabetes.Participants randomized to the metformin intervention will receive metformin up to 2,000 mg per day.Dosing can be flexible, two or three times per day with meals as tolerated for 12 months.

Behavioral-based telephonic coaching with web-based support to promote healthy lifestyle and weight loss in overweight and obese adults.The goal of this intervention is to achieve at least 5% weight loss in the first six months of the intervention and maintain these improvements through month twelve by meeting dietary and exercise goals

Coach Directed Behavioral Weight Loss

Self-control weight loss

Jessica Yeh, PhD

This is a prospective, single-center randomized trial with three arms, and an allocation ratio of 1:1:1. The study design is an efficacy study to evaluate the effect of metformin and coach-directed behavioral weight loss versus self-directed weight loss on insulin-like growth factor (IGF)-1 and IGF-1 to THE IGFBP-III ratio blood levels after 6 and 12 months of intervention. The coach-directed Behavioral Weight Loss arm is a web-based remote delivery and communication system that promotes healthy behavioral changes. The Metformin arm is a pharmaceutical intervention of oral metformin. This is a secondary prevention study for men and women who have survived solid malignant tumors

Survivorship Promotion In Reducing IGF-1 Trial

Trial of Behavioral Weight Loss and Metformin Treatment to Lower Insulin Growth Factor in Cancer Survivors

Changes in weight among Metformin group, or coach-directed Groups versus the self-directed arm at 6 and 12 months

Changes in BMI among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in EuroQol score among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in dietary intake among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in physical activity amount among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in fasting glucose among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in insulin among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in Hb-A1C among Metformin arm, or Coach-directed behavioral weight loss arm versus the Self-control weight loss arm at 6 and 12 months.

Changes in IL-6 among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in IL-8 among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Changes in CRP among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

assessing side effect among Metformin arm, or coach-directed behavioral weight loss arm versus the self-directed arm at 6 and 12 months.

Insulin-like growth factor (IGF)-1 levels (ng/ml) at 6 months.

IGF-1 level to IGFBP3 level ratio (molar ratio) at 6 months.

Maryland Cigarette Restitution Fund

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

In this group, the study staff will meet with you once at the beginning of the study to give you written information about weight management.

Self-control weight loss

Self-Directed

The Remote Lifestyle Coaching intervention is based on the Call Center Directed intervention to help you loss weight

Coach Directed Behavioral Weight Loss: Behavioral-based telephonic coaching with web-based support to promote healthy lifestyle and weight loss in overweight and obese adults.The goal of this intervention is to achieve at least 5% weight loss in the first six months of the intervention and maintain these improvements through month twelve by meeting dietary and exercise goals

This group will be given the study drug called Metformin. Metformin comes in tablet form that you take with meals

Metformin: Participants will receive metformin, an oral medication for type 2 diabetes.Participants randomized to the metformin intervention will receive metformin up to 2,000 mg per day.Dosing can be flexible, two or three times per day with meals as tolerated for 12 months.

Total

Age, Continuous

Sex: Female, Male

Black

Others

Race/Ethnicity, Customized

Dr. Jessica Yeh

IGF-1 Levels

Data was obtained for 39 participants in the self-directed arm, 37 in the coach directed arm and 37 in the metformin arm for this outcome measure.

Data was obtained for 39 participants in the self-directed arm, 37 in the coach directed arm and 36 in the metformin arm for this outcome measure.

Spots Global Cancer Trial Database for coach directed behavioral weight loss