Neoplasms

Symptoms and General Pathology

All Conditions

Digestive System Diseases

Neoplasm Metastasis

Recurrence

Colorectal Neoplasms

Appendiceal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Cecal Neoplasms

Cecal Diseases

prospective single arm biomarker (plasma cell-free DNA hydroxymethylation) study

Bruce Bissonnette, MD

Patients with peritoneal metastasis of colorectal or high grade appendiceal origin who are candidates for cytoreductive surgery with HIPEC (hyperthermic intraperitoneal chemotherapy) will be enrolled in this study. Blood collection for measurements of plasma cell-free DNA hydroxymethylation signatures will be performed at different time points, before and after surgery, in order to determine if plasma hydroxymethylation signatures are more sensitive than conventional tumor markers in identifying clinically detectable recurrence at 1 year after surgery.

This will be a prospective single arm biomarker (plasma-free DNA 5-hydroxymethylation) study. Fifty-five Adult patients with peritoneal metastases of colorectal and appendiceal origin who are candidates for a curative surgery and fulfill the inclusion criteria will be offered to participate in this study. In addition to the postoperative standard of care oncological surveillance of these patients which includes periodic physical examinations, cross sectional imaging studies (CT or MRI) and blood work for conventional tumor markers, serial measurements of plasma hydroxymethylation signatures will be performed. We will use a model developed in a separate pilot study to identify recurrent peritoneal metastasis based on 5hmC signatures. As part of this study, blood collection for measurements of plasma hydroxymethylation signatures of target genes will be performed at seven time points:

* Just before surgery (During the preoperative clinic visit or at the operating room).
* 5-7 days after surgery (just before hospital discharge).
* 6 weeks after surgery (first postoperative clinic visit).
* 3 months after surgery (second postoperative clinic visit).
* 6 months after surgery (third postoperative clinic visit).
* 9 months after surgery (fourth postoperative clinic visit).
* 12 months after surgery (fifth postoperative clinic visit). Standard of care surveillance elements that include patient history and physical examination, conventional blood biomarkers (CEA, CA 19-9 and CA 125) and cross sectional imaging of the chest, abdomen and pelvis will be undertaken simultaneously at similar time points. We will then compare the sensitivities of DNA hydroxymethylation signatures and conventional blood biomarkers in diagnosing clinically detectable recurrence at 1 year after surgery. We hypothesize that plasma hydroxymethylation signatures have higher sensitivity in identifying clinically detectable recurrence when compared with conventional tumor markers (CEA, CA 19-9 and CA 125).

Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

5-hydroxymethylation Signatures in Plasma Circulating Cell-free DNA as Markers for Tumor Burden and Recurrence in Appendiceal and Colorectal Peritoneal Metastasis

1. Clear radiological evidence of recurrent disease.
2. Histopathological proof (by means of endoscopy, imaging guided biopsy or diagnostic surgery) of recurrent disease.
3. A new lesion revealed by physical examination

University of Chicago

Herbal and Botanical

All Drugs and Chemicals

Cola

An exploration with a COLON CAPSULE ENDOSCOPY eaten which capsule has a video-camera in both end to see the colon.

COLON CAPSULE ENDOSCOPY ADHERENCE

An exploration with an OPTICAL COLONOSCOPY from the anus to see the colon.

OPTICAL COLONOSCOPY ADHERENCE

Enrique Quintero, MD. PhD.

The purpose of this study is to determine if the adherence to screening in first grade relatives of patients with CCR is higher than optical colonoscopy.

The purpose of this study is to compare the adherence and effectiveness of colon capsule endoscopy (CCE-2) versus conventional colonoscopy to screen first-degree relatives of patients with colorectal cancer.

Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population

Effectiveness of Colon Capsule Endoscopy as Colorectal Cancer Method of Screening in The Familiar-Risk Population

Assess whether colon capsule endoscopy increases participation to colorectal cancer screening in first-degree relatives of patients with colorectal cancer

Hospital Universitario de Canarias

Inflammatory Bowel Diseases

Gastroenteritis

transcriptomic analysis on preserved tumor tissue

transcriptomic analysis

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

Transcriptomic Study of IBD-associated Colorectal Cancer

Transcriptiomic Analysis of Inflammatory Bowel Disease-associated Colorectal Cancer. A French Retrospective Study of 26 Cases Identified at the Nancy University Hospital

Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis	NCT04157322	Colorectal Canc... Colorectal Canc... Colorectal Canc... Appendix Cancer	prospective sin...	18 Years -	University of Chicago
Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population	NCT01557101	Colorectal Canc...	COLON CAPSULE E... OPTICAL COLONOS...	40 Years - 65 Years	Hospital Universitario de Canarias
Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population	NCT01557101	Colorectal Canc...	COLON CAPSULE E... OPTICAL COLONOS...	40 Years - 65 Years	Hospital Universitario de Canarias
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis	NCT04157322	Colorectal Canc... Colorectal Canc... Colorectal Canc... Appendix Cancer	prospective sin...	18 Years -	University of Chicago
Transcriptomic Study of IBD-associated Colorectal Cancer	NCT05060770	Colorectal Canc...	transcriptomic ...	18 Years - 100 Years	Central Hospital, Nancy, France
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis	NCT04157322	Colorectal Canc... Colorectal Canc... Colorectal Canc... Appendix Cancer	prospective sin...	18 Years -	University of Chicago
Transcriptomic Study of IBD-associated Colorectal Cancer	NCT05060770	Colorectal Canc...	transcriptomic ...	18 Years - 100 Years	Central Hospital, Nancy, France
Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population	NCT01557101	Colorectal Canc...	COLON CAPSULE E... OPTICAL COLONOS...	40 Years - 65 Years	Hospital Universitario de Canarias

Spots Global Cancer Trial Database for colorectal cancer, genetics of