Digestive System Diseases

All Conditions

Neoplasms

Symptoms and General Pathology

Colitis

Adenoma

Dysbiosis

Colitis, Microscopic

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Gastroenteritis

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Herbal and Botanical

All Drugs and Chemicals

Cola

Endoscopic exploration of the colon (colonoscopy) for standard clinical practice (study of chronic watery diarrhoea, treatment of colon adenomas or population screening with a positive faecal occult blood test)

Colonoscopy

Yamile Zabana, MD, PhD

Microscopic colitis (MC) is an inflammatory bowel disease characterized by chronic non-bloody watery diarrhoea and a macroscopically normal colonic mucosa upon endoscopic exploration (colonoscopy). The diagnosis is performed by microscopic examination of mucosal biopsies that reveal specific histopathological change. Between 4-20% of patients with chronic non-bloody diarrhoea who undergo colonoscopy with serial biopsies are diagnosed with MC.

It has long been hypothesized that the microbiome plays a key role in the pathogenesis of MC. In patients with collagenous colitis, faecal stream diversion results in inflammation and histological remission, followed by disease relapse after intestinal transit is reconstructed. Moreover, studies carried out with faecal samples obtained after colonoscopy have demonstrated microbiome changes (reduced alpha diversity and higher microbial dysbiosis index) in patients with active MC. To avoid potential bias due to the effect of colonic lavage prior to colonoscopy in microbiota composition, the researchers of the present study previously evaluated the microbiome in faecal samples obtained before the diagnostic colonoscopy in patients with active MC. The results confirmed a reduced alpha diversity in diarrhoea groups; however, there were no differences between MC, bile-acid diarrhoea and functional diarrhoea. The microbial dysbiosis index was significantly higher in MC compared to the other diarrheal groups, but no bacterial species showed a significantly different relative abundance. On the other hand, the risk of colorectal cancer (CRC) or adenoma seems to be reduced in MC compared to controls. Growing evidence suggests microbial dysbiosis is a crucial environmental factor in the initiation of precancerous lesions of CRC such as adenomas.

The objective of the current multicentric prospective study is to assess the differences in the mucosa adherent intestinal microbiome between patients with MC, non-MC chronic diarrhoea, healthy controls and patients with advanced colon adenomas. In addition to the study of the microbiome, sociodemographic variables, history of drug usage, diets and specific characteristics of diarrhoea will be collected.

The hypothesis of the present study is that CM presents a specific mucosa adherent intestinal bacterial profile that may be relevant in the pathogenesis of the disease and that, additionally, may also play a protective role against the development of CRC and adenomas.

Mucosa Adherent Intestinal Microbiome in Microscopic Colitis and Colorectal Cancer

Intestinal Microbiome Adherent to the Mucosa in Microscopic Colitis in Comparison With Patients With Advanced Colon Adenomas

Hospital Mutua de Terrassa

Nutritional and Metabolic Diseases

Blood and Lymph Conditions

Immune System Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Stomach Neoplasms

Syndrome

Esophageal Neoplasms

Obesity

Irritable Bowel Syndrome

Crohn Disease

Gastroesophageal Reflux

Colonic Polyps

Colitis, Ulcerative

Ulcer

Gallstones

Cholelithiasis

Cholecystolithiasis

Celiac Disease

Polyps

Esophagitis

Eosinophilic Esophagitis

Barrett Esophagus

Metaplasia

Gastritis

Stomach Ulcer

Duodenal Ulcer

Colitis, Lymphocytic

Stomach Diseases

Inflammatory Bowel Diseases

Esophageal Diseases

Colonic Diseases, Functional

Precancerous Conditions

Eosinophilia

Leukocyte Disorders

Hematologic Diseases

Hypersensitivity

Hypersensitivity, Immediate

Biliary Tract Diseases

Gallbladder Diseases

Calculi

Pathological Conditions, Anatomical

Esophageal Motility Disorders

Esophageal Spasm, Diffuse

Deglutition Disorders

Peptic Ulcer

Duodenal Diseases

Malabsorption Syndromes

Metabolic Diseases

Stomach Cancer

Esophageal Cancer

Eosinophilic Gastroenteritis

Hematinics

Liver Extracts

Participants with Eosinophilic esophagitis

Participants with Gastroesophageal Reflux Disease (GERD).

Participants with intestinal metaplasia (risk factor for esophageal cancer).

Participants with Lymphocytic/Microscopic Colitis.

Momchilo Vuyisich

This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and remissions, or progression of their disease.

This is a longitudinal, observational study whose main goal is to identify the human and microbial determinants of gastrointestinal diseases. Molecular and metadata will be collected from a large study population at multiple time points. Machine learning will be applied to all data, and models will be evaluated for development of novel diagnostic and therapeutic tools.

Systems Biology of Gastrointestinal and Related Diseases

Identification of biomarkers that indicate gastrointestinal diseases.

Identification of microbial species that indicate gastrointestinal disease.

Prediction of the efficacy of a biologic medication against IBD based on molecular data and metadata.

Development of a molecular test for C. difficile infection (CDI)

Quantification of changes observed in the microbiome post colonoscopy.

Viome

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Mucosa Adherent Intestinal Microbiome in Microscopic Colitis and Colorectal Cancer	NCT06172647	Microscopic Col... Colorectal Canc... Colon Adenoma	Colonoscopy	45 Years -	Hospital Mutua de Terrassa
Systems Biology of Gastrointestinal and Related Diseases	NCT05579444	Ulcerative Coli... Crohn Disease Obesity Colon Polyp Eosinophilic Es... GERD Gastro Esophage... Barrett Esophag... Esophageal Canc... Gastritis Gastric Ulcer Duodenal Ulcer Intestinal Meta... Gastric Cancer Lymphocytic Col... Microscopic Col... Celiac Sprue IBS Irritable Bowel... SIBO NAFLD Gallstone Disea...		18 Years -	Viome
Systems Biology of Gastrointestinal and Related Diseases	NCT05579444	Ulcerative Coli... Crohn Disease Obesity Colon Polyp Eosinophilic Es... GERD Gastro Esophage... Barrett Esophag... Esophageal Canc... Gastritis Gastric Ulcer Duodenal Ulcer Intestinal Meta... Gastric Cancer Lymphocytic Col... Microscopic Col... Celiac Sprue IBS Irritable Bowel... SIBO NAFLD Gallstone Disea...		18 Years -	Viome

Spots Global Cancer Trial Database for microscopic colitis