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Tyrosine Kinase Inhibitors

Omega 3 Fatty Acid

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Olive

Placebo Comparator: Placebo All subjects will be given placebo identically matched with regard to shape, color and taste. They will be given four tablet/day for four mounths.

All subjects will be given fish oil with a dose of 2.100 mg of EPA and 924 mg of DHA, in four tablet twice daily for four mounths.

Drug: Placebo olive oil pill manufactured to mimic fish oil. Other Names: • Placebo

Placebo

All subjects will be given fish oil with a dose of of 2.100 mg of EPA and 924 mg of DHA, in four tablet twice daily for four mounths.

Fish oil

Wilza AF Peres, PhD

Imanuely B Gonçalves, MsC

This study is conducted to test the hypothesis that patients with lung cancer undergoing treatment with immunotherapy, chemotherapy and tyrosine Kinase Inhibitors receiving a high protein diet and supplemented with fish oil will improve muscle mass, therapeutic response and modulate the intestinal microbiota within a 4 month period.

Lung cancer (PC) is the most prevalent tumor. The loss of muscle mass, myosteatosis and changes in body composition have been associated with inflammation in cancer and PUFA n-3 have been shown to be an important modulator of the inflammatory response and epigenetic mechanisms. Additionally, the intestinal microbiome has received prominence with the use of immunotherapy, as it is demonstrating that resistance to this therapy can be attributed to the abnormal composition of the intestinal microbiome. Aims: The purpose of this study is to assess the effects of fish oil supplementation in the modulation of lean mass and intestinal microbiome in patients with lung cancer undergoing treatment with immunotherapy, chemotherapy and Tyrosine Kinase Inhibitors receiving a high-protein diet. Methods: Fifty patients will be randomly allocated either to treatment with fish oil or to placebo for 4 months. The following assessments will be made: lean mass, myosteatosis, sarcopenia, adipose compartment, inflammation, micro RNA, food consumption, membrane phospholipid composition, composition of the intestinal microbiota, toxicity, response to antineoplastic treatment and survival.

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet

Effect of Supplementation of Poly-unsaturated n-3 Fatty Acids and High-protein Diet on Epigenetic Modulation of Muscle Mass, Dose-limiting Toxicity and Intestinal Microbiota in Patients With Lung Cancer Submitted to Treatment With Immunotherapy, Chemotherapy and Tyrosine Kinase Inhibitors.

CT-derived changes in muscle mass ocurring from baseline to week 16

alpha- and beta-diversity of 16S bacterial rDNA

Measure the plasma levels of miRNA 133 from baseline to week 16 by real-time PCR

To assess the change/maintenance in muscle density from baseline to week 16 using computed tomography (CT).

Institutos Madrileño de Estudios Avanzados IMDEA

Oncoclínicas

Universidade Federal do Rio de Janeiro

Associate professor, Institute of Nutrition

Digestive System Diseases

Symptoms and General Pathology

Wounds and Injuries

Rare Diseases

Stomach Neoplasms

Hyperthermia

Fever

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Stomach Cancer

Micronutrients

Vitamins

The patients in this group were treated with omega-3 fish oil fat emulsion at a dose of 100ml/ per person per day for 5 days and added to a three-liter bag (containing water, glucose, amino acids, sodium chloride, vitamins, etc.) except fish oil.

Drug introduction:

Full name: omega-3 fish oil fat emulsion. Common name: Juventus. Specification: 100ml / 10g

Do not use omega-3 fish oil fat emulsion (no omega-3 fish oil fat emulsion is added to the three-liter bag, other substances are the same)

Omega-3 fish oil fat emulsion

Liu Ruiqing, Doctor

Wang Dongsheng, Doctor

The purpose of this study was to investigate the effects of omega-3 fish oil fat emulsion on peripheral blood C-reactive protein, total lymphocyte count, plasma albumin and immune function after radical surgery combined with intraperitoneal hyperthermic perfusion chemotherapy in patients with locally advanced gastric cancer. at the same time, to explore the effects of omega-3 fish oil fat emulsion on complications, length of stay and total cost of hospitalization.

The main question it aims to answer is whether the use of omega-3 fish oil fat emulsion can improve patients' immunity, speed up recovery and reduce costs.

Participants will comprehensively collect patient-related baseline data, including sex, age, BMI, ASA grade, tumor location, histological grade, pathological tumor type, pTNM stage (AJCC cancer stage 8), and perilymphatic vascular / nerve infiltration.

Immune function evaluation related index: peripheral blood lymphocyte count. Plasma albumin concentration, C-reactive protein, postoperative infectious complications, length of stay and cost of hospitalization.

Finally, statistical analysis software was used to analyze the differences between the two groups, evaluate the above indicators and draw mutual conclusions.

The research process is as follows:

1. Select patients in the group according to the inclusion and exclusion criteria.
2. The patient signed the informed consent form
3. His system was used to collect patient data, including human-related baseline data, including sex, age, BMI, ASA grade, tumor location, histological grade, pathological tumor type, pTNM stage (AJCC cancer stage 8th edition), lymphatic vascular / nerve infiltration. Immune function evaluation related index: peripheral blood lymphocyte count. Plasma albumin concentration, C-reactive protein, postoperative infectious complications, length of stay and cost of hospitalization.
4. Using statistical software (SPSS) to judge the statistical difference.
5. It is concluded that the use value of omega-3 fish oil fat emulsion (Ewing) is evaluated.

Effects of Omega-3 Fish Oil Fat Emulsion on Rehabilitation and Immune Function After Radical Surgery Combined With Intraperitoneal Hyperthermic Infusion Chemotherapy in Patients With Locally Advanced Gastric Cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet	NCT04965129	Lung Cancer	Placebo Fish oil	20 Years - 90 Years	Universidade Federal do Rio de Janeiro
Effects of Omega-3 Fish Oil Fat Emulsion on Rehabilitation and Immune Function After Radical Surgery Combined With Intraperitoneal Hyperthermic Infusion Chemotherapy in Patients With Locally Advanced Gastric Cancer	NCT06047158	Fish Oils Perfusion; Comp... Stomach Neoplas... Nutrition Aspec... Chemotherapy Ef... Immunisation Re...	Omega-3 fish oi...	18 Years - 75 Years	The Affiliated Hospital of Qingdao University
Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet	NCT04965129	Lung Cancer	Placebo Fish oil	20 Years - 90 Years	Universidade Federal do Rio de Janeiro
Effects of Omega-3 Fish Oil Fat Emulsion on Rehabilitation and Immune Function After Radical Surgery Combined With Intraperitoneal Hyperthermic Infusion Chemotherapy in Patients With Locally Advanced Gastric Cancer	NCT06047158	Fish Oils Perfusion; Comp... Stomach Neoplas... Nutrition Aspec... Chemotherapy Ef... Immunisation Re...	Omega-3 fish oi...	18 Years - 75 Years	The Affiliated Hospital of Qingdao University
Supplementation of n-3 PUFA in the Modulation of Lean Mass in Patients With Lung Cancer Receiving a High-protein Diet	NCT04965129	Lung Cancer	Placebo Fish oil	20 Years - 90 Years	Universidade Federal do Rio de Janeiro

Spots Global Cancer Trial Database for fish oils

Every month we try and update this database with for fish oils cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for fish oils

Every month we try and update this database with for fish oils cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for fish oils cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.