Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Digestive System Diseases

Gland and Hormone Related Diseases

Symptoms and General Pathology

Nutritional and Metabolic Diseases

Rare Diseases

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Pancreatic Neoplasms

Lung Diseases

Lung Diseases, Obstructive

Pulmonary Disease, Chronic Obstructive

Chronic Disease

Wasting Syndrome

Cachexia

Syndrome

Respiratory Tract Diseases

Disease Attributes

Weight Loss

Body Weight

Body Weight Changes

Thinness

Metabolic Diseases

Nutrition Disorders

Chronic Graft Versus Host Disease

Pancreatic Cancer

Acute Graft Versus Host Disease

Cachectic cancer patients, including non-small cell lung cancer (NSCLC) and gastro-intestinal cancer. The study participants will undergo fMRI scanning.

Non-cachectic cancer patients, including NSCLC and gastro-intestinal cancer. The study participants will undergo Functional magnetic resonance imaging (fMRI) scanning.

Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The study participants will undergo fMRI scanning.

Diagnosis of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The study participants will undergo fMRI scanning.

The food-cue elicited response in the reward-circuitry of the brain will be assessed by using fMRI. This technique is based on different magnetic properties of oxygenated and deoxygenated blood. Increased neuronal activity causes an increase in blood flow. Thereby, neuronal activity is indirectly reflected by changes in blood oxygenation level-dependent (BOLD) contrast.

Functional magnetic resonance imaging (fMRI)

Karin Sanders, MD

Judith de Vos-Geelen, MD

Annemie Schols, PhD

To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.

The activity in the food reward-circuitry of the brain in patients suffering from cachexia induced by cancer (lung cancer or pancreatic cancer) or chronic disease (chronic obstructive pulmonary disease) will be analysed by using functional magnetic resonance imaging. In addition, the role of the peripheral satiety hormones will be evaluated.

Food Reward in Cachexia Induced by Acute or Chronic Disease

Analysis of Food Reward System in Cachexia Induced by Acute or Chronic Disease

Maastricht University Medical Center

Esophageal Neoplasms

Weight Gain

Esophageal Cancer

All Drugs and Chemicals

Psychotropic Drugs

Antineoplastic Agents

Gastrointestinal Agents

Central Nervous System Depressants

Hormones

Somatostatin

Antidepressive Agents

Octreotide

Mirtazapine

This cohort will be the group who are undergoing routine clinical treatment with a long-acting somatostatin analogue to minimise abnormal gut hormone signalling, and thus reduce early satiety.

This cohort will be the group who are undergoing routine clinical treatment with a tetracyclic antidepressant to stimulate appetite.

Patients undergo clinical treatment as indicated, they are studied before and after.

Clinical treatment

The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this pathway responds to clinical treatment for this unintentional weight loss. The primary outcomes are the blood oxygen level dependent (BOLD) signal on functional MRI (fMRI), and the breakpoint during the progressive ratio task (PRT - a measure of eating behaviour), how these differ in response to multiple clinical treatment options, as well as how they relate to weight gain while on treatment.

The incidence of cancer of the oesophagus (food pipe) is increasing. Improvements in treatment strategies have resulted in more people who remain free from cancer recurrence in the long term following treatment.

Surgery is the cornerstone of treatment for patients with oesophageal cancer, but while surgical removal of the tumour (oesophagectomy) may offer the best chance of cure, these are major operations associated with specific long term complications. Poor appetite, weight loss and nutritional impairment are common problems among patients who attain long-term cancer remission and cure after surgery.

A new clinic has been established to treat patients who are in remission but who have lost more than 10% of their body weight secondary to the effects of the surgery and struggling to regain weight. These patients will be treated as per standard of care with medications to aid weight gain.

The investigators are interested to conduct research into how the reward value of food changes during the clinical treatment pathway. The hypothesis is that there will be an increased reward response to food after medication use, the magnitude of which will correlate with weight gain. To assess this, patients who are already part of this clinic will be approached to have fMRI that can demonstrate changes in brain reward centres as well as a Progressive Ratio Task, which is a direct measure of appetitive behaviour. Changes in brain reward centre responses and appetitive behaviour will be correlated with changes in weight after pharmacotherapy. This may further inform future clinical protocols to provide improved precision medicine.

Resection of the Esophagus and Subsequent Weight Loss

The Effect of Clinical Treatment for Unintentional Weight Loss on Food Reward and Appetitive Behaviour in Patients Who Have Lost >10% of Their Body Weight After Undergoing Curative Surgery for Oesophageal Cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Food Reward in Cachexia Induced by Acute or Chronic Disease	NCT02798003	Cachexia Chronic Obstruc... Non-small Cell ... Pancreatic Canc...	Functional magn...	18 Years -	Maastricht University Medical Center
Food Reward in Cachexia Induced by Acute or Chronic Disease	NCT02798003	Cachexia Chronic Obstruc... Non-small Cell ... Pancreatic Canc...	Functional magn...	18 Years -	Maastricht University Medical Center
Resection of the Esophagus and Subsequent Weight Loss	NCT03377660	Esophageal Canc... Weight Gain Eating Behavior Food Reward	Clinical treatm...	18 Years -	Imperial College London

Spots Global Cancer Trial Database for food reward

Every month we try and update this database with for food reward cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for food reward

Every month we try and update this database with for food reward cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for food reward cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.