Nervous System Diseases

Symptoms and General Pathology

All Conditions

Neoplasms

Hemiplegia

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Paralysis

Neurologic Manifestations

Two focused rigidity bi-valve long arm (upper arm to finger tips) casts will be fabricated for each participant on day one of the constraint-induced therapy (CIT) program. Focused rigidity casting materials are water proof and latex/fiberglass free. Focused rigidity casting does not require use of a cast saw for removal thus decreasing potential for anxiety during the casting process. Casts will be fabricated by therapist trained in the casting technique.

Focused rigidity bi-valve long arm cast

Jessica Sparrow, OTD, OTR/L

Hemiplegia (weakness or poor muscle function on one side of the body) is a neurological impairment which can occur in children as a result of a brain tumor or related treatment. This impairment can negatively impact the child's functional abilities and movement development, making it difficult for them to play, learn to feed, dress or bathe themselves, and to participate fully in home, daycare, or school environments. Poor movement skills may also impact overall quality of life. Constraint Induced Therapy is a rehabilitation technique which has been found to improve the child's abilities to move their arms following neurological injuries like stroke and traumatic brain injury in both adults and children.

The aim of this study is to evaluate the feasibility of implementing a constraint induced movement therapy program in a small group of children with a brain tumor and hemiplegia. Children who participate in the program may experience improved ability to use their weak arm leading to increased participation in meaningful activity and improved quality of life.

Constraint Induced Therapy (CI Therapy) is based on the theory of "learned non-use." Following an event that impacts the brain (stroke, brain injury etc.), the messages from the brain to the arm and the messages from the arm to the brain are interrupted in the area of the brain where the injury occurred and in a small surrounding area. The arm is often inefficient and difficult to use. Over time, even after swelling in the brain decreases, movement of the affected arm continues to be more effortful and the child becomes quite accustomed to completing activities with the unaffected arm only. Additionally, because the child has not used the weak arm for a while, the part of the brain that is ready to receive signals and give commands to the arm or leg is "quiet" and does not work like it used to. The theory of "learned no-nuse" has lead to the development of the CI Therapy approach which is comprised of the following principles:

* Constraint - the strong or normal arm/leg is restrained, forcing use of the weaker arm/leg during treatment.
* Practiced Use - the weak limb is treated by engaging the child in structured practice of specific movements and functional skills.
* Transfer Package - a home program is developed for the child to use with his or her caregivers that focuses on facilitating carryover of learned skills into the real world environment.

This theory hypothesizes that, because the nervous system, particularly in the child, has plasticity (can be shaped and learn to do new things), CI Therapy will facilitate cortical (brain) reorganization, and help the child overcome learned non-use, eventually leading to improved function of the weak arm or leg.

Phase 1: Initial evaluations will be completed on day 1 of the program. They include interview questions and direct assessment of the participant's ability to use the affected arm as well as to participate in meaningful age-appropriate activities. These assessments include the Motor Activity Log, The Pediatric Arm Function Test, the Inventory of New Motor Activities and Programs, the Pediatric Quality of Life Inventory, and the Preschool Activity Card Sort or Children's Assessment of Activity Preferences.

Phase 2: The participant completes an intensive occupational therapy program which consists of 15 three-hour therapy sessions (5 days per week for 3 weeks). Throughout the three week program the un-involved arm will be constrained with a removable cast. The cast is to be worn 24 hours per day throughout the 3 week program with the exception of regularly scheduled cast changes, washings and skin checks completed by the treating occupational therapist. During the direct intervention sessions, a focus of therapy is on facilitation of new motor skills for the affected arm. Play is utilized as a means to motivate the pediatric participants with activities and exercises specifically chosen to facilitate new motor skills. The program also includes a variety of tools and activities caregivers will complete increasing adherence to the program outside of the direct intervention sessions and to facilitate transfer of affected upper extremity use into the real world environment.

Phase 3: Immediately following the 3 week intervention program the participant's performance is re-assessed. Additionally weekly follow up evaluations are completed by phone for a period of one month. Three months following the intervention program the participant will return for follow up evaluations.

Constraint-Induced Movement Therapy in a Pediatric Oncology Population

Constraint Induced Movement Therapy in a Pediatric Oncology Population (SJCIT): A Pilot Study

To evaluate the feasibility of conducting a 3-week constraint-induced therapy program in patients with upper extremity hemiplegia as a result of a tumor. We will conclude that conducting this constraint induced therapy program is not feasible if more than 2 patients out of eight patients do not complete the program for any reason, with exception those outlined as excused reasons for absence from a therapy sessions (acute illness of the participant, illness of a parent, or other interruptions considered allowable/unavoidable by the study PI).

To describe the change in amount of extremity use at pre-intervention, post-intervention and at follow-up.

To describe the change in quality of extremity use at pre-intervention, post-intervention and at follow-up.

St. Jude Children's Research Hospital

Wounds and Injuries

Heart and Blood Diseases

Immune System Diseases

Infections

Diseases and Abnormalities at or Before Birth

Nutritional and Metabolic Diseases

Musculoskeletal Diseases

Skin and Connective Tissue Diseases

Rare Diseases

Cerebral Palsy

Parkinson Disease

Stroke

Spinal Cord Injuries

Sclerosis

Multiple Sclerosis

Ataxia

Cerebellar Ataxia

Myelitis

Myelitis, Transverse

Friedreich Ataxia

Muscle Weakness

Paresis

Brain Injuries

Brain Injuries, Traumatic

Parkinsonian Disorders

Ganglion Cysts

Synovial Cyst

Basal Ganglia Diseases

Movement Disorders

Synucleinopathies

Neurodegenerative Diseases

Autoimmune Diseases

Demyelinating Autoimmune Diseases, CNS

Autoimmune Diseases of the Nervous System

Demyelinating Diseases

Spinal Cord Diseases

Trauma, Nervous System

Brain Damage, Chronic

Spinocerebellar Ataxias

Spinocerebellar Degenerations

Cerebellar Diseases

Heredodegenerative Disorders, Nervous System

Genetic Diseases, Inborn

Mitochondrial Diseases

Metabolic Diseases

Communicable Diseases

Central Nervous System Infections

Neuroinflammatory Diseases

Syndrome

Paraneoplastic Syndromes

Paraneoplastic Syndromes, Nervous System

Craniocerebral Trauma

Chronic Graft Versus Host Disease

Transverse Myelitis

Spinocerebellar Ataxia

Participants will engage in a live zoom exercise session. Participants will undergo 45 minutes of aerobic exercise intervention, three times a week, for a period of 12 weeks. Exercise will include repetitive bouts of high intensity exercises with intermittent periods of rest or active recovery. circuit of moves like 'jabs', 'hooks' etc, and a strength and endurance class that promotes postural awareness.

Participants will undergo 45 minutes of aerobic exercise intervention, three times a week, for a period of 12 weeks, using a pre-recorded class that they can do according to their own schedule. Exercise will include repetitive bouts of high intensity exercises with intermittent periods of rest or active recovery. circuit of moves like 'jabs', 'hooks' etc, and a strength and endurance class that promotes postural awareness.

Exercise will include repetitive bouts of high intensity exercises with intermittent periods of rest or active recovery. circuit of moves like 'jabs', 'hooks' etc, and a strength and endurance class that promotes postural awareness.

Seated exercise

Kathleen Friel

To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).

This study aims to examine how effective seated Zoom exercise classes are for a person with CNI for addressing cardiovascular health, physical wellness and quality of life. If these classes prove to be effective, online platforms could be a viable avenue for those with CNI to exercise and increase/maintain wellness without having to leave their homes. The investigators are also attempting to determine if a class with a live instructor vs a pre-recorded class has an effect on motivation, compliance, exertion and modifications/safety.

The entire process, including screening and consenting, will be done via Zoom and Redcap, potentially providing a blueprint for the future studies. This process can enable participants to participate in studies with minimal inconvenience, expense and effort of traveling for the consent process.

One group will attend live zoom classes with instructor feedback, and the other group will exercise using pre-recorded sessions.

Home Based Tele-exercise for People With Chronic Neurological Impairments

We plan to use the concept, methods and analysis as a framework to develop evidence-based protocols for future cohorts and studies. We have made a commitment to publish all relevant scientific information in a timely manner. Unpublished information may be available to interested individuals or organizations by request to the Principal Investigator.

Heart rate on last day of training compared to heart rate on first day of training

a 36-item instrument used to measure an individual's perceived health status in physical, psychological, emotional, intellectual, spiritual, and social wellness constructs

a self-assessment measure of enjoyment with their current physical activity

measures physical health and mental health

standardized instrument for pain assessment in clinical and research practice. It is an 11-point scale from 0 (no pain) to 10 (the most intense pain) at rest and during movement

standardized measure to evaluate perceived intensity of exertion, effort, and fatigue during physical exercise

is a 24-item scale to assess the reason that motivates a person to exercise

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Constraint-Induced Movement Therapy in a Pediatric Oncology Population	NCT01447810	Hemiplegia Brain Tumor	Focused rigidit...	2 Years - 12 Years	St. Jude Children's Research Hospital
Home Based Tele-exercise for People With Chronic Neurological Impairments	NCT04564495	Neurologic Diso... Stroke Spinal Cord Inj... Cerebral Palsy Hemiplegia Hemiparesis Multiple Sclero... Parkinson Disea... Trauma, Brain Transverse Myel... Friedreich Atax...	Seated exercise	18 Years - 75 Years	Burke Medical Research Institute
Home Based Tele-exercise for People With Chronic Neurological Impairments	NCT04564495	Neurologic Diso... Stroke Spinal Cord Inj... Cerebral Palsy Hemiplegia Hemiparesis Multiple Sclero... Parkinson Disea... Trauma, Brain Transverse Myel... Friedreich Atax...	Seated exercise	18 Years - 75 Years	Burke Medical Research Institute

Spots Global Cancer Trial Database for hemiplegia

Every month we try and update this database with for hemiplegia cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for hemiplegia

Every month we try and update this database with for hemiplegia cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for hemiplegia cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.