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Gastrointestinal Diseases

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Pharmaceutical Solutions

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Cola

patients will do elective open colonic mass resection and anastomosis will receive Infusion of 6 ml/kg/hr. Ringer's solution.

patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

pulse pressure variation

Infusion of 6 ml/kg/hr. Ringer's solution.

conventional fluid management

pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.

All Patients will be assigned randomly by using computerized program to one of the two equal groups. Patients will be (forty five patients per group):

Group A ;( control group) Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 6 ml/kg/hr. Ringer's solution.

Group B; Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

Intraoperative fluid volume, hemodynamics, serum lactate and intestinal edema will be measured after induction of anesthesia and every hour till the end of the operation, length of the hospital stay, first time to gastrointestinal motion and postoperative complications are recorded.

participant eligibility is based on self-representation of gender identity

Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis

Ain Shams University

Assistant Professor of Anesthesia

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Behaviors and Mental Disorders

Prostatic Neoplasms

Erectile Dysfunction

Urinary Incontinence

Enuresis

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Sexual Dysfunction, Physiological

Sexual Dysfunctions, Psychological

Mental Disorders

Psychotic Disorders

Sham Magnetic stimulation for comparison.

Sham Magnetic stimulation

Mahadevan R. Rajasekaran, PhD

After recruitment, 20 male patients will be assigned 1:1 to either age-matched control (G1: sham) or age-matched intervention (G2: pelvic magnetic stimulation; TPMS) groups using computer-generated process, and baseline parameters will be established. All patients will be instructed by the investigators to perform standard of care pelvic floor exercise for the duration of the study. In addition, G2 patients will receive TPMS, while G1 patients will undergo sham treatment.

The investigators will use a custom TPMS device that targets pelvic muscles. The investigators will apply low amplitude (5%) TPMS to improve blood flow, then high amplitude (30-50%) to strengthen pelvic muscles. The treatment regimen will involve two 20-minute sessions/visit and 2 -visits per week for 12-weeks (final monitoring at 24 weeks). TPMS will be administered by a trained clinical coordinator under the supervision of a urologist. Symptom scores and hemodynamic changes will be evaluated monthly. MRI for assessing muscle thickness will be performed in the beginning (before TPMS) and at the end (after TPMS) of the study. The investigators will assess functional improvements using symptom scores. Morphological changes will be determined by MRI.

Intervention to prevent prostate cancer surgery related urological issues

Our proposal is aimed at preventing sexual dysfunction and urinary incontinence in prostate cancer survivors, a gender specific cancer.

Transpelvic Magnetic Stimulation to Improve Urogenital Function

Feasibility Testing of Transpelvic Magnetic Stimulation as a Novel Intervention toImprove Urogenital Function in Prostate Cancer Survivors

Primary outcome measure will be to determine improvements in male sexual (erectile) function after magnetic stimulation therapy.

The objective measure for erectile function will be the International Index of Erectile Function (IIEF), a validated, 5-item symptom-subjective score. These five items focus on male erectile function. Response options are based on rating scales from 1 to 5 and the responses are added to form a total IIEF-5 score from 5 to 25. Lower scores indicate poor sexual function and higher scores after therapy will indicate improvement.

The first objective measure for urinary incontinence (UI) change will be the number of pads used in 24-hours as an index of urine leakage. Higher number of pad use will indicate severe UI and lower number pad use after therapy will indicate improvement.

Penile blood flow will be measured as peak systolic velocity (mm/sec) using laser Doppler method.

Muscle thickness (mm) will be measured by anatomical MRI and quantified using imaging software such as Amira.

The second objective measure for urinary incontinence (UI) change will be the total weight of the pads used in 24-hours as an index of urine leakage. Higher number of pad weight will indicate severe UI and lower number pad use after therapy will indicate improvement.

The third objective measure for urinary incontinence (UI) change will be the change in urinary symptom scores. The investigators will use International Consultation of Incontinence Questionnaire (ICIQ)-symptom score (scores range: 0-21), a score which assesses the symptoms and effect of UI on quality of life. Higher scores will indicate severe UI and lower scores after therapy will indicate improvement.

VA Office of Research and Development

Infections

Communicable Diseases

Abdominal Neoplasms

Intraabdominal Infections

The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy.than collect the data of ScvO2 and Pcv-aCO2:

ScvO2≥70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and "\>6mmHg"

The patients with ScvO2 \<70% will receive the standardized fluid therapy for 6 hours.than collect the data of ScvO2 and Pcv-aCO2:

ScvO2\<70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and "\>6mmHg"

The patients with ScvO2 \<70% will receive the standardized fluid therapy for 6 hours.

standardized fluid therapy

The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy.

conventional fluid therapy

Yang Yang, physician

Yang Lu, physician

Wanhua Wang, director

This research will confirm that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new monitoring index to improve the therapeutic effect of these patients.

1. Confirmed that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new monitoring index to improve the therapeutic efficacy of this kind of patients.
2. Pcv-aCO2 effectively reflected the improvement of tissue and organ microcirculation disorder through the individual goal target treatment to guide the fluid resuscitation in the hemodynamic instability patients.
3. Research of the correlation between Pcv-aCO2 and the organ function in patients with abnormal hemodynamics after operation.

Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery

Clinical Study of Central Venous-to-Arterial Carbon Dioxide Difference(Pcv-aCO2) in the Evaluation of Fluid Therapy for Postoperative Patients With Abdominal Cancer

The change of Central venous oxygen saturation (ScvO2, %)after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of hemoglobin (Hb, g/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of blood lactic acid (Lac, mmol/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of Cardiac Index (CI, L/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of oxygen supply (DO2, ml/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of oxygen consumption (VO2, ml/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of Pcv-aCO2 (mmHg) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of treatment success rate(%) of patients in different groups.

Collect the index of 28 day mortality(%) of patients in different groups.

Collect the index of hospitalization course(days) of patients in different groups.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis	NCT05502835	Intraoperative ... Hemodynamics Serum Lactate Intestinal Edem... Length of the H... First Time to G... Postoperative C...	pulse pressure ... conventional fl...	18 Years - 70 Years	Ain Shams University
Transpelvic Magnetic Stimulation to Improve Urogenital Function	NCT04488068	Prostate Cancer Erectile Dysfun...	Sham Magnetic s...	50 Years - 80 Years	VA Office of Research and Development
Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery	NCT02977429	Abdominal Tumor Abdominal Infec...	standardized fl... conventional fl...	18 Years - 65 Years	Tianjin Medical University Cancer Institute and Hospital
Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery	NCT02977429	Abdominal Tumor Abdominal Infec...	standardized fl... conventional fl...	18 Years - 65 Years	Tianjin Medical University Cancer Institute and Hospital
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis	NCT05502835	Intraoperative ... Hemodynamics Serum Lactate Intestinal Edem... Length of the H... First Time to G... Postoperative C...	pulse pressure ... conventional fl...	18 Years - 70 Years	Ain Shams University
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis	NCT05502835	Intraoperative ... Hemodynamics Serum Lactate Intestinal Edem... Length of the H... First Time to G... Postoperative C...	pulse pressure ... conventional fl...	18 Years - 70 Years	Ain Shams University
Transpelvic Magnetic Stimulation to Improve Urogenital Function	NCT04488068	Prostate Cancer Erectile Dysfun...	Sham Magnetic s...	50 Years - 80 Years	VA Office of Research and Development

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