Symptoms and General Pathology

All Conditions

Skin and Connective Tissue Diseases

Musculoskeletal Diseases

Hypertrophy

Keloid

Cicatrix, Hypertrophic

Cicatrix

Fibrosis

Pathological Conditions, Anatomical

Rheumatic Diseases

Collagen Diseases

Connective Tissue Diseases

All Drugs and Chemicals

Anti-Infective Agents

Glucocorticoids

Fusidic Acid

Anti-Bacterial Agents

Enzyme Inhibitors

0.4 cm creme is applied and covered with a plaster (treatment under occlusion). Dosage every second or third day Treatment is started one week before removal of the central venous catheter and continued for four weeks

Betamethason-17-valerate and fusidic acid

Henrik Hasle, Professor

Most children with cancer need a central venous catheter. These catheters are typically placed on the anterior thorax, where the risk of hypertrophic scarring and keloid development is greatly enhanced. A significant part of the children who have survived childhood cancer are troubled by their scars.

Topical glucocorticoid treatment is known to induce a reduction of the collagen in the connective tissue.

The investigators hypothesize that treatment with topical glucocorticoids for one week before and three weeks after removal of a central venous catheter, will reduce the formation of hypertrophic scarring and keloid development in children.

Scars After Central Venous Catheters

Topical Treatment With Glucocorticoids to Prevent Hypertrophic Scars and Keloid Due to Central Venous Access in Children

Mette Møller Handrup

MD, PhD

Neoplasms

Blood and Lymph Conditions

Diseases and Abnormalities at or Before Birth

Immune System Diseases

Rare Diseases

Psoriasis

Eczema

Pain

Lichen Planus

Prurigo

Acne Vulgaris

Scleroderma, Localized

Neurodermatitis

Alopecia

Alopecia Areata

Cysts

Granuloma

Granuloma Annulare

Epidermal Cyst

Keratoacanthoma

Muir-Torre Syndrome

Skin Diseases

Skin Diseases, Papulosquamous

Hypotrichosis

Hair Diseases

Dermatitis

Skin Diseases, Eczematous

Lichenoid Eruptions

Exanthema

Lymphoproliferative Disorders

Lymphatic Diseases

Necrobiotic Disorders

Prurigo Nodularis

Lichen Planopilaris

Frontal Fibrosing Alopecia

Morphea

Localized Scleroderma

Anti-Arrhythmia Agents

Channel Blockers

Central Nervous System Depressants

Lidocaine

Anesthetics

Anesthetics, Local

Sodium Channel Blockers

Diuretics, Potassium Sparing

This arm will include an injection mixture of corticosteroid and lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with lidocaine

Corticosteroid with normal saline

Brian Drolet, MD

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment.

Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure.

The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.

Pain Outcomes Following Intralesional Corticosteroid Injections

The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial

IPD will not be shared with other researchers

Assessed using the visual analog scale (0-10 scale). Zero indicates no pain, 10 indicates worst pain ever.

Vanderbilt University Medical Center

Assistant Professor

This arm will include an injection mixture of corticosteroid and lidocaine

Corticosteroid with lidocaine: Intralesional corticosteroid injection

Corticosteroid With Lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with normal saline: Intralesional corticosteroid injection

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Scars After Central Venous Catheters	NCT01113125	Hypertrophic Sc... Keloids	Betamethason-17... Fusidic Acid	- 21 Years	Aarhus University Hospital
Scars After Central Venous Catheters	NCT01113125	Hypertrophic Sc... Keloids	Betamethason-17... Fusidic Acid	- 21 Years	Aarhus University Hospital
Scars After Central Venous Catheters	NCT01113125	Hypertrophic Sc... Keloids	Betamethason-17... Fusidic Acid	- 21 Years	Aarhus University Hospital
Pain Outcomes Following Intralesional Corticosteroid Injections	NCT03630198	Keloid Alopecia Areata Acne Hypertrophic Sc... Epidermal Inclu... Frontal Fibrosi... Lichen Plano-Pi... Keratoacanthoma Plaque Psoriasi... Lichen Simplex ... Prurigo Nodular... Nummular Eczema Granuloma Annul... Morphea Lichen Planus	Corticosteroid ... Corticosteroid ...	12 Years -	Vanderbilt University Medical Center

Spots Global Cancer Trial Database for keloid

Every month we try and update this database with for keloid cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for keloid

Every month we try and update this database with for keloid cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for keloid cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.