Symptoms and General Pathology

All Conditions

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Rare Diseases

Recurrence

Small Cell Lung Carcinoma

Carcinoma, Non-Small-Cell Lung

Neoplasm Metastasis

Lung Neoplasms

Lung Diseases

Papilloma

Mesothelioma

Mesothelioma, Malignant

Respiratory Tract Neoplasms

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Thoracic Neoplasms

Respiratory Tract Diseases

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Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Mesothelial

Pleural Neoplasms

Small Cell Lung Cancer

Malignant Mesothelioma

Recurrent Respiratory Papillomatosis

Anti-Infective Agents

All Drugs and Chemicals

Formaldehyde

Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.

bronchoscopic and lung imaging studies

diagnostic bronchoscopy

All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

histopathologic examination

optical coherence tomography

Rana Hejal, MD

RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.

PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

OBJECTIVES:

* Correlate optical coherence tomography images of the airway with airway histology.
* Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Fresh Bronchi from 10 subjects undergoing pneumonectomy or lobectomy for malignant and benign processes will be obtained from the UHCMC Pathology Department as discarded tissue from fresh specimens

Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

Optical Coherence Tomography of Human Airways

National Cancer Institute (NCI)

Case Comprehensive Cancer Center

Infections

Ear, Nose, and Throat Diseases

Virus Diseases

Laryngeal Diseases

Neoplasms, Squamous Cell

Vaccines

Immunomodulating Agents

autologous tumor cell vaccine

James M. Oleske, MD

RATIONALE: Vaccines made from papilloma virus cells may make the body build an immune response to and kill papilloma cells.

PURPOSE: Phase II trial to study the effectiveness of papilloma virus vaccine in treating young patients with recurrent papilloma of the larynx.

OBJECTIVES: I. Determine the immune response in patients with juvenile papilloma of the larynx treated with autogenous vaccine derived from each patient's own tumor.

OUTLINE: Patients receive autogenous papilloma vaccine intradermally and subcutaneously weekly for 20 weeks.

PROJECTED ACCRUAL: Not specified

Papilloma Virus Vaccine Therapy in Treating Young Patients With Recurrent Papilloma of the Larynx

Phase II Study of Immunotherapy With Autogenous Papilloma Vaccine in Patients With Recurrent Juvenile Papilloma of the Larynx

University of Medicine and Dentistry of New Jersey

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease	NCT00733252	Lung Cancer Malignant Mesot... Metastatic Canc... Nonmalignant Ne... Precancerous Co...	bronchoscopic a... diagnostic bron... histopathologic... optical coheren...	-	Case Comprehensive Cancer Center
Papilloma Virus Vaccine Therapy in Treating Young Patients With Recurrent Papilloma of the Larynx	NCT00002454	Precancerous Co...	autologous tumo...	1 Year -	National Cancer Institute (NCI)
Papilloma Virus Vaccine Therapy in Treating Young Patients With Recurrent Papilloma of the Larynx	NCT00002454	Precancerous Co...	autologous tumo...	1 Year -	National Cancer Institute (NCI)

Spots Global Cancer Trial Database for lung papilloma