Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Substance Related Disorders

Behaviors and Mental Disorders

Rare Diseases

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Tobacco Use Disorder

Small Cell Lung Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Substance-Related Disorders

Chemically-Induced Disorders

Mental Disorders

Psychotic Disorders

Small Cell Lung Cancer

laboratory biomarker analysis

screening questionnaire administration

bronchoscopic and lung imaging studies

computed tomography

endoscopic biopsy

quality-of-life assessment

Stephen Lam, MD

RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to treat.

PURPOSE: This clinical trial is studying screening methods to see how well they find lung cancer early in current or former smokers.

OBJECTIVES:

* To develop a new multi-modal screening strategy and integrated methods to detect lung cancer early in current and former smokers.
* To evaluate the impact of the screening modalities on the quality of life of these participants.
* To develop a decision analytic framework for determining the cost and effectiveness of a novel lung cancer screening strategy in Canada.

OUTLINE: This is a multicenter study.

Participants undergo spirometry at baseline. Participants also undergo spiral CT scan at baseline and then at 1 and 2 years. Participants with semi-solid or solid nodules of 5-10 mm or ground glass opacity (GGO) 8-10 mm or those with growth of an existing nodule, development of a solid component in GGO, or a new nodule undergo an additional CT scan at 3 months. Some participants also undergo autofluorescence and white light bronchoscopy and bronchial biopsies.

Blood samples are collected at baseline and then annually for 2 years for biomarker studies. Participants diagnosed with lung cancer undergo additional blood sample collection for biomarker studies.

Participants complete questionnaires on sociodemographic factors, smoking, occupational exposure, family history, medical data, quality of life, and anxiety at baseline and then every 6 months for up to 2 years.

Screening Methods in Finding Lung Cancer Early in Current or Former Smokers

Early Detection of Lung Cancer - A Pan Canadian Study

British Columbia Cancer Agency

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Head and Neck Neoplasms

Nasopharyngeal Carcinoma

Mouth Neoplasms

Oral Cancer

Laryngeal Cancer

Hypopharyngeal Cancer

Lip and Oral Cavity Cancer

cytology specimen collection procedure

immunohistochemistry staining method

sputum cytology

bronchoscopy

comparison of screening methods

J. Michael Hamilton, MD

RATIONALE: Fluorescent bronchoscopy, when used in combination with conventional white light bronchoscopy, may improve the ability to detect early lung cancer.

PURPOSE: A pilot study to evaluate fluorescent light bronchoscopy plus conventional bronchoscopy as a tool for screening and detecting lung cancer in persons with completely resected head and neck cancer or successfully treated early-stage lung cancer.

OBJECTIVES:

* Evaluate the efficacy of autofluorescence bronchoscopy using the Lung Imaging Fluorescence Endoscopic System with conventional white-light bronchoscopy for the early detection of lung cancer in selected patients with known or suspected bronchogenic carcinoma, completely resected head and neck cancer, and successfully treated early-stage lung cancer.
* Determine the number of areas of moderate dysplasia, severe dysplasia, and carcinoma in situ in patients treated with surgery for lung cancer compared with patients treated with combined modality therapy.
* Determine the ability of immunohistochemistry to predict whether lesions of moderate to severe dysplasia will progress to cancer.

OUTLINE: If possible, patients produce a 3-day pooled sputum sample prior to bronchoscopy. Patients then undergo tracheobronchial white-light bronchoscopy followed by autofluorescence bronchoscopy using the Lung Imaging Fluorescence Endoscopic (LIFE) Device attached to a computerized video camera. Visualized tissue is classified as either normal, abnormal, or suspicious. Abnormal or suspicious tissue is biopsied, as is tissue from 1 or 2 randomly chosen normal sites. Immunohistochemical analysis of the biopsy material is conducted without knowledge of the bronchoscopic results. Patients unable to produce a sputum sample prior to bronchoscopy are required to do so after bronchoscopy.

PROJECTED ACCRUAL: A total of 70 patients will be entered.

Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer

PILOT STUDY OF THE CORRELATION BETWEEN THE FINDINGS OF ATYPICAL/MALIGNANT CELLS IN SPUTUM AND FLUORESCENCE BRONCHOSCOPY IN PATIENTS AT RISK FOR LUNG CANCER OF THE LIFE IMAGING SYSTEM AND WHITE LIGHT BRONCHOSCOPY

National Cancer Institute (NCI)

Symptoms and General Pathology

Recurrence

Neoplasm Metastasis

Papilloma

Mesothelioma

Mesothelioma, Malignant

Precancerous Conditions

Carcinoid Tumor

Adenoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Mesothelial

Pleural Neoplasms

Malignant Mesothelioma

Recurrent Respiratory Papillomatosis

Anti-Infective Agents

All Drugs and Chemicals

Formaldehyde

Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.

diagnostic bronchoscopy

All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

histopathologic examination

optical coherence tomography

Rana Hejal, MD

RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.

PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

OBJECTIVES:

* Correlate optical coherence tomography images of the airway with airway histology.
* Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Fresh Bronchi from 10 subjects undergoing pneumonectomy or lobectomy for malignant and benign processes will be obtained from the UHCMC Pathology Department as discarded tissue from fresh specimens

Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

Optical Coherence Tomography of Human Airways

Case Comprehensive Cancer Center

Dimercaprol

Chelating Agents

bronchoalveolar lavage

study of high risk factors

Abraham Chachoua, MD

RATIONALE: Imaging procedures such as computed tomography may improve the ability to detect lung cancer earlier.

PURPOSE: Screening and diagnostic study of computed tomography in women who are at risk for lung cancer.

OBJECTIVES:

* Determine the ability of computed tomography (CT) to detect early lung parenchymal abnormalities in women at high risk for lung cancer.
* Determine the number of abnormal findings detected by CT that develop into lung cancer in these patients.
* Correlate these abnormalities with the presence of K-ras and p53 mutations in the sputum and bronchoalveolar lavage in these patients.
* Develop and implement appropriate educational materials regarding lung cancer in women and provide referrals to other programs, such as smoking cessation programs.

OUTLINE: Patients complete a questionnaire at baseline to assess demographics, medical history, smoking history, menopausal status, estrogen therapy, and diet.

Patients then undergo a low-dose computed tomography (CT) scan without contrast. Patients with normal CT results undergo additional CT scans every 12 months.

Patients with abnormal CT results undergo a diagnostic CT scan (in the absence of prior studies). Patients with indeterminate nodules (less than 5 mm in size) undergo surveillance CT studies within 3-4 months. If nodules remain unchanged in size, patients undergo additional surveillance CT studies at 6 months and 1 year. Patients with lung parenchymal abnormalities on CT suspicious for malignancy undergo a bronchoscopy with biopsy and bronchoalveolar lavage (BAL). Patients with abnormal CT scan(s) and negative BAL for p53 and/or K-ras mutations or normal histology and positive BAL for K-ras and/or p53 mutations undergo additional CT scans at 6 months and 1 year. Patients with biopsy-proven malignancy after bronchoscopy are referred for definitive treatment.

PROJECTED ACCRUAL: A total of 500 patients will be accrued for this study.

Computed Tomography for Early Detection of Cancer in Women Who Are at Risk for Lung Cancer

Prevention and Early Detection of Lung Cancer in Women

NYU Langone Health

radiography

John K. Gohagan, PhD, FACE

RATIONALE: New imaging procedures such as spiral CT may improve the ability to detect lung cancer in patients who are at high risk for the disease.

PURPOSE: Randomized clinical trial to compare the effectiveness of a spiral CT scan with that of a chest x-ray in detecting lung cancer in patients who are at high risk for the disease.

OBJECTIVES: I. Compare the efficacy of screening spiral CT scan and screening chest x-ray in detecting lung cancer in current or former smokers at high risk for lung cancer.

OUTLINE: This is a randomized, multicenter study of lung cancer screening. Patients are randomized to one of two screening arms. Arm I: Patients undergo one spiral CT scan. Arm II: Patients undergo one chest x-ray. Patients and their primary care physicians are notified of test results within 3 weeks of the exam.

PROJECTED ACCRUAL: A total of 3,000 participants (1,500 per screening arm) will be accrued for this study at six screening centers (500 per center) by October 31, 2000.

Lung Screening Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Screening Methods in Finding Lung Cancer Early in Current or Former Smokers	NCT00751660	Lung Cancer Tobacco Use Dis...	laboratory biom... screening quest... bronchoscopic a... computed tomogr... endoscopic biop... quality-of-life...	50 Years - 75 Years	British Columbia Cancer Agency
Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer	NCT00019201	Head and Neck C... Lung Cancer	cytology specim... immunohistochem... sputum cytology bronchoscopic a... bronchoscopy comparison of s... endoscopic biop...	18 Years -	National Cancer Institute (NCI)
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease	NCT00733252	Lung Cancer Malignant Mesot... Metastatic Canc... Nonmalignant Ne... Precancerous Co...	bronchoscopic a... diagnostic bron... histopathologic... optical coheren...	-	Case Comprehensive Cancer Center
Computed Tomography for Early Detection of Cancer in Women Who Are at Risk for Lung Cancer	NCT00012103	Lung Cancer	bronchoalveolar... screening quest... sputum cytology bronchoscopic a... bronchoscopy computed tomogr... study of high r...	18 Years -	NYU Langone Health
Lung Screening Study	NCT00006382	Lung Cancer	bronchoscopic a... comparison of s... computed tomogr... radiography study of high r...	55 Years - 74 Years	National Cancer Institute (NCI)
Computed Tomography for Early Detection of Cancer in Women Who Are at Risk for Lung Cancer	NCT00012103	Lung Cancer	bronchoalveolar... screening quest... sputum cytology bronchoscopic a... bronchoscopy computed tomogr... study of high r...	18 Years -	NYU Langone Health
Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer	NCT00019201	Head and Neck C... Lung Cancer	cytology specim... immunohistochem... sputum cytology bronchoscopic a... bronchoscopy comparison of s... endoscopic biop...	18 Years -	National Cancer Institute (NCI)
Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer	NCT00019201	Head and Neck C... Lung Cancer	cytology specim... immunohistochem... sputum cytology bronchoscopic a... bronchoscopy comparison of s... endoscopic biop...	18 Years -	National Cancer Institute (NCI)

Spots Global Cancer Trial Database for bronchoscopic and lung imaging studies