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Polycystic Ovary Syndrome

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Female Urogenital Diseases and Pregnancy Complications

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46, XX Disorders of Sex Development

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Thioctic Acid

Inositol

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Alpha-lipoic Acid

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Therapy with alpha-lipoic acid (800 mg), myoinositol (2000 mg) and folic acid (400 mcg) daily for six months

myo-inositol,alpha-lipoic acid and folic acid

The aim of our study is to investigate the effects of a combined treatment of alpha-lipoic acid and myoinositol on clinical, endocrine and metabolic features of women affected by PCOS. The study Group included 40 patients treated with a combined therapy of alpha-lipoic acid (800 mg), myoinositol (2000 mg) and folic acid (400 mcg) daily for six months. The investigation includes menstrual pattern, hirsutism score, hormonal assays, oral glucose tolerance test, lipidic profile at baseline and after six months of treatment.

Combined Therapy With Myo-inositol and Alpha-Lipoic Acid in PCOS Women

Effects of Combined Therapy With Myo-inositol and Alpha-Lipoic Acid on Clinical, Endocrine and Metabolic Features in Women Affected by Polycystic Ovary Syndrome

Testosterone, Androstenedione, free androgen index

Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride

Catholic University of the Sacred Heart

Professor

Obesity

Hypoglycemic Agents

Metformin

Insulin

Insulin, Globin Zinc

metformin 1500 mg

myoinositol 1500 mg

The aim of this study is to compare the effects of six months treatment of two insulin-lowering therapies on the clinical and endocrine-metabolic parameters in obese women affected by polycystic ovary syndrome. The study group includes 40 patients, randomly allocated to subgroup A (metformin 1500 mg/day) and subgroup B (myo-inositol 1500 mg/day). The investigations include menstrual pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipid profile at baseline and after six months of treatment.

Myo-inositol Versus Metformin in Obese Women With Polycystic Ovary Syndrome

Myo-inositol Versus Metformin: Effects of Six Months Treatment on Clinical, Endocrine and Metabolic Features in Obese Women With Polycystic Ovary Syndrome

Area under the curve insulin post oral glucose tolerance test (μUI/ML/180min), M value of euglycemic hyperinsulinaemic clamp(mg/kg/min).

principal investigator

Behaviors and Mental Disorders

Metabolic Syndrome

Insulin Resistance

Quality of Life

Androgens

Electroacupuncture

Physical exercise

Untreated control

Elisabet Stener-Victorin, Prof, PhD

Hypothesis:

The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high sympathetic nerve activity, hyperandrogenism hyperinsulinaemia, insulin resistance with progression to type II diabetes and cardiovascular disease (CVD) as well as psychological distress and reduced quality of life. Physical exercise and electro-acupuncture decrease high concentrations of androgens, induce regulare menstrual pattern, inhibits high sympathetic activity and restore the PCOS induced disturbances.

Primary outcome: Changes in androgen concentrations and menstrual pattern

Secondary outcome: changes in sympathetic nerve activity, uterus peristalsis, ovarian morphology, adipose tissue related variables, insulin sensitivity, coagulation factors and health related quality of life and symptoms of anxiety and depression.

Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture

Polycystic Ovary Syndrome (PCOS) - The Female Metabolic Syndrome Genes And Processes In The Aetiology And Pathogenesis Of PCOS And Identification Of New Treatment Strategies

Göteborg University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Combined Therapy With Myo-inositol and Alpha-Lipoic Acid in PCOS Women	NCT02651636	Polycystic Ovar... Menstrual Patte... Hyperandrogenis... Metabolic Featu...	myo-inositol,al...	18 Years - 35 Years	Catholic University of the Sacred Heart
Myo-inositol Versus Metformin in Obese Women With Polycystic Ovary Syndrome	NCT01791647	Polycystic Ovar...	metformin 1500 ... myoinositol 150...	18 Years - 35 Years	Catholic University of the Sacred Heart
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture	NCT00484705	Polycystic Ovar...	Electroacupunct... Physical exerci... Untreated contr...	18 Years - 37 Years	Göteborg University
Combined Therapy With Myo-inositol and Alpha-Lipoic Acid in PCOS Women	NCT02651636	Polycystic Ovar... Menstrual Patte... Hyperandrogenis... Metabolic Featu...	myo-inositol,al...	18 Years - 35 Years	Catholic University of the Sacred Heart

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