Symptoms and General Pathology

All Conditions

Neoplasms

Mouth and Tooth Diseases

Rare Diseases

Facies

Parotid Neoplasms

Salivary Gland Neoplasms

Mouth Neoplasms

Head and Neck Neoplasms

Mouth Diseases

Stomatognathic Diseases

Parotid Diseases

Salivary Gland Diseases

Oral Cancer

Pharmaceutical Solutions

All Drugs and Chemicals

Methylene Blue

Enzyme Inhibitors

Mb group will undergo surgeries with methylene blue staining

Control group will undergo surgeries without methylene blue staining

For MB group, the staining of the glandular tissue will be obtained with 3-4 mL of 1% MB that will be introduced into the gland via the salivary duct several minutes before the surgery.The trans-oral catheterization of the Stensen's duct will be performed and the solution will be injected via intravenous cannula.The glandular tissue will turn dark blue.

Methylene blue dye

Ismail Ali Mohamed

usefulness of the methylene blue staining for identification of facial nerve in parotid gland surgery

The specific surgical morbidity remains significant in parotid gland surgery. In addition to temporary facial weakness and permanent facial nerve injury, postparotidectomy depression and Frey's syndrome (gustatory sweating) are specific for this type of surgery. To reduce the surgical morbidity, several modifications of parotidectomy have been implemented but postsurgical complications remain especially facial nerve injury . To overcome this difficulty, an identification method might be used such as preoperative intravital staining of the gland with methylene blue (MB).

Although MB staining is not designed to be used as a sole technique, it can be combined with other techniques such as identification of the anatomic landmarks. MB staining is simple, inexpensive, and not time consuming technique.It is an indirect facial nerve identification technique, because there is no nerve handling,thus decreasing iatrogenic nerve impairment.After injection of the parotid gland with MB dye, fine white nerve fibers can be observed . Tumors in the parotid gland are also easily seen because they are not stained and will be visible in the surgical field.

Role of Methylene Blue in Parotid Surgery

Role of Methylene Blue Dye in Identification of Facial Nerve in Parotid Surgery

Twenty cases presented to outpatient clinic in Assiut university hospital with benign or primary malignant parotid gland tumors will be included in the study, clinically evaluated, confirmation of diagnosis will be achieved by CT, MRI, or CT/MRI investigations , ultrasonography and fine-needle aspiration biopsy (FNAB).

then Divide the selected cases into two groups randomly; group A for surgeries with MB staining and group B for surgeries without MB staining that serves as control group. type of surgery will be chosen according to CT or MRI data and fine-needle aspiration biopsy (FNAB)then Follow up facial nerve injury manifestations for the included cases for one year for comparison between 2 groups

Assiut University

Resident doctor

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

Methylene blue (1%)

Rhenium sulfure

Surgical procedure

Anatomo-pathologic procedure

Jean-Pierre Bellocq, MD

The aim of this study is to evaluate the performance of a double labelling method using isotope and methylene blue dye injection to localize precisely Sentinel Lymph Node (SLN) in a series of 100 patients with infiltrative breast cancer justifying SLN excision. Method and patients: SLN excision will be performed on 100 patients treated for infiltrative breast cancer. After preoperative methylene blue dye injection and lymphoscintigraphy, individual localization of the radioactive and stained nodes will be performed. After the surgery, SLN will be submitted to serial analysis and immunohistochemistry. A comparison of the two methods and an economical evaluation of the complete procedure will be performed.

Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope

Identification of Sentinel Lymph Node (SLN) in Breast Cancer Care: Clinical and Economical Evaluation of a Double Method Using Isotope and Methylene Blue Dye Injection.

University Hospital, Strasbourg, France

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Role of Methylene Blue in Parotid Surgery	NCT05401370	Parotid Tumor	Methylene blue ...	18 Years - 80 Years	Assiut University
Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope	NCT00314405	Infiltrative Br...	Methylene blue ... Rhenium sulfure Surgical proced... Anatomo-patholo...	18 Years -	University Hospital, Strasbourg, France
Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope	NCT00314405	Infiltrative Br...	Methylene blue ... Rhenium sulfure Surgical proced... Anatomo-patholo...	18 Years -	University Hospital, Strasbourg, France

Spots Global Cancer Trial Database for methylene blue dye