Neoplasms

Mouth and Tooth Diseases

All Conditions

Rare Diseases

Parotid Neoplasms

Salivary Gland Neoplasms

Mouth Neoplasms

Head and Neck Neoplasms

Mouth Diseases

Stomatognathic Diseases

Parotid Diseases

Salivary Gland Diseases

Oral Cancer

All patients included will benefit from the two methods of evaluating the anatomical relationships between the facial nerve and the parotid tumor:

1. New medical imaging technique evaluated: high-resolution 3 Tesla parotid MRI with specific sequences and gadolinium injection;
2. Gold standard: Intraoperative examination.

Amelie YAVCHITZ

Adrien COLLIN

a YAVCHITZ

adrien Collin

jean-Baptiste Lecanu

Elisabeth SAUVAGET

Stéphane HANS

1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added. Evaluation of the exact position of the parotid tumor relative to the trunk of the facial nerve and its first branches, classification into two categories: on contact (≤ 5 mm) or at a distance (\> 5 mm).
2. nd visit: Surgical intervention of the parotid tumor. The surgeon will specify the same data as that collected by the radiologists after the MRI.
3. rd visit: Post-operative consultation in the week following the intervention. The surgeon will look for the occurrence of post-operative facial paralysis.

FArial NErf MRI in the Preoperative Assessment of PArotide Tumors

measurements by the radiologist on the high resolution 3Tesla MRI with specific sequences.

assessment by the surgeon during the excision surgery of the parotid lesion

Fondation Ophtalmologique Adolphe de Rothschild

Symptoms and General Pathology

Infections

Nervous System Diseases

Postoperative Complications

Bell Palsy

Facial Paralysis

Facies

Paralysis

Bell's Palsy

Pei-Jen Lou, MD, Ph.D

The aim of this study was to determine the histopathological results of parotid tumors and postoperative complications after partial superficial or total parotidectomy with facial nerve dissection and superficial musculoaponeurotic system reconstruction.

Retrospective Clinical Outcome of Parotid Tumor Surgery

Record the grade of facial palsy in patients receiving the surgery of parotid tumor

National Taiwan University Hospital

Pharmaceutical Solutions

All Drugs and Chemicals

Methylene Blue

Enzyme Inhibitors

Mb group will undergo surgeries with methylene blue staining

Control group will undergo surgeries without methylene blue staining

For MB group, the staining of the glandular tissue will be obtained with 3-4 mL of 1% MB that will be introduced into the gland via the salivary duct several minutes before the surgery.The trans-oral catheterization of the Stensen's duct will be performed and the solution will be injected via intravenous cannula.The glandular tissue will turn dark blue.

Methylene blue dye

Ismail Ali Mohamed

usefulness of the methylene blue staining for identification of facial nerve in parotid gland surgery

The specific surgical morbidity remains significant in parotid gland surgery. In addition to temporary facial weakness and permanent facial nerve injury, postparotidectomy depression and Frey's syndrome (gustatory sweating) are specific for this type of surgery. To reduce the surgical morbidity, several modifications of parotidectomy have been implemented but postsurgical complications remain especially facial nerve injury . To overcome this difficulty, an identification method might be used such as preoperative intravital staining of the gland with methylene blue (MB).

Although MB staining is not designed to be used as a sole technique, it can be combined with other techniques such as identification of the anatomic landmarks. MB staining is simple, inexpensive, and not time consuming technique.It is an indirect facial nerve identification technique, because there is no nerve handling,thus decreasing iatrogenic nerve impairment.After injection of the parotid gland with MB dye, fine white nerve fibers can be observed . Tumors in the parotid gland are also easily seen because they are not stained and will be visible in the surgical field.

Role of Methylene Blue in Parotid Surgery

Role of Methylene Blue Dye in Identification of Facial Nerve in Parotid Surgery

Twenty cases presented to outpatient clinic in Assiut university hospital with benign or primary malignant parotid gland tumors will be included in the study, clinically evaluated, confirmation of diagnosis will be achieved by CT, MRI, or CT/MRI investigations , ultrasonography and fine-needle aspiration biopsy (FNAB).

then Divide the selected cases into two groups randomly; group A for surgeries with MB staining and group B for surgeries without MB staining that serves as control group. type of surgery will be chosen according to CT or MRI data and fine-needle aspiration biopsy (FNAB)then Follow up facial nerve injury manifestations for the included cases for one year for comparison between 2 groups

Assiut University

Resident doctor

Behaviors and Mental Disorders

Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Depression

Syndrome

Congenital Abnormalities

Sweating, Gustatory

Autonomic Nervous System Diseases

Primary Dysautonomias

Hyperhidrosis

Sweat Gland Diseases

Skin Diseases

Frey's Syndrome

29 patients (ADM group) had a total parotidectomy with a simultaneous ADM implantation

41 patients (control group) had a total parotidectomy alone

Wen Luo, DMD

The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy.

Seventy patients who underwent total parotidectomy were selected for inclusion in the study. We analyzed 41 cases of total parotidectomy (control group) and 29 cases of simultaneous ADM implantation following total parotidectomy (ADM group) for infraauricular depressed deformities and the presence of gustatory flushing or sweating. The follow-up periods ranged from 6 months to 7 years.

The Results showed facial contours and bilateral symmetry improved after surgery in the ADM group. In the control group, an infraauricular depressed deformity was evident in all 41 cases. Frey's syndrome was recorded in one patient (3.4%) from the ADM group and 14 patients (34.1%) from the control group. No cases of immune rejection, infection, hematoma, or salivary fistula were observed in either group.

The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome

The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy

to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy

West China Hospital

West China Hospital of Stomatology

What value is given to MRI diffusion and perfusion sequences in the diagnosis of parotid tumors? Is a fine needle aspiration associated with MRI systematically necessary? The aim of the research is to study the performance of diffusion and perfusion MRI sequences in the diagnosis of parotid tumors on a large series of cases.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors	NCT04613349	Parotid Tumor	MRI	18 Years -	Fondation Ophtalmologique Adolphe de Rothschild
Retrospective Clinical Outcome of Parotid Tumor Surgery	NCT01983176	Parotid Tumors Postoperative C...		10 Years - 84 Years	National Taiwan University Hospital
Role of Methylene Blue in Parotid Surgery	NCT05401370	Parotid Tumor	Methylene blue ...	18 Years - 80 Years	Assiut University
The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome	NCT01414790	Parotid Tumor	ADM	10 Years - 79 Years	West China Hospital
MRI and Fine Needle Aspiration in the Diagnosis of Parotid Tumors	NCT05152056	Parotid Tumor		6 Years -	University Hospital, Strasbourg, France
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors	NCT04613349	Parotid Tumor	MRI	18 Years -	Fondation Ophtalmologique Adolphe de Rothschild

Spots Global Cancer Trial Database for parotid tumor