Neoplasms

Symptoms and General Pathology

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Nervous System Diseases

Neoplasm Metastasis

Disease Progression

Brain Neoplasms

Neoplastic Processes

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Inclusion visit, 1 month later, 6 month later

MRI perfusion sequence

Natalia SHOR, MD

Nadya pyatigorskaya, MD

Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment.

The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment

The metastasis progression versus radionecrosis following GK treatment can sometimes be difficult to distinguish. 60 patients will be included in this prospective, monocentric study. 3 MRI (baseline, 1month and 6 month follow-ups) will be performed. Two neuroradiologists will blindly analyse the MRIs comparing ASL sensibility and specificity to the standard morphological evaluation and T2 perfusion.

ASL in Brain Metastasis MRI Following Gamma Knife Treatment

ASL in Diagnostics of Tumor Progression Versus Radionecrosis in Brain Metastasis Following Gamma Knife Treatment.

Quantitative analysis (rCBF) of the evolution of brain metastasis between the initiation of treatment and 6 months after.

Assistance Publique - Hôpitaux de Paris

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
ASL in Brain Metastasis MRI Following Gamma Knife Treatment	NCT04833335	Brain Metastase...	MRI perfusion s...	18 Years -	Assistance Publique - Hôpitaux de Paris
ASL in Brain Metastasis MRI Following Gamma Knife Treatment	NCT04833335	Brain Metastase...	MRI perfusion s...	18 Years -	Assistance Publique - Hôpitaux de Paris
ASL in Brain Metastasis MRI Following Gamma Knife Treatment	NCT04833335	Brain Metastase...	MRI perfusion s...	18 Years -	Assistance Publique - Hôpitaux de Paris

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