Spots Global Cancer Trial Database for ASL in Brain Metastasis MRI Following Gamma Knife Treatment

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Trial Identification

Brief Title: ASL in Brain Metastasis MRI Following Gamma Knife Treatment

Official Title: ASL in Diagnostics of Tumor Progression Versus Radionecrosis in Brain Metastasis Following Gamma Knife Treatment.

Study ID: NCT04833335

Conditions

Brain Metastases

Interventions

MRI perfusion sequence

Study Description

Brief Summary: Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment. The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment

Detailed Description: The metastasis progression versus radionecrosis following GK treatment can sometimes be difficult to distinguish. 60 patients will be included in this prospective, monocentric study. 3 MRI (baseline, 1month and 6 month follow-ups) will be performed. Two neuroradiologists will blindly analyse the MRIs comparing ASL sensibility and specificity to the standard morphological evaluation and T2 perfusion.