Spots Global Cancer Trial Database for neoadjuvant immunotherapy

Every month we try and update this database with for neoadjuvant immunotherapy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Real-world Clinical Outcomes of NSCLC Patients Receiving Neoadjuvant Immunotherapy	NCT06317558	NSCLC	Neoadjuvant imm... Other drugs for...	18 Years - 85 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC	NCT05800340	Non-Small Cell ... RET Driver Muta... BRAF V600 Mutat... Erb-B2 Receptor... MET Amplificati... MET Exon 14 Ski...	Toripalimab Nab paclitaxel Pemetrexed Carboplatin	18 Years -	Guangdong Provincial People's Hospital
The Effect of Toripalimab Plus Radiotherapy in Patients With Operable Stage II-IIIA (N+) Non Small Cell Lung Cancer	NCT05798845	NSCLC	SBRT+LDRT Toripalimab Chemotherapy dr... Toripalimab	18 Years - 75 Years	Shanghai Chest Hospital
Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC	NCT05800340	Non-Small Cell ... RET Driver Muta... BRAF V600 Mutat... Erb-B2 Receptor... MET Amplificati... MET Exon 14 Ski...	Toripalimab Nab paclitaxel Pemetrexed Carboplatin	18 Years -	Guangdong Provincial People's Hospital
Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC	NCT05645380	Triple Negative... Breast Cancer	Carboplatin Docetaxel Doxorubicin Cyclophosphamid... Pembrolizumab	18 Years - 70 Years	University of Kansas Medical Center
Perioperative Tislelizumab Plus Chemotherapy for Resectable Thoracic Oesophageal Squamous Cell Carcinoma	NCT06056336	Esophageal Squa... Neoadjuvant Che... Adjuvant Therap...	Tislelizumab	18 Years - 75 Years	Shanghai Chest Hospital
Neoadjuvant Immunotherapy in EGFR-mutant Localized NSCLC	NCT05244213	Non-small Cell ... EGFR Activating...	Sintilimab Carboplatin Nab paclitaxel	18 Years - 75 Years	Guangdong Provincial People's Hospital
The Real World Study of Neoadjuvant Immunotherapy in Early Stage NSCLC in China	NCT04286841	Immunotherapy Lung Cancer	Immunotherapy	18 Years -	Guangdong Association of Clinical Trials
Study of Neoadjuvant Nivolumab or Placebo Plus Chemotherapy Followed by Surgery and Adjuvant Treatment in Subjects With Resectable ESCC	NCT05213312	Esophageal Squa...	Nivolumab Cisplatin Paclitaxel 5Fluorouracil Esophagectomy (...	18 Years - 75 Years	Shanghai Zhongshan Hospital
Perioperative Tislelizumab Plus Chemotherapy for Resectable Thoracic Oesophageal Squamous Cell Carcinoma	NCT06056336	Esophageal Squa... Neoadjuvant Che... Adjuvant Therap...	Tislelizumab	18 Years - 75 Years	Shanghai Chest Hospital
Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC	NCT05800340	Non-Small Cell ... RET Driver Muta... BRAF V600 Mutat... Erb-B2 Receptor... MET Amplificati... MET Exon 14 Ski...	Toripalimab Nab paclitaxel Pemetrexed Carboplatin	18 Years -	Guangdong Provincial People's Hospital
Efficacy and Safety of Tislelizumab in Combination With Disitamab-vedotin as Neoadjuvant Therapy for HER2-positive High-risk Upper Tract Urothelial Carcinoma (UTUC)	NCT05837806	Neoadjuvant Imm...	tislelizumab+di...	18 Years -	Tianjin Medical University Second Hospital
A Single-arm Exploratory Study of Neoadjuvant Therapy	NCT05527808	Lung Adenocarci...	Tislelizumab pemetrexed cis-platemum or carboplatin	18 Years - 75 Years	Guangzhou Institute of Respiratory Disease
Effect of Neoadjuvant Anti-PD-1 Immunotherapy on Perioperative Analgesia and Postoperative Delirium	NCT05273827	Immunotherapy Analgesia NSCLC Delirium	neoadjuvant imm... Neoadjuvant che...	18 Years -	Tianjin Medical University Cancer Institute and Hospital
Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy	NCT06099951	Colorectal Canc...	Serplulimab + F... Radiation thera...	18 Years - 75 Years	Sun Yat-sen University
Phase II Study on Neoadjuvant Therapy of AK104 Combined With Nab-paclitaxel/Carboplatin in Fertility Preserving Surgery	NCT06209294	Neoadjuvant Imm... Cervical Cancer Fertility-spari...	AK104 Carboplatin Nab paclitaxel	18 Years - 45 Years	Fudan University
Pembrolizumab in Locally Advanced Sinonasal Carcinoma	NCT05925491	Sinonasal Undif...	Pembrolizumab	18 Years -	Istituti Clinici Scientifici Maugeri SpA
Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC	NCT05645380	Triple Negative... Breast Cancer	Carboplatin Docetaxel Doxorubicin Cyclophosphamid... Pembrolizumab	18 Years - 70 Years	University of Kansas Medical Center
Pulmonary Resectable Osteosarcoma Treated by Metastasectomy and Pre-operative Immunotherapy and Stereotactic Body Radiotherapy (PROMIS): a Prospective Clinical Trial	NCT06114225	Osteosarcoma	metastasectomy ...	10 Years - 65 Years	Ruijin Hospital
Neoadjuvant Immunotherapy in EGFR-mutant Localized NSCLC	NCT05244213	Non-small Cell ... EGFR Activating...	Sintilimab Carboplatin Nab paclitaxel	18 Years - 75 Years	Guangdong Provincial People's Hospital
CT and MRI in Prediction of Response in Patients With Gastric Cancer Following Neoadjuvant Chemotherapy and/or Immunotherapy	NCT04913896	Gastric Cancer Magnetic Resona... Tomography, X-R... Neoadjuvant Imm... Neoadjuvant Che...	PD-1 inhibitor	18 Years - 80 Years	The First Hospital of Jilin University
A Single-arm Exploratory Study of Neoadjuvant Therapy	NCT05527808	Lung Adenocarci...	Tislelizumab pemetrexed cis-platemum or carboplatin	18 Years - 75 Years	Guangzhou Institute of Respiratory Disease
Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma	NCT06426797	Locally Advance...	Cadonilimab plu...	18 Years -	Peking University People's Hospital
Phase II Study on Neoadjuvant Therapy of AK104 Combined With Nab-paclitaxel/Carboplatin in Fertility Preserving Surgery	NCT06209294	Neoadjuvant Imm... Cervical Cancer Fertility-spari...	AK104 Carboplatin Nab paclitaxel	18 Years - 45 Years	Fudan University

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