Neoplasms

Symptoms and General Pathology

All Conditions

Digestive System Diseases

Neoplasm Metastasis

Colorectal Neoplasms

Colonic Diseases

Gastrointestinal Diseases

Gastrointestinal Neoplasms

Intestinal Neoplasms

Intestinal Diseases

Neoplasms, Second Primary

Digestive System Neoplasms

Rectal Diseases

Neoplastic Processes

Herbal and Botanical

All Drugs and Chemicals

Cola

Surgical resection of the primary tumour followed by chemotherapy +/- targeted therapy regime.

Surgical resection of the colon tumour, R0. No surgical intervention on metastasis.

surgery of the primary tumour

Chemotherapy with or without biological drugs.

chemotherapy

Iuliia Alimova, MD

Currently, the question remains whether palliative primary tumor resection could improve overall survival of minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases. The aim of this study is to determine if there is an improvement in overall survival of palliative primary tumor resection followed by chemotherapy in minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases compared to those of upfront chemotherapy/radiotherapy alone.

The present study is a single-center retrospective observational cohort study with a propensity score matching. Between 2016 and 2022 from our institutional database minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases will be selected. Patients will be divided into two groups:

1. Surgical resection of the primary tumour before to systemic therapy
2. Systemic therapy without previous resection of the primary tumour. Propensity score matching (PSM) will be performed, to minimize the selection bias by adjusting variables that may affect the survival of patients. Categorical variables will be compared using the chi-square test or Fisher's exact test. Continuous variables will be compared using the Student's t-test or Mann-Whitney U test. Survival rate will be determined by using Kaplan-Meier analysis with a log-rank test. Univariate and multivariate analyses for survival will be conducted using Cox proportional hazard models. Statistical results will be considered significant at p values less than 0.05.

Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases

Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases Versus Chemotherapy Alone

PFS is defined as the time interval between the date of diagnosis and the first date of progression of the metastatic disease or death in both treatment arms.

State Scientific Centre of Coloproctology, Russian Federation

No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study

No intervention in this retrospective study

Daniel R Zwahlen, MD, MBA

Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.

Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

Estimation of Second Cancer Risk in Patients Planned With Different Radiotherapy Regimes for Rectal Cancer - A Planning Study and Model-based Analysis

LAR is calculated for variable Ages at exposure

Klinik Hirslanden, Zurich

Kantonsspital Graubuenden

MD, MBA

Behaviors and Mental Disorders

Recurrence

Head and Neck Neoplasms

Disease Attributes

Quality of Life

Radiotherapy

Kenneth Jensen, MD

Palliative radiotherapy for head and neck cancer is widely used but the effect and side effects are largely unknown. We will study the effect of short hypofractionated palliative radiotherapy (20 Gy in 4 fractions) on symptom intensity and -frequency as weel as side effects

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases	NCT05322486	Colorectal Neop... Intestinal Neop... Gastrointestina... Digestive Syste... Neoplasms by Si... Neoplasms Neoplasms, Seco... Neoplasm Metast... Digestive Syste... Gastrointestina... Colonic Disease Intestinal Dise... Rectal Diseases	surgery of the ... chemotherapy	18 Years -	State Scientific Centre of Coloproctology, Russian Federation
Secondary Cancer Risk After Radiation Therapy for Rectal Cancer	NCT02572362	Neoplasms, Seco...	No intervention...	18 Years - 100 Years	Kantonsspital Graubuenden
Secondary Cancer Risk After Radiation Therapy for Rectal Cancer	NCT02572362	Neoplasms, Seco...	No intervention...	18 Years - 100 Years	Kantonsspital Graubuenden
Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases	NCT05322486	Colorectal Neop... Intestinal Neop... Gastrointestina... Digestive Syste... Neoplasms by Si... Neoplasms Neoplasms, Seco... Neoplasm Metast... Digestive Syste... Gastrointestina... Colonic Disease Intestinal Dise... Rectal Diseases	surgery of the ... chemotherapy	18 Years -	State Scientific Centre of Coloproctology, Russian Federation
DAHANCA 20 Palliative Radiotherapy for Head and Neck Cancer	NCT00400426	Head and Neck N... Recurrence Neoplasms, Seco...	Radiotherapy	18 Years -	University of Aarhus

Spots Global Cancer Trial Database for neoplasms, second primary