Neoplasms

Digestive System Diseases

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Nervous System Diseases

Symptoms and General Pathology

Behaviors and Mental Disorders

Wounds and Injuries

Rare Diseases

Rectal Neoplasms

Prostatic Neoplasms

Stomach Neoplasms

Colonic Neoplasms

Delirium

Urinary Bladder Neoplasms

Liver Neoplasms

Fractures, Bone

Sigmoid Neoplasms

Kidney Neoplasms

Emergence Delirium

Confusion

Neurobehavioral Manifestations

Neurologic Manifestations

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Postoperative Complications

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Liver Diseases

Colorectal Neoplasms

Intestinal Neoplasms

Intestinal Diseases

Rectal Diseases

Urologic Neoplasms

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Colonic Diseases

Kidney Diseases

Sigmoid Diseases

Stomach Cancer

Adjuvants, Anesthesia

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Antiemetics

Psychotropic Drugs

Gastrointestinal Agents

Fentanyl

Droperidol

Droperidol 1.25 mg and fentanyl 0.025 mg (diluted with normal saline up to 5ml) is to be administrated intravenously 30 minutes before the end of the procedure.

The same volume of normal saline is to be administrated intravenously 30 minutes before the end of the procedure.

low-dose neuroleptanalgesia

Placebo

Diansan Su, Doctor

Zhenling Huang, Doctor

Xiao Zhang, MS

Cuixia Song, BS

Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources. In order to evaluate whether an intraoperative administration of low-dose neuroleptanalgesia reduces postoperative delirium, droperidol 1.25 mg and fentanyl 0.025 mg or normal saline is used by intravenous injection 30 minutes before the end of the operation, in elderly patients with non-cardiac major surgery under general anesthesia. The efficiency and safety of neuroleptanalgesia on the incidence of POD would be evaluated in elderly patients.

Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients

Low-dose Neuroleptanalgesia Reduce the Occurrences of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Major Surgery : a Randomized Controlled Trial

This outcome will be measured using a numeric rating scale from 1 ( dissatisfaction ) to 3 (very satisfied)

Shanghai 8th People's Hospital

RenJi Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients	NCT05068180	Stomach Neoplas... Colonic Neoplas... Rectal Neoplasm... Sigmoid Neoplas... Liver Neoplasms Kidney Neoplasm... Urinary Bladder... Prostatic Neopl... Osteoarthropath... Fractures, Bone Gynecologic Can...	low-dose neurol... Placebo	65 Years - 85 Years	RenJi Hospital
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients	NCT05068180	Stomach Neoplas... Colonic Neoplas... Rectal Neoplasm... Sigmoid Neoplas... Liver Neoplasms Kidney Neoplasm... Urinary Bladder... Prostatic Neopl... Osteoarthropath... Fractures, Bone Gynecologic Can...	low-dose neurol... Placebo	65 Years - 85 Years	RenJi Hospital

Spots Global Cancer Trial Database for noncardiac major surgery