Neoplasms

All Conditions

Digestive System Diseases

Carcinoma

Carcinoma, Hepatocellular

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Antineoplastic Agents

All Drugs and Chemicals

Sorafenib

Patient with advanced stage HCC receiving sorafenib

It was calculated by dividing the neutrophil count by the lymphocyte count.

The neutrophil-to- lymphocyte ratio

It was calculated using the following formula: serum albumin (g/L) + 0.005 × total lymphocyte count/μL

Prognostic nutrition index

Mona Abdelrahmam, MD

Amr Zagloul, MD

Ahmed othman, MD

Rafat Abd El Aal, MD

Evaluating the nutrition status of patients with advanced HCC who received sorafenib.

Using the pretreatment nutrition status and quality of life as predictors to sorafenib response

This a cross sectional study will be conducted on 100 HCC treated with sorafenib Data were gathered from medical records, including

age sex body weight and height (BMI) pre-therapy laboratory counts of white cells, neutrophils, lymphocytes, monocyte, hemoglobin and platelets; bilirubin, albumin and globulin concentration, AST, ALT, AFP, PT and CONC

Barcelona Clinic Liver Cancer Stage (BCLC) of all patients

The neutrophil-to- lymphocyte ratio (NLR) was calculated by dividing the neutrophil count by the lymphocyte count.

The platelet- to-lymphocyte ratio (PLR) was calculated by dividing the platelet count by the lymphocyte count.

Weight loss difference after treatment Portal hypertension was defined as presence of either collaterals on radiological examination, esophageal varices by upper gastrointestinal endoscopy and/or thrombocytopenia.

Quality of life assessment. QoL was assessed using FACT Hepatobiliary Symptom Index (FHSI-8) Questionnaire. QoL was assessed at base line and 3-6 months after start of treatment.

Predictors of Sorafenib Response in HCC

Predictors of Sorafenib Response in Patients With Advanced Hepatocellular Carcinoma

Sohag University

Principal investigator

Colorectal Neoplasms

Intestinal Neoplasms

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Herbal and Botanical

Common Bean

Randomized participants consume 1 meal and 1 snack per day that does not include either rice bran or navy bean powder for 28 days.

Randomized participants consume 1 meal and 1 snack per day containing cooked navy bean powder (35 g/day) for 28 days.

Randomized participants consume 1 meal and 1 snack per day containing rice bran (30 g/day) for 28 days.

Placebo-Control Meals and Snacks

Cooked Navy Bean Powder Meals and Snacks

Rice Bran Meals and Snacks

Elizabeth P Ryan, PhD

The purpose of this study is to explore the effects of cooked navy bean powder or rice bran consumption on the stool microbiome and metabolome of colorectal cancer survivors and healthy adults.

Objectives:

1. To learn about how increased cooked navy bean powders or rice bran dietary intake affect the stool microbiota of colorectal cancer survivors and healthy adults.
2. To determine whether cooked navy bean powders or rice bran consumption modulate microbial metabolism.
3. To observe dietary changes in the blood, urine and stool metabolite profiles and inflammatory cytokines.

Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial

BENEFIT: Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial

National Cancer Institute (NCI)

Poudre Valley Health System

Colorado State University

Assistant Professor of Toxicology and Nutrition

Symptoms and General Pathology

Respiratory Tract (Lung and Bronchial) Diseases

Nutritional and Metabolic Diseases

Behaviors and Mental Disorders

Rare Diseases

Recurrence

Lung Neoplasms

Malnutrition

Carcinoma, Non-Small-Cell Lung

Small Cell Lung Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Quality of Life

Small Cell Lung Cancer

The oncology care team will provide participants with nutrition toolkit involving printed educational materials, a nutrition prescription, referral to registered dietitians (RDs) for remotely-delivered medical nutrition therapy counseling, and home-delivery of medically tailored meals.

The oncology care team will provide participants with a nutrition toolkit involving printed educational materials.

Medical oncology providers will refer participants to oncology RDs for remotely delivered medical nutrition therapy counseling. For cohort 1, participants will receive nutrition counseling for 8 months. The counseling will be provided on a weekly basis during the first 6 months and every other week during the last 2 months (for cohort 1 only). For cohort 2, participants will receive nutrition counseling for 6 months. The ultimate frequency of nutrition counseling being provided to each participant will also be adjusted according to the participant's preference and needs.

Nutritional Counseling

Medically tailored meals will be provided to participants in the intervention group for a total of 24 weeks for both cohorts. During the first 8 weeks of the intervention, 3 meals/day will be provided each week for a total of 168 meals per participant. It will be followed by less frequent meal provision during the subsequent 16 weeks following this schedule: 3 meals/day will be provided every other week for the next 8 weeks (a total of 84 meals per participant); and 3 meals/day will be provided every four weeks during the last 8 weeks (a total of 42 meals per participant). The number of meals provided to each participant may be adjusted according to participant's preference and needs.

Medically Tailored Meals (MTMs)

Oncology providers will advise participants with lung cancer to follow evidence-based nutrition recommendations using a Nutrition Prescription. The Nutrition Prescription aims to enhance providers' role in communicating basic nutrition advice to participants with lung cancer. It contains seven recommendations, adapted from the newly released Cancer Prevention Recommendations by WCRF/AICR with strong evidence-base.

Nutrition Prescription

Oncology care providers will assess the nutritional status of patients with lung cancer using PG-SGA Short Form (the Scored Patient-Generated Subjective Global Assessment). PG-SGA is an interdisciplinary patient assessment in oncology and other chronic catabolic conditions. The short form contains four patient generated historical components (weight history, food intake symptoms, and activities and function).

Nutrition Assessment

Patients will receive a printed copy of a Nutrition Toolkit from providers. Evidence-based nutrition recommendations have been compiled for cancer survivors from 4 sources into a Nutrition Toolkit. The sources include: (1) AmericanCancer Society (ACS) Nutrition and Physical Activity Guidelines for Cancer Survivors; (2)World Cancer Research Fund / American Institute for Cancer Research (WFRF/AICR) Cancer Nutrition Guide; (3) National Cancer Institute (NCI) Eating Hints; and (4) National Comprehensive Cancer Network (NCCN) Guidelines for Cancer Survivors. The Nutrition Toolkit outlines topics about the impact of cancer treatment on dietary intake patterns and quality, strategies to manage treatment-related eating issues, maintaining a healthy weight post treatment, and evidence-based recommendations and practical. Nutrition Toolkit strategies for improving diet quality and maintaining an optimal weight for cancer survivors.

Nutrition Toolkit

Monthly emails will be sent to participants to encourage the use of the toolkit with healthy recipes and general nutrition information.

Monthly Emails

FangFang Zhang, MD, PhD

Colleen Spees, PhD, MEd, RD, LD, FAND

The NutriCare study aims to develop, implement, and evaluate the efficacy of an innovative intervention strategy (medically tailored meals plus nutrition counseling) to integrate nutrition into the standard of care for oncology to improve outcomes of vulnerable patients with lung cancer. The NutriCare study evaluates the efficacy of the intervention on optimizing nutritional status, reducing treatment-related toxicities, and improving the quality of life of patients with lung cancer who are economically disadvantaged, uninsured, racial and ethnic minorities, elderly, and/or rural residents from four major medical centers in diverse regions of the United States (U.S.). There will be two cohorts for NutriCare with cohort 1 recruiting 150 patients completing an 8-month intervention and cohort 2 recruiting 120 patients completing a 6-month intervention.

For the proposed study, we will randomize participants into two groups at a 1:1 ratio to an intervention or an enhanced control group. For participants randomized to the enhanced control group, the NutriTool, the oncology care team will provide participants with a nutrition toolkit involving printed educational materials. For participants randomized to the intervention group, the NutriCare, the oncology care team will additionally provide participants with home-delivery of medically tailored meals and referral to registered dietitians (RDs) for remotely-delivered nutrition counseling.

NutriCare Plus a Medically Tailored Meal Intervention Among Patients With Lung Cancer

NutriCare Intervention on Optimizing Nutritional Status, Reducing Treatment-Related Toxicities, and Improving Quality of Life Among Vulnerable Patients With Lung Cancer

(a) participation; (b) retention; (c) compliance

Change in diet quality and intake of key food groups and nutrients as assessed by the National Cancer Institute Diet History Questionnaire (DHQ III)

Change in weight and percent weight loss as measured in the clinic

Change in food insecurity measured by the U.S. Department of Agriculture (USDA) Household Food Security Survey

Change in patient-reported symptoms (fatigue, pain, nausea, vomiting, appetite loss, and sleep disturbance) as assessed by a Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE)

Change in patient-reported functional outcomes (physical, social, and cognitive functioning) assessed by GAD-7

Change in patient-reported functional outcomes (physical, social, and cognitive functioning) assessed by PHQ-9

Change in quality of life as assessed by EORTC-QLQ-30

Change in quality of life as assessed by EORTC-QLQ-LC13

Rate of hospitalizations will assessed by medical record review and linkage with discharge data

Rate of ED visits assessed by medical record review and linkage with discharge data

Rate of treatment-related toxicities assessed by the treating medical oncologist using the National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events (CTCAE)

Treatment completion (dose reductions and treatment delays) assessed by the treating medical oncologist

Change in gut microbiome via metagenomic whole shotgun sequencing (mWGS)

National Death Index search performed approximately 5 years after the final patient is enrolled.

Fox Chase Cancer Center

M.D. Anderson Cancer Center

Ohio State University

Tufts Medical Center

Tufts University

Associate Professor, The Neely Family Professor and Associate Professor

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Nasopharyngeal Carcinoma

Nasopharyngeal Neoplasms

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Head and Neck Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Otorhinolaryngologic Diseases

Nutrison was added to regular diet while the patients can be fed through mouth. Nutrison will replace regular diet by NG or PEG while the patients can not eat for serious oral mucositis.

Regular diet without other nutritional intervention.

Nutrison(400-600ml/d) will be given to Arm 1 patient between regular diet. When the daily ration was cut down to 50%,100ml/h Nutrison was added. When grade Ⅲ-Ⅳ oral mucositis appeared, total Nutrison was applied to patients by NG or PEG.

Nutrison

The chemo-radiotherapy for the local advanced nasopharyngeal carcinoma patients will induce the mucosal ulcer and damage salivary glands. Consequently, it can disturb the nutrition conditions and clinical outcomes of patients. This research tries to evaluate the nutrition status at the baseline, before and after radiotherapy, during the follow-up by the body mass index, hematological indexes, immunological indexes, and nutrition questionnaires including PG-SGA and NRS 2002. Through the evaluation of two different nutritional interventions, the investigators aim to find an optimized assessment model and the best nutrition support patterns.

All nasopharyngeal patients received radical treatment including neo-adjuvant chemotherapy and concurrent chemo-radiotherapy. At the beginning, the investigators assign patient to experimental and control groups randomly. Patients in experimental group received standard nutritional support by adding NUTRISON. Control patients will give conventional nutritional guidance. The investigators collected all the nutritional indexed at first visit, before and after radiotherapy, 1, 3, 6, 9, 12 months after radiotherapy. All these data will be set into statistical software to produce an optimized model for clinical practice.

A Research About Nutrition Impact for Local Advanced Nasopharyngeal Carcinoma Patients

A Prospective, Randomized Controlled Open Research About the Impact of Nutritional Support on the Radiation Tolerance and Clinical Outcomes for Local Advanced Nasopharyngeal Carcinoma Patients

From the first treatment to the death of any causes

From the first treatment to the progress of diseases

Zhejiang Cancer Hospital

Nutrition Disorders

Diagnosing the nutritional status of cancer patients is extremely important. An appropriate nutritional status supports a better tolerance to the treatment. A working protocol is essential to start with Nutritional Screening. If it is detected Malnutrition Risk or Malnutrition, diet counseling, and the specific therapeutic for each patient must be provided.

This descriptive study will serve three aims:

* Register in the cancer patient's electronic medical record their nutritional status at the admission and when the patient is discharged.
* Determine the percentage of malnourished patients or in the risk of malnutrition who are admitted to hospitalization.
* Recognize the number of patients that required specialized nutritional care.

The purpose of this study is to determine if 30% of the patients admitted to the headquarters of SOLCA in Guayaquil from the Ecuadorian Cancer Society are at malnutrition risk or with any specific malnutrition level.

A prospective, descriptive, non-interventional study that will be performed from July 1st to October 4th of 2019 in all hospitalized patients of the Internal Medicine Service from SOLCA in Guayaquil from the Ecuadorian Cancer Society.

Statistical analysis: Central tendency measures. The results will be presented with tables and graphs.

Two weeks before the start of the study, the training of the personnel that will intervene in the screening of the participants will be carried out and will have a flow chart of actions to follow according to the status of patients.

NRS 2002: Nutritional Screen in Cancer Patients

Registration in the cancer patients' Clinical Record their nutritional status when they are admitted and when they are discharged

To know the percentage of malnourished patients or at risk of malnourishment that are admitted for hospitalization

Recognize the number of patients who needed specialized nutritional care

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Predictors of Sorafenib Response in HCC	NCT05967429	Hepatocellular ...	The neutrophil-... Prognostic nutr...	-	Sohag University
Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial	NCT01929122	Colorectal Canc...	Placebo-Control... Cooked Navy Bea... Rice Bran Meals...	18 Years -	Colorado State University
Predictors of Sorafenib Response in HCC	NCT05967429	Hepatocellular ...	The neutrophil-... Prognostic nutr...	-	Sohag University
NutriCare Plus a Medically Tailored Meal Intervention Among Patients With Lung Cancer	NCT04986670	Lung Cancer, Sm... Lung Cancer Met... Lung Cancer Rec... Treatment Side ... Lung Cancer, No... Nutritional Imb...	Nutritional Cou... Medically Tailo... Nutrition Presc... Nutrition Asses... Nutrition Toolk... Monthly Emails	18 Years - 100 Years	Tufts University
Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial	NCT01929122	Colorectal Canc...	Placebo-Control... Cooked Navy Bea... Rice Bran Meals...	18 Years -	Colorado State University
A Research About Nutrition Impact for Local Advanced Nasopharyngeal Carcinoma Patients	NCT02948699	Malignant Neopl...	Nutrison	18 Years - 65 Years	Zhejiang Cancer Hospital
A Research About Nutrition Impact for Local Advanced Nasopharyngeal Carcinoma Patients	NCT02948699	Malignant Neopl...	Nutrison	18 Years - 65 Years	Zhejiang Cancer Hospital
NRS 2002: Nutritional Screen in Cancer Patients	NCT04137666	Malnutrition (D... Nutrition Disor... Nutrition Surve... Scoring System Cancer Nutrition Relat...		18 Years -	Sociedad de Lucha Contra el Cáncer del Ecuador

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