Neoplasms

All Conditions

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Nasopharyngeal Carcinoma

Squamous Cell Carcinoma of Head and Neck

Nasopharyngeal Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Head and Neck Neoplasms

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Otorhinolaryngologic Diseases

Chronic Graft Versus Host Disease

Antineoplastic Agents

All Drugs and Chemicals

Docetaxel

Fluorouracil

Cisplatin

Induction chrono-chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy;Delivery time is different from the control group

control group:Induction routine-chemotherapy followed by cisplatin routine-chemotherapy concurrent combined with intensity-modulated radiation therapy

Chrono-chemotherapy+concurrent radiochemotherapy

Chrono-chemotherapy

Routine intravenous drip

Experimental group:docetaxel,cisplatin,5-FU

induction Chrono-chemotherapy

induction Routine-chemotherapy

Experimental group: cisplatin chrono-chemotherapy

cisplatin chrono-chemotherapy

control group:cisplatin routine-chemotherapy

cisplatin routine-chemotherapy

control group is similar to Experimental group

intensity-modulated radiation therapy

Feng Jin, Bachelor

Juan Li, Bachelor

Weili Wu, master

Jinhua Long, master

Yuanyuan Li, master

Xiuyun Gong, Bachelor

Xiaoxiao Chen, Bachelor

This study is to observe and compare the effect of docetaxel plus lobaplatin induction chemotherapy combined with lopoplatin chemoradiotherapy and TPF induction chemotherapy combined with cisplatin chemoradiotherapy on dendritic cells subsets in the treatment of locally advanced head and neck squamous cell carcinoma.

TPF program is currently the local advanced head and neck squamous cell carcinoma commonly used inducing chemotherapy, cisplatin is the preferred drug for the same period chemotherapy.Dendritic cells (DC) play an essential role in the induction and regulation of immune responses.The effect of radiation and chemotherapy is closely related to the patients' immune function.In this study, Phase II clinical trials were performed. Patients with locally advanced head and neck squamous cell carcinoma were randomly divided into experimental group and control group. The trial group was treated with docetaxel + lorosine-induced chemotherapy combined with lorplatin concurrent radiotherapy and chemotherapy. The control group was treated with TPF Cisplatin concurrent chemotherapy, observed the relationship between dendritic cells subsets and clinical prognosis of patients, to provide a new method for the treatment of locally advanced nasopharyngeal carcinoma and technical support

the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer

Phase II Clinical Randomized Study of the Effect of Chronomodulated Chemotherapy Followed by Concurrent IMRT Chemo-radiotherapy on the Dendritic Cells Subsets and Immunity in the Treatment of Advanced Nasopharyngeal Cancer

Evaluate the Progression-free survival at five years after Concurrent chemo-radiotherapy by RECIST.

Evaluate the Overall survival at five years after Concurrent chemo-radiotherapy by RECIST

By flow cytometry detection of two groups of peripheral blood dendritic cells subsets and lymphocyte subpopulation changes before and after the radiation and chemotherapy

Evaluate the immediate effect at 1year after Concurrent chemo-radiotherapy by RECIST

To assess and record nausea, vomiting, oral mucositis, diarrhea and other adverse drug reactions by CTC 4.0

Guiyang Medical University

Head and neck cancer director, chief researcher, clinical professor

Induction chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy

Induction chemotherapy followed by cisplatin routine-chemotherapy concurrent combined with intensity-modulated radiation therapy

Chrono-chemotherapy pump:Melodie

induction chemotherapy

Feng Jin, Professor

Comparing induction chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy (chrono-chemotherapy group) with induction chemotherapy followed by cisplatin routine-chemotherapy concurrent combined with intensity-modulated radiation therapy (routine-chemotherapy group) in the treatment of locally advanced nasopharyngeal carcinoma, observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.

Induction Chemotherapy Followed By Chrono-chemotherapy Concurrent With IMRT Of Locally Advanced NPC Clinical Study

Induction Chemotherapy Followed By Chrono-chemotherapy Concurrent With Intensity-modulated Radiotherapy In The Treatment Of Locally Advanced Nasopharyngeal Carcinoma PhaseⅡClinical Randomized Study

Feng Jing

Guiyang Medical College

Digestive System Diseases

Esophageal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Esophageal Cancer

Induction chrono-chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy

Induction routine-chemotherapy followed by cisplatin routine-chemotherapy concurrent combined with intensity-modulated radiation therapy

Hang Jiang, Bachelor degree

Ling Guo, Doctor

Ling Wu, Bachelor

Zhuoling Li, master

Hang Jiang, Bachelor

1. Observe and compare the chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy term efficacy of the treatment of locally advanced nasopharyngeal carcinoma.
2. Evaluation chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma safety and tolerability.

3）observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.

Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

Multi-center Phase II Clinical Randomized Study of Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

Evaluate the immediate effect at 1year after Concurrent chemo-radiotherapy by RECIST.

To assess and record nausea, vomiting, oral mucositis, diarrhea and other adverse drug reactions by CTC 3.0.

Evaluate the Overall survival at five years after Concurrent chemo-radiotherapy by RECIST.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer	NCT03196869	Locally Advance...	Chrono-chemothe... Routine intrave... induction Chron... induction Routi... cisplatin chron... cisplatin routi... intensity-modul...	18 Years - 70 Years	Guiyang Medical University
the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer	NCT03196869	Locally Advance...	Chrono-chemothe... Routine intrave... induction Chron... induction Routi... cisplatin chron... cisplatin routi... intensity-modul...	18 Years - 70 Years	Guiyang Medical University
Induction Chemotherapy Followed By Chrono-chemotherapy Concurrent With IMRT Of Locally Advanced NPC Clinical Study	NCT02187315	Nasopharyngeal ...	Chrono-chemothe... Routine intrave... induction chemo... cisplatin chron... intensity-modul... cisplatin routi...	18 Years - 70 Years	Guiyang Medical University
Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer	NCT02937519	Esophageal Neop...	Chrono-chemothe... Routine intrave... induction Chron... induction Routi... cisplatin chron... cisplatin routi... intensity-modul...	18 Years - 70 Years	Guiyang Medical University

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