Spots Global Cancer Trial Database for locally advanced head and neck squamous cell carcinoma
Every month we try and update this database with for locally advanced head and neck squamous cell carcinoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT05724602 | Locally Advance... | Xevinapant Placebo | 70 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| NBTXR3 With or Without Cetuximab in LA-HNSCC | NCT04892173 | Locally Advance... Aged | NBTXR3 Cetuximab Radiation Thera... | 65 Years - | Nanobiotix | |
| Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT05861557 | Locally Advance... | Toripalimab Stereotactic Bo... | 18 Years - | Tianjin Medical University General Hospital | |
| Study of Cemiplimab - TP Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck | NCT05376553 | Locally Advance... | Cemiplimab Cisplatin Docetaxel | 18 Years - | Icahn School of Medicine at Mount Sinai | |
| Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer | NCT05172245 | Clinical Stage ... Head and Neck C... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Maxillary Sinus... Stage III Hypop... Stage III Laryn... Stage III Lip a... Stage III Oroph... Stage III Sinon... Stage IVA Hypop... Stage IVA Laryn... Stage IVA Lip a... Stage IVA Oroph... Stage IVA Sinon... Stage IVB Hypop... Stage IVB Laryn... Stage IVB Lip a... Stage IVB Oroph... Stage IVB Sinon... | Biopsy Biospecimen Col... Cisplatin Computed Tomogr... Ipatasertib Magnetic Resona... Positron Emissi... Radiation Thera... | 18 Years - | National Cancer Institute (NCI) | |
| A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy | NCT06129864 | Locally Advance... | volrustomig | 18 Years - 130 Years | AstraZeneca | |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer | NCT04870840 | Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Malignant Poste... Stage II Cutane... Stage II Hypoph... Stage II Laryng... Stage II Nasoph... Stage II Oropha... Stage III Cutan... Stage III Hypop... Stage III Laryn... Stage III Nasop... Stage III Oroph... Unresectable He... Unresectable Or... | Proton Beam Rad... Quality-of-Life... Questionnaire A... | 18 Years - | M.D. Anderson Cancer Center | |
| Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC | NCT03426657 | Locally Advance... | Durvalumab + Tr... | 18 Years - 100 Years | University of Erlangen-Nürnberg Medical School | |
| ERBITUX® Followed by Adjuvant Treatment With Chemoradiation and ERBITUX® for Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT01218048 | Squamous Cell C... | Cetuximab Surgery Post-surgical r... Cisplatin or ca... | 18 Years - | University of Pittsburgh | |
| Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition | NCT04454489 | Advanced Head a... Recurrent Head ... Metastatic Head... Stage III Cutan... Locally Advance... Stage IV Cutane... | Pembrolizumab (... Quad-shot palli... | 18 Years - | Wake Forest University Health Sciences | |
| Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck | NCT05527782 | Locally Advance... | modified TPF Quality of life... | 18 Years - | Hospital Universitario Doctor Peset | |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer | NCT04870840 | Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Malignant Poste... Stage II Cutane... Stage II Hypoph... Stage II Laryng... Stage II Nasoph... Stage II Oropha... Stage III Cutan... Stage III Hypop... Stage III Laryn... Stage III Nasop... Stage III Oroph... Unresectable He... Unresectable Or... | Proton Beam Rad... Quality-of-Life... Questionnaire A... | 18 Years - | M.D. Anderson Cancer Center | |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer | NCT04870840 | Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Malignant Poste... Stage II Cutane... Stage II Hypoph... Stage II Laryng... Stage II Nasoph... Stage II Oropha... Stage III Cutan... Stage III Hypop... Stage III Laryn... Stage III Nasop... Stage III Oroph... Unresectable He... Unresectable Or... | Proton Beam Rad... Quality-of-Life... Questionnaire A... | 18 Years - | M.D. Anderson Cancer Center | |
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHN | NCT03117257 | Locally Advance... | Lobaplatin Cisplatin | 18 Years - 70 Years | Guiyang Medical University | |
| A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood | NCT06240689 | Locally Advance... | Sintilimab Placebo | 18 Years - 75 Years | Second Affiliated Hospital, School of Medicine, Zhejiang University | |
| the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer | NCT03196869 | Locally Advance... | Chrono-chemothe... Routine intrave... induction Chron... induction Routi... cisplatin chron... cisplatin routi... intensity-modul... | 18 Years - 70 Years | Guiyang Medical University | |
| the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer | NCT03196869 | Locally Advance... | Chrono-chemothe... Routine intrave... induction Chron... induction Routi... cisplatin chron... cisplatin routi... intensity-modul... | 18 Years - 70 Years | Guiyang Medical University | |
| Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer | NCT05245682 | Head and Neck C... Locally Advance... Locally Advance... Locally Advance... Locally Advance... Locally Advance... | Tolinapant Radiation Thera... | 18 Years - | Emory University | |
| Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHN | NCT03117257 | Locally Advance... | Lobaplatin Cisplatin | 18 Years - 70 Years | Guiyang Medical University | |
| Efficacy Study of Genexol-PM and Cisplatin in Locally Advanced Head and Neck Cancer | NCT01689194 | Locally Advance... | genexolPM + cis... | 18 Years - 75 Years | Seoul National University Hospital | |
| A Real-world Study of the Efficacy and Safety of Nimotuzumab in Combination With Chemoradiotherapy for LASCCHN | NCT04949503 | Locally Advance... | nimotuzumab | 18 Years - | Biotech Pharmaceutical Co., Ltd. | |
| Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN | NCT05743270 | Squamous Cell C... Locally Advance... Recurrent Head ... | RP3 CCRT(concurrent... carboplatin and... nivolumab | 18 Years - | Replimune Inc. | |
| TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | NCT05872880 | Oral Squamous C... Locally Advance... | Modified radica... Radical surgery | 18 Years - 65 Years | Xiangya Hospital of Central South University | |
| ERBITUX® Followed by Adjuvant Treatment With Chemoradiation and ERBITUX® for Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT01218048 | Squamous Cell C... | Cetuximab Surgery Post-surgical r... Cisplatin or ca... | 18 Years - | University of Pittsburgh | |
| A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood | NCT06240689 | Locally Advance... | Sintilimab Placebo | 18 Years - 75 Years | Second Affiliated Hospital, School of Medicine, Zhejiang University | |
| Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition | NCT04454489 | Advanced Head a... Recurrent Head ... Metastatic Head... Stage III Cutan... Locally Advance... Stage IV Cutane... | Pembrolizumab (... Quad-shot palli... | 18 Years - | Wake Forest University Health Sciences | |
| Study of TARCEVA (Erlotinib) as Adjuvant Treatment for Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT01515137 | Head and Neck S... | Erlotinib Erlotinib plus ... Placebo | 18 Years - | University of Pittsburgh | |
| A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma | NCT04196283 | Advanced Solid ... | ABBV-368 Tilsotolimod Nab-paclitaxel ABBV-181 | 18 Years - | AbbVie | |
| Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT05773079 | Locally Advance... | Toripalimab | 18 Years - 70 Years | Nanfang Hospital, Southern Medical University |
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