Nervous System Diseases

Immune System Diseases

All Conditions

Symptoms and General Pathology

Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

Neoplasms

Skin and Connective Tissue Diseases

Musculoskeletal Diseases

Digestive System Diseases

Infections

Mouth and Tooth Diseases

Eye Diseases

Blood and Lymph Conditions

Heart and Blood Diseases

Diseases and Abnormalities at or Before Birth

Rare Diseases

Multiple Sclerosis

Sclerosis

Autoimmune Diseases

Diabetes Mellitus

Syndrome

Myasthenia Gravis

Diabetes Mellitus, Type 1

Scleroderma, Systemic

Scleroderma, Diffuse

Dermatomyositis

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Arthritis, Rheumatoid

Hashimoto Disease

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Hepatitis A

Hepatitis

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Ulcer

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Giant Cell Arteritis

Arteritis

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Demyelinating Autoimmune Diseases, CNS

Autoimmune Diseases of the Nervous System

Demyelinating Diseases

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Bone Diseases, Infectious

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Axial Spondyloarthritis

Spondylarthropathies

Ankylosis

Xerostomia

Salivary Gland Diseases

Mouth Diseases

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Dry Eye Syndromes

Keratoconjunctivitis Sicca

Lacrimal Apparatus Diseases

Malabsorption Syndromes

Hypopigmentation

Pigmentation Disorders

Paraneoplastic Syndromes

Paraneoplastic Syndromes, Nervous System

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Neurodegenerative Diseases

Neuromuscular Junction Diseases

Neuromuscular Diseases

Myositis

Muscular Diseases

Exophthalmos

Orbital Diseases

Goiter

Thyroid Diseases

SCAD cases will be identified based on presence of at least one diagnosis code for SCAD followed by manual verification by a trained individual, OR, inclusion in the previously validated SCAD cohort (Tweet 2012).

Potential controls will be identified based on absence of any SCAD diagnosis codes.

This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.

Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

using the Rochester Epidemiology Project Rheumatoid Arthritis cohort

Mayo Clinic

Principal Investigator

Head and Neck Neoplasms

Oculocerebral Syndrome With Hypopigmentation

Single dose stick without any active substance

Multidose moisturizing oral spray without any active substance

14-day treatment with salivary equivalent sticks

Salivary equivalent

14-day treatment with Aequasyal oral spray

Aequasyal

Biotene

Michel SALOM, Medical

The purpose of this study is to evaluate the clinical efficacy, safety and acceptability of our new oral salivary equivalent in the relief of signs and symptoms related to mouth dryness as compared to two distinct moisturizing currently marketed oral sprays (Aequasyal® \& Biotene®) in patients with xerostomia due to chronic hyposalivation.

National, multicentre, randomised, active controlled, crossover, open-label study using a 3-latin-square design.

200 evaluable patients have been recruited

A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study

Phase 4 Study Evaluating Efficacy, Safety and Acceptability of Treatment With a New Salivary Equivalent Compared to Two Moisturizing Mouth Sprays on the Improvement of Dry Mouth Symptoms and Oral Comfort in Patients With Xerostomia.

Patient evaluation through the completion of a self rated 100 mm long VAS score. Anchor points of the VAS score will be 0 representing the absence of any dry mouth symptoms and 100 representing the worst imaginable picture of dry mouth discomfort

Patient evaluation through the completion of a self rated 100 mm long VAS score.

Unither Pharmaceuticals, France

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity	NCT03941184	SCAD Addison Disease Ankylosing Spon... Antiphospholipi... Celiac Disease Crohn Disease Dermatomyositis Polymyositis Guillain-Barre ... Hepatitis, Auto... Graves Disease Hashimoto Thyro... Multiple Sclero... Myasthenia Grav... Pernicious Anem... Polymyalgia Rhe... Primary Biliary... Psoriasis Rheumatoid Arth... Systemic Sclero... Sjögren Syndrom... Systemic Lupus ... Takayasu Arteri... Type 1 Diabetes... Ulcerative Coli... Uveitis Vasculitis Vitiligo Raynaud		18 Years - 110 Years	Mayo Clinic
A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study	NCT02049112	Xerostomia Hyposalivation Head and Neck C... Sjögren Syndrom...	Salivary equiva... Aequasyal Biotene	18 Years -	Unither Pharmaceuticals, France

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