* Participants assigned to usual care will receive a packet of instructions with information about how to complete weekly surveys via a link that will be emailed to them
* Participants in both arms will be asked to complete a total of five surveys: baseline, at the end of each of three weeks, and a final survey one month later

* Participants will listen to mindfulness meditations daily over the course of three weeks.
* Participants in both arms will be asked to complete a total of five surveys: baseline, at the end of each of three weeks, and a final survey one month later

Participants assigned to either condition who do not have a personal electronic device for listening to meditations or completing survey will receive a loaned device from the study team.

Mindfulness meditation

Usual care packet

Brian Carpenter, Ph.D.

The current study examines the effects of a 3-week, at-home mindfulness mediation intervention (MMI) to address psychological and physical distress in patients with gynecologic cancer.

A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients

-On the 14-item Hospital Anxiety and Depression Scale (HADS) symptoms of anxiety (7) and depression (7) are rated on a scale from 0 (less severe) to 3 (more severe).

-Patients rate distress on a scale from 0 (no distress) to 10 (extreme distress).

-includes 9 items to measure the severity of fatigue-related symptoms on a scale from 0 (no fatigue) to 10 (fatigue as bad as you can imagine). Items include ratings of fatigue at three time points: fatigue when it is at its "worst," fatigue when it is at its "usual" level, and fatigue as it is experienced "now," in the moment.

-The Edmonton Symptoms Assessment Scale Revised is a 10-item scale that measures severity of 10 physical and psychological symptoms (e.g., nausea, drowsiness, tiredness, anxiety) on a scale from 0 (e.g., no nausea) to 10 (e.g., worst possible nausea).

-measures two emotion regulation strategies, cognitive reappraisal and expressive suppression. Respondents rate 10 items about these strategies on a scale from 1 (strongly disagree) to 7 (strongly agree).

-Will assess 20 items from four subscales (acceptance, rumination, positive reappraisal, putting into perspective, and self-blame)

-Assesses observing, describing, acting with awareness, non-judging, and non-reactivity. Participants rate 15 items on a scale from 1 (never or very rarely true) to 5 (very often or always true).

-20-item scale that measures overall compassion for the self. The items are divided into five subscales that correspond to the five components of self-compassion. Items are rated from 1 (not at all true) to 5 (always true).

-10-item measure of globally perceived stress. The measure invites participants to retrospectively report their feelings and thoughts about various topics during the last month, including "how often \[you\] have felt upset because of something that happened unexpectedly," "how often \[you\] have felt that things were going your way," and "how often \[you\] could not cope with all the things that you had to do." Participants rate each item on a scale of 0 (Never) to 5 (Very Often), and a higher score indicates greater stress.

Washington University Department of Psychological and Brain Sciences

Washington University School of Medicine

Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Digestive System Diseases

Breast Neoplasms

Prostatic Neoplasms

Colorectal Neoplasms

Breast Diseases

Skin Diseases

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

10 treatments of acupuncture over the course of 10 weeks with a +/- 7 day window

Acupuncture

10 treatments of sham acupuncture over the course of 10 weeks with a +/- 7 day window. After the 16-week study concludes patients in this group will have the option of receiving up to 10 sessions of real acupuncture; however, these sessions must be completed within 6 months of study conclusion.

Sham Acupuncture

Optional real acupuncture after 16 weeks waiting period. This arm is Closed to accrual.

16 week waiting period + optional Acupuncture

Jun Mao, MD, MSCE

This study is being done to explore whether acupuncture can improve cognitive difficulties in patients diagnosed with cancer.

Acupuncture Pilot Study for Cancer-related Cognitive Function

Cancer-related Cognitive Function Acupuncture Pilot Study (CLARITY

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

The perceived cognitive difficulties subscale score of the Functional Assessment of Cancer / FACT-Cog will be the primary outcome for the study.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients	NCT04072406	Stage III Gynec... Stage IV Gyneco...	Mindfulness med... Usual care pack...	18 Years -	Washington University School of Medicine
A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients	NCT04072406	Stage III Gynec... Stage IV Gyneco...	Mindfulness med... Usual care pack...	18 Years -	Washington University School of Medicine
Acupuncture Pilot Study for Cancer-related Cognitive Function	NCT04007770	Stage I Breast ... Stage II Breast... Stage III Breas... Stage I Colorec... Stage II Colore... Stage III Color... Gynecologic Can... Stage I Gynecol... Stage II Gyneco... Stage III Gynec... Stage I Prostat... Stage II Prosta... Stage III Prost...	Acupuncture Sham Acupunctur... 16 week waiting...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for stage iii gynecologic cancer