Neoplasms

All Conditions

Mouth and Tooth Diseases

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Head and Neck Neoplasms

Tongue Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Mouth Neoplasms

Mouth Diseases

Stomatognathic Diseases

Tongue Diseases

Tongue Cancer

Oral Cancer

3D ultrasound scanning of the resected tongue tumor will be performed. The margin analysis will be made using the 3D ultrasound image.

3D ultrasound

Fatemeh Makouei

Tobias Todsen

Tobias Todsen, MD, PhD

Complete removal of cancer encircled by a secure margin of healthy tissue is the aim of surgical oncology. A close or positive surgical margin reported by pathologist typically ends in adjuvant therapies (re-surgery and/or radiotherapy), which come with prognostic risks and financial cost. Therefore, ex-vivo imaging of removed cancer tissue may assist in margin evaluation. In this study, investigators aimed to investigate the correlation of 3D ultrasound to histopathology to assess tongue tumor margin status.

Surgical Margin Assessment by 3D Ultrasound

Feasibility of 3D Ultrasound in the Assessment of Resection Margins During Surgery for Squamous Cell Carcinoma of the Tongue: a Comparison With Histopathology

The smallest margin will be measured in mm on 3D ultrasound image of the ex-vivo surgical specimen. Correlation of the measurement to the final histopathology result will be investigated.

number of margins correctly classified as free (\> 5 mm), close (\< 5 mm) or positive (\<1 mm) margin

Rigshospitalet, Denmark

Biomedical Engineer, PhD

Lip and Oral Cavity Cancer

Patients receiving curative radiation treatment for an oral cancer.

An additional cone beam CT will be repeated at midcourse of therapy (3rd week) and during the end of therapy (5th week)

CT Scan

Patients undergoing standard of care planning for head and neck tongue cancer will have a radiation plan of the body imaged via CT scan construction with the experimental oral stent device in place

Experimental Oral Stent Device

Mark Langer, MD

The purpose of this study is to examine that ability of the experimental oral stent device to reduce the volume of mandible receiving \>55 Gy by 50%during radiation treatment as assessed duri radiation treatment planning. Patients will have CT scans at three time-points during their standard of care radiation treatment. During these visits patients will receive scans via CT or cone beam CT scan, with both the standard and experimental oral stent devices.

During radiation treatment patients will receive the standard oral stent device.

Oral Stent Device for Radiation Treatments of Oral Cancers

A Pilot Study Assessing an Oral Stent Device for Radiation Treatments of Oral Cancers

Fiducial coordinate measured (mm) on XYZ on planning CT

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Surgical Margin Assessment by 3D Ultrasound	NCT05740774	Tongue Cancer Squamous Cell C... Head and Neck C...	3D ultrasound	18 Years -	Rigshospitalet, Denmark
Surgical Margin Assessment by 3D Ultrasound	NCT05740774	Tongue Cancer Squamous Cell C... Head and Neck C...	3D ultrasound	18 Years -	Rigshospitalet, Denmark
Oral Stent Device for Radiation Treatments of Oral Cancers	NCT04041141	Tongue Tumor Tongue Cancer	CT Scan Experimental Or...	18 Years -	Indiana University

Spots Global Cancer Trial Database for tongue tumor

Every month we try and update this database with for tongue tumor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.