Digestive System Diseases

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Cola

This group of patients with Chron's disease have been diagnosed with colorectal cancer and treated surgically

excision of the whole large bowel including colon and rectum and end ileostomy fashioning

Total proctocolectomy

excision of the colon with preservation of the rectum

Total colectomy

Segmental colectomy

Bruno Sensi, MD

Giuseppe S Sica, MD, PhD

Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset.

Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible.

The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR).

Primary endpoints will be oncologic outcomes, postoperative morbidity and mortality. Secondary endpoints include quality of life (QoL).

Colorectal Cancer in Crohn's Disease

Colorectal Cancer in Crohn's Disease: Long Term Outcomes of Different Surgical Procedures

University of Rome Tor Vergata

Associate Professor, Head of Department

Symptoms and General Pathology

Colitis

Colitis, Ulcerative

Ulcer

Rectal Neoplasms

Total proctocolectomy: surgical removal of the colon, rectum, and anus

Annalisa Maroli

Humanitas R Hospital

Antonino Spinelli, MD, PhD

Michele Carvello, MD

Vittoria Bellato, MD

Janindra Warusavitarne, MD, PhD

This is a retrospective observational study to investigate the short-term surgical outcomes, and long-term oncological outcomes of patients diagnosed with Ulcerative colitis and rectal cancer.

Inflammatory Bowel Disease (IBD) is a risk factor for the development of colorectal cancer (CRC). Despite improved targeted screening and timely prophylactic resection, up to 15% of all IBD-related mortality can be attributed to CRC.

Previous reports suggest that IBD patients present with CRC at an earlier age and with more advanced disease than those with sporadic CRC. The literature is limited, however, with respect to colitis-associated rectal cancer (CARC), which has unique considerations such as surgical approach and the use of neoadjuvant therapy. Although total proctocolectomy is generally the procedure of choice for those with CARC, recent reports reported acceptable oncological outcomes after ileal pouch-anal anastomosis (IPAA) and ileorectal anastomosis (IRA).

The impact of the type of surgical procedure on the oncologic outcome in patients with CARC is not well defined.

The aim of this study is to investigate short-term surgical outcomes (postoperative complications at 30 days after surgery) and long-term oncological outcomes (disease-free survival) of CARC patients undergoing different surgical approaches.

Surgical and Oncological Outcomes in Patients With Ulcerative Colitis-associated Rectal Cancer

Surgical and Oncological Outcomes in Patients With Ulcerative Colitis Associated Rectal Cancer: a Retrospective Study

Istituto Clinico Humanitas

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Colorectal Cancer in Crohn's Disease	NCT04654494	Crohn Disease Colorectal Canc... Inflammatory Bo...	Total proctocol... Total colectomy Segmental colec...	18 Years -	University of Rome Tor Vergata
Surgical and Oncological Outcomes in Patients With Ulcerative Colitis-associated Rectal Cancer	NCT04659148	Ulcerative Coli... Rectal Cancer	Total proctocol...	18 Years -	Istituto Clinico Humanitas

Spots Global Cancer Trial Database for total proctocolectomy