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Cola

This group of patients with Chron's disease have been diagnosed with colorectal cancer and treated surgically

excision of the whole large bowel including colon and rectum and end ileostomy fashioning

Total proctocolectomy

excision of the colon with preservation of the rectum

Total colectomy

Segmental colectomy

Bruno Sensi, MD

Giuseppe S Sica, MD, PhD

Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset.

Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible.

The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR).

Primary endpoints will be oncologic outcomes, postoperative morbidity and mortality. Secondary endpoints include quality of life (QoL).

Colorectal Cancer in Crohn's Disease

Colorectal Cancer in Crohn's Disease: Long Term Outcomes of Different Surgical Procedures

University of Rome Tor Vergata

Associate Professor, Head of Department

Symptoms and General Pathology

Recurrence

Adenocarcinoma

Postoperative Complications

Anastomotic Leak

Rectal Neoplasms

Colonic Neoplasms

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Tumors located anywhere from the cecum to the proximal transverse colon.

Tumors located anywhere from the distal transverse colon to the rectosigmoid junction

Tumors located in rectosigmoid junction and in the rectum with/without the external sphincter or the levator muscles invasion

Patients with primary multiple cancer tumors

Resection of the caecum and ascending colon is appropriate for patients with tumors located anywhere from caecum to the transverse colon

Right hemicolectomy

Resection of the sigmoid colon is appropriate for patients with tumors located anywhere from the distal transverse colon to the rectosigmoid junction.

Left hemicolectomy

Resection of the sigmoid colon is appropriate for patients with tumors located in the sigmoid colon

Sigmoid colon resection

AR is appropriate for tumors located in rectosigmoid junction and in the proximal rectum

Anterior resection of the rectum

LAR is appropriate for tumors located in the middle and low rectum

Low anterior resection of the rectum

APR is appropriate for distal rectal cancers that invade the external sphincter or the levator muscles

Abdominoperineal resection

Total abdominal colectomy may be indicated for patients with primary multiple cancer tumors

Total Colectomy

Tatiana N Garmanova, PhD

Viktor V Kakotkin, MD

Mikhail A Agapov, PhD/MD

Tatyana N Garmanova, PhD/MD

Mikhail A Agapov, PhD

The study attempts to quantify the relative risks for mortality, anastomotic leakage and other early and late postoperative complications, recurrence rate, cancer-specific survival, recurrence-free survival after colorectal surgery for patients with colorectal cancer depending on the localization of the tumor.

Factors Affecting the Results of Treatment of Patients With Colorectal Cancer

Anastomotic leakage rate after colorectal resection.

AL is confirmed by one or more of the following conditions:

* fecal discharge from the pelvic drainage at any time after surgery
* rectovaginal fistula defined as fecal or mucus discharge from the vagina
* pelvic sepsis as defined by the collection of pus/ fecal material in the pelvis documented by CT scan
* contrast present outside of the anastomosis as seen by X-Ray contrast enema proctography or CT contrast enema proctography

the overall mortality after colorectal cancer surgery

The number of patients with complications after colorectal resection. All complications will be assessed according to the Clavien-Dindo classification. It consists of 7 grades (I, II, IIIa, IIIb, IVa, IVb and V).

Grade I - Any deviation from the normal postoperative course without the need for treatment.

Grade II - Requiring pharmacological treatment with drugs other than such allowed for grade I complications.

Grade III - Requiring surgical, endoscopic or radiological intervention

* IIIa - Intervention not under general anesthesia
* IIIb - Intervention under general anesthesia Grade IV - Life-threatening complication requiring IC/ICU-management
* IVa - single organ dysfunction (including dialysis)
* IVb - multiorgandysfunction Grade V - Death of a patient

All cases of colorectal cancer recurrence

The number of patients survived within 3 years after the diagnosis

The number of patients without cancer recurrence within 3 years after surgery

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Colorectal Cancer in Crohn's Disease	NCT04654494	Crohn Disease Colorectal Canc... Inflammatory Bo...	Total proctocol... Total colectomy Segmental colec...	18 Years -	University of Rome Tor Vergata
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer	NCT06050447	Colorectal Canc... Colon Cancer Rectal Cancer Colorectal Aden... Colorectal Neop... Rectal Adenocar...	Right hemicolec... Left hemicolect... Sigmoid colon r... Anterior resect... Low anterior re... Abdominoperinea... Total Colectomy	18 Years -	Immanuel Kant Baltic Federal University

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