Spots Global Cancer Trial Database for Optimizing Treatment of Stage IV Breast Cancer Through Real-Time Disease Monitoring

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Trial Identification

Brief Title: Optimizing Treatment of Stage IV Breast Cancer Through Real-Time Disease Monitoring

Official Title: Optimizing Treatment of Metastatic Breast Cancer Through Real-Time Disease Monitoring

Study ID: NCT04906369

Conditions

Anatomic Stage IV Breast Cancer AJCC v8

Metastatic Breast Carcinoma

Prognostic Stage IV Breast Cancer AJCC v8

Interventions

Biospecimen Collection

Study Description

Brief Summary: This study evaluates if blood tests can detect changes in disease status during treatment for stage IV breast cancer. Information from this study may help researchers learn more about metastatic breast cancer and how to optimize treatment.

Detailed Description: PRIMARY OBJECTIVES: I. To identify subtype-specific signatures for breast cancer using genomic positioning of plasma deoxyribonucleic acid (DNA) fragments. II. To validate changes in circulating tumor-derived DNA (ctDNA) levels as a biomarker for treatment monitoring in patients with metastatic breast cancer. OUTLINE: Patients undergo collection of blood samples at baseline, 2 weeks after the start of treatment, and at the beginning of each new treatment cycle.