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Spots Global Cancer Trial Database for De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

Official Title: A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Study ID: NCT03952585

Study Description

Brief Summary: This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated with smoking. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial is being done to see if a reduced dose of radiation therapy and nivolumab works as well as standard dose radiation therapy and cisplatin in treating patients with oropharyngeal cancer.

Detailed Description: PRIMARY OBJECTIVES: I. To demonstrate non-inferiority in terms of progression-free survival (PFS) of concurrent reduced-dose radiation therapy (RT) with cisplatin or concurrent reduced-dose radiation therapy with nivolumab to the current standard of care (standard-dose RT with cisplatin). (Phase II) (Arm 2 \[concurrent reduced-dose RT with cisplatin\] was dropped after interim futility analysis in phase II.) II. To demonstrate non-inferiority in terms of progression-free survival (PFS) of concurrent reduced-dose radiation therapy (RT) with nivolumab to the current standard of care (standard-dose RT with cisplatin). (Phase II) III. To demonstrate co-primary endpoints of non-inferiority of PFS and superiority of quality of life (QOL) as measured by the MD Anderson Dysphagia Inventory (MDADI) of concurrent reduced-dose radiation with cisplatin or concurrent reduced-dose radiation with nivolumab to the current standard of care (standard-dose RT with cisplatin). (Phase III) (Arm 2 \[concurrent reduced-dose RT with cisplatin\] was dropped after interim futility analysis in phase II.) IV. To demonstrate co-primary endpoints of non-inferiority of PFS and superiority of quality of life (QOL) as measured by the MD Anderson Dysphagia Inventory \[MDADI\] of concurrent reduced-dose radiation with nivolumab to the current standard of care (standard-dose RT with cisplatin). (Phase III) SECONDARY OBJECTIVES: I. To compare patterns of failure (local and regional relapse versus distant) and overall survival between the experimental arm and the control arm. II. To assess long term PFS, overall survival, and toxicity between the experimental arm and the control arm. III. To determine acute and late toxicity profiles as measured by the Common Terminology Criteria for Adverse Events (CTCAE). IV. To explore the symptomatic adverse events (AEs) for tolerability of each treatment arm as measured by the Patient-Reported Outcomes (PRO)-CTCAE. V. To compare changes in patient-reported outcomes (Hearing Handicap Inventory for Adults-Screening \[HHIA-S\], European Organization for Research and Treatment of Cancer \[EORTC\]-Quality of Life Questionnaire \[QLQ\]30) between the experimental arm and the control arm. VI. To assess the association of fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/computed tomography (CT) at baseline with locoregional control and PFS. VII. To estimate the negative predictive value of the 12-14 weeks post-radiation therapy (RT) FDG-PET/CT in terms of locoregional control rates and PFS rates at 1 and 2 years. EXPLORATORY OBJECTIVES: I. To collect blood and tissue specimens for future translation research. II. To optimize radiotherapy treatment plan quality assurance methodology for radiotherapy planning and imaging. III. To compare changes in patient-reported outcomes (European Quality of Life Five Dimension Five Level Scale \[EQ-5D-5L\]) between the experimental arm and the control arm. IV. To collect Modified Barium Swallow (MBS) data for future review and analysis. OUTLINE: PHASE II: Patients are randomized to 1 of 3 arms. ARM I: Patients undergo intensity modulated radiation therapy (IMRT) or image-guided radiation therapy (IGRT) over 6 fractions per week and receive cisplatin intravenously (IV) over 30-60 minutes on days 1 and 22. Treatment continues for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients receive fludeoxyglucose F-18 (FDG) and undergo positron emission tomography (PET)/computed tomography (CT) or CT during screening and during follow up, and undergo magnetic resonance imaging (MRI) during follow up. Patients may also undergo tissue biopsy and blood sample collection throughout the study. ARM II (CLOSED TO ACCRUAL 03-FEB-2023): Patients undergo reduced dose IMRT or IGRT once daily (QD) over 5 fractions per week and receive cisplatin IV over 30-60 minutes on days 1 and 22. Treatment continues for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients receive FDG and undergo PET/CT or CT during screening and during follow up, and undergo MRI during follow up. Patients may also undergo tissue biopsy and blood sample collection throughout the study. ARM III: Beginning 1 week prior to radiation, patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks (14 days) for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo reduced dose IMRT or IGRT over 6 fractions per week for 5 weeks in the absence of disease progression or unacceptable toxicity. Patients receive FDG and undergo PET/CT or CT during screening and during follow up, and undergo MRI during follow up. Patients may also undergo tissue biopsy and blood sample collection throughout the study. PHASE III: Patients are randomized to Arm I and/or Arm III. After completion of study treatment, patients are followed up at 12-14 weeks, every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

Banner MD Anderson Cancer Center, Gilbert, Arizona, United States

Banner University Medical Center - Tucson, Tucson, Arizona, United States

University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States

Kaiser Permanente-Deer Valley Medical Center, Antioch, California, United States

PCR Oncology, Arroyo Grande, California, United States

Sutter Auburn Faith Hospital, Auburn, California, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States

AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California, United States

Tower Cancer Research Foundation, Beverly Hills, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Kaiser Permanente Dublin, Dublin, California, United States

UC San Diego Health System - Encinitas, Encinitas, California, United States

Kaiser Permanente-Fremont, Fremont, California, United States

Fresno Cancer Center, Fresno, California, United States

Kaiser Permanente-Fresno, Fresno, California, United States

City of Hope at Irvine Lennar, Irvine, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

City of Hope Antelope Valley, Lancaster, California, United States

Los Angeles General Medical Center, Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Cedars Sinai Medical Center, Los Angeles, California, United States

Fremont - Rideout Cancer Center, Marysville, California, United States

Kaiser Permanente-Modesto, Modesto, California, United States

Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States

Kaiser Permanente Oakland-Broadway, Oakland, California, United States

Kaiser Permanente-Oakland, Oakland, California, United States

Palo Alto Medical Foundation Health Care, Palo Alto, California, United States

Stanford Cancer Institute Palo Alto, Palo Alto, California, United States

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California, United States

Kaiser Permanente- Marshall Medical Offices, Redwood City, California, United States

Kaiser Permanente-Richmond, Richmond, California, United States

Rohnert Park Cancer Center, Rohnert Park, California, United States

Kaiser Permanente-Roseville, Roseville, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States

Sutter Roseville Medical Center, Roseville, California, United States

The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California, United States

Kaiser Permanente Downtown Commons, Sacramento, California, United States

Sutter Medical Center Sacramento, Sacramento, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Kaiser Permanente-South Sacramento, Sacramento, California, United States

South Sacramento Cancer Center, Sacramento, California, United States

UC San Diego Medical Center - Hillcrest, San Diego, California, United States

Naval Medical Center -San Diego, San Diego, California, United States

Kaiser Permanente-San Francisco, San Francisco, California, United States

UCSF Medical Center-Mission Bay, San Francisco, California, United States

Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States

Stanford Cancer Center South Bay, San Jose, California, United States

Kaiser Permanente San Leandro, San Leandro, California, United States

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California, United States

Kaiser San Rafael-Gallinas, San Rafael, California, United States

Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States

Kaiser Permanente-Santa Rosa, Santa Rosa, California, United States

City of Hope South Pasadena, South Pasadena, California, United States

Kaiser Permanente Cancer Treatment Center, South San Francisco, California, United States

Kaiser Permanente-South San Francisco, South San Francisco, California, United States

Kaiser Permanente-Stockton, Stockton, California, United States

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California, United States

City of Hope South Bay, Torrance, California, United States

Torrance Memorial Physician Network - Cancer Care, Torrance, California, United States

Torrance Memorial Medical Center, Torrance, California, United States

City of Hope Upland, Upland, California, United States

Kaiser Permanente Medical Center-Vacaville, Vacaville, California, United States

Kaiser Permanente-Vallejo, Vallejo, California, United States

Kaiser Permanente-Walnut Creek, Walnut Creek, California, United States

Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United States

UCHealth University of Colorado Hospital, Aurora, Colorado, United States

Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States

Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado, United States

UCHealth Memorial Hospital Central, Colorado Springs, Colorado, United States

Memorial Hospital North, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado, United States

UCHealth Greeley Hospital, Greeley, Colorado, United States

Littleton Adventist Hospital, Littleton, Colorado, United States

Medical Center of the Rockies, Loveland, Colorado, United States

Parker Adventist Hospital, Parker, Colorado, United States

Hartford Hospital, Hartford, Connecticut, United States

Delaware Clinical and Laboratory Physicians PA, Newark, Delaware, United States

Helen F Graham Cancer Center, Newark, Delaware, United States

Medical Oncology Hematology Consultants PA, Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida, United States

UM Sylvester Comprehensive Cancer Center at Coral Springs, Coral Springs, Florida, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

Jupiter Medical Center, Jupiter, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States

Miami Cancer Institute, Miami, Florida, United States

UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida, United States

Orlando Health Cancer Institute, Orlando, Florida, United States

Moffitt Cancer Center-International Plaza, Tampa, Florida, United States

Moffitt Cancer Center - McKinley Campus, Tampa, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

Moffitt Cancer Center at Wesley Chapel, Wesley Chapel, Florida, United States

Grady Health System, Atlanta, Georgia, United States

Emory University Hospital Midtown, Atlanta, Georgia, United States

Hawaii Cancer Care - Westridge, 'Aiea, Hawaii, United States

Pali Momi Medical Center, 'Aiea, Hawaii, United States

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii, United States

Queen's Cancer Cenrer - POB I, Honolulu, Hawaii, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Honolulu, Hawaii, United States

University of Hawaii Cancer Center, Honolulu, Hawaii, United States

Hawaii Cancer Care Inc-Liliha, Honolulu, Hawaii, United States

Kuakini Medical Center, Honolulu, Hawaii, United States

Queen's Cancer Center - Kuakini, Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii, United States

Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho, United States

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

Advocate Good Shepherd Hospital, Barrington, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Centralia Oncology Clinic, Centralia, Illinois, United States

Northwestern University, Chicago, Illinois, United States

Rush University Medical Center, Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

AMG Crystal Lake - Oncology, Crystal Lake, Illinois, United States

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois, United States

Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States

Crossroads Cancer Center, Effingham, Illinois, United States

Advocate Sherman Hospital, Elgin, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois, United States

NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois, United States

NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

UW Health Carbone Cancer Center Rockford, Rockford, Illinois, United States

Memorial Hospital East, Shiloh, Illinois, United States

Southern Illinois University School of Medicine, Springfield, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, United States

Illinois CancerCare - Washington, Washington, Illinois, United States

IU Health North Hospital, Carmel, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

Sidney and Lois Eskenazi Hospital, Indianapolis, Indiana, United States

Mercy Cancer Center-West Lakes, Clive, Iowa, United States

Mission Cancer and Blood - West Des Moines, Clive, Iowa, United States

Greater Regional Medical Center, Creston, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Mission Cancer and Blood - Des Moines, Des Moines, Iowa, United States

Broadlawns Medical Center, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Mission Cancer and Blood - Laurel, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

Methodist West Hospital, West Des Moines, Iowa, United States

Mercy Medical Center-West Lakes, West Des Moines, Iowa, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

Olathe Health Cancer Center, Olathe, Kansas, United States

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas, United States

Salina Regional Health Center, Salina, Kansas, United States

University of Kansas Health System Saint Francis Campus, Topeka, Kansas, United States

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas, United States

University of Kentucky/Markey Cancer Center, Lexington, Kentucky, United States

Jewish Hospital, Louisville, Kentucky, United States

Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky, United States

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States

Norton Brownsboro Hospital and Medical Campus, Louisville, Kentucky, United States

LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana, United States

Our Lady of the Lake Physician Group, Baton Rouge, Louisiana, United States

Louisiana Hematology Oncology Associates LLC, Baton Rouge, Louisiana, United States

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States

East Jefferson General Hospital, Metairie, Louisiana, United States

MaineHealth Coastal Cancer Treatment Center, Bath, Maine, United States

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford, Biddeford, Maine, United States

Maine Medical Center-Bramhall Campus, Portland, Maine, United States

Penobscot Bay Medical Center, Rockport, Maine, United States

MaineHealth Cancer Care Center of York County, Sanford, Maine, United States

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford, Sanford, Maine, United States

Maine Medical Center- Scarborough Campus, Scarborough, Maine, United States

Maine Medical Partners - South Portland, South Portland, Maine, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

UM Upper Chesapeake Medical Center, Bel Air, Maryland, United States

Boston Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States

McLaren Cancer Institute-Bay City, Bay City, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan, United States

Trinity Health Medical Center - Brighton, Brighton, Michigan, United States

Henry Ford Cancer Institute-Downriver, Brownstown, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan, United States

Trinity Health Medical Center - Canton, Canton, Michigan, United States

Caro Cancer Center, Caro, Michigan, United States

Saint Joseph Mercy Chelsea, Chelsea, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan, United States

McLaren Cancer Institute-Clarkston, Clarkston, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Henry Ford Medical Center-Fairlane, Dearborn, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States

McLaren Cancer Institute-Flint, Flint, Michigan, United States

Singh and Arora Hematology Oncology PC, Flint, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan, United States

Mid-Michigan Physicians-Lansing, Lansing, Michigan, United States

University of Michigan Health - Sparrow Lansing, Lansing, Michigan, United States

McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette, Michigan, United States

McLaren Cancer Institute-Macomb, Mount Clemens, Michigan, United States

Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan, United States

Henry Ford Medical Center-Columbus, Novi, Michigan, United States

McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan, United States

McLaren-Port Huron, Port Huron, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan, United States

Henry Ford Macomb Health Center - Shelby Township, Shelby, Michigan, United States

Ascension Saint Joseph Hospital, Tawas City, Michigan, United States

Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan, United States

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan, United States

University of Michigan Health - West, Wyoming, Michigan, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan, United States

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States

Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota, United States

Essentia Health - Deer River Clinic, Deer River, Minnesota, United States

Essentia Health Cancer Center, Duluth, Minnesota, United States

Essentia Health Saint Mary's Medical Center, Duluth, Minnesota, United States

Miller-Dwan Hospital, Duluth, Minnesota, United States

Essentia Health Hibbing Clinic, Hibbing, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Essentia Health Sandstone, Sandstone, Minnesota, United States

Essentia Health Virginia Clinic, Virginia, Minnesota, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, United States

Parkland Health Center - Farmington, Farmington, Missouri, United States

Freeman Health System, Joplin, Missouri, United States

University of Kansas Cancer Center - North, Kansas City, Missouri, United States

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri, United States

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Siteman Cancer Center-South County, Saint Louis, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Benefis Sletten Cancer Institute, Great Falls, Montana, United States

CHI Health Good Samaritan, Kearney, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Renown Regional Medical Center, Reno, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Community Medical Center, Toms River, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

New Mexico Oncology Hematology Consultants, Albuquerque, New Mexico, United States

Sands Cancer Center, Canandaigua, New York, United States

Noyes Memorial Hospital/Myers Cancer Center, Dansville, New York, United States

Upstate Cancer Center at Oswego, Oswego, New York, United States

Highland Hospital, Rochester, New York, United States

University of Rochester, Rochester, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

State University of New York Upstate Medical University, Syracuse, New York, United States

SUNY Upstate Medical Center-Community Campus, Syracuse, New York, United States

Upstate Cancer Center at Verona, Verona, New York, United States

Wilmot Cancer Institute at Webster, Webster, New York, United States

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, United States

Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States

Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina, United States

Atrium Health University City/LCI-University, Charlotte, North Carolina, United States

Levine Cancer Institute-Ballantyne, Charlotte, North Carolina, United States

Wake Forest University at Clemmons, Clemmons, North Carolina, United States

Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina, United States

CaroMont Regional Medical Center, Gastonia, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

Novant Health Cancer Institute - Huntersville, Huntersville, North Carolina, United States

Novant Health Presbyterian Medical Center Huntersville, Huntersville, North Carolina, United States

Novant Health Cancer Institute - Kernersville, Kernersville, North Carolina, United States

Novant Health Cancer Institute - Matthews, Matthews, North Carolina, United States

Atrium Health Union/LCI-Union, Monroe, North Carolina, United States

Novant Health Cancer Institute - Mooresville, Mooresville, North Carolina, United States

Novant Health Cancer Institute - Mount Airy, Mount Airy, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, United States

Novant Health Cancer Institute - Rowan, Salisbury, North Carolina, United States

Novant Health Cancer Institute - Statesville, Statesville, North Carolina, United States

Wake Forest Baptist Health - Hematology Oncology - Statesville, Statesville, North Carolina, United States

Novant Cancer Institute Radiation Oncology - Supply, Supply, North Carolina, United States

Novant Health Cancer Institute - Thomasville, Thomasville, North Carolina, United States

Novant Health Cancer Institute - Wilkesboro, Wilkesboro, North Carolina, United States

Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro, North Carolina, United States

Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington, North Carolina, United States

Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina, United States

Novant Health Forsyth Medical Center, Winston-Salem, North Carolina, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Sanford Broadway Medical Center, Fargo, North Dakota, United States

Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States

Summa Health System - Akron Campus, Akron, Ohio, United States

UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio, United States

Summa Health System - Barberton Campus, Barberton, Ohio, United States

Geauga Hospital, Chardon, Ohio, United States

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

MetroHealth Medical Center, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio, United States

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States

Summa Health Medina Medical Center, Medina, Ohio, United States

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio, United States

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio, United States

University Hospitals Parma Medical Center, Parma, Ohio, United States

Mercy Health Perrysburg Cancer Center, Perrysburg, Ohio, United States

University Hospitals Portage Medical Center, Ravenna, Ohio, United States

North Coast Cancer Care, Sandusky, Ohio, United States

Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States

ProMedica Flower Hospital, Sylvania, Ohio, United States

Mercy Health - Saint Vincent Hospital, Toledo, Ohio, United States

Mercy Health - Saint Anne Hospital, Toledo, Ohio, United States

Mercy Health Sylvania Radiation Oncology Center, Toledo, Ohio, United States

University of Cincinnati Cancer Center-West Chester, West Chester, Ohio, United States

UH Seidman Cancer Center at Saint John Medical Center, Westlake, Ohio, United States

UHHS-Westlake Medical Center, Westlake, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Kaiser Permanente Northwest, Portland, Oregon, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

UPMC Altoona, Altoona, Pennsylvania, United States

UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania, United States

Carlisle Regional Cancer Center, Carlisle, Pennsylvania, United States

Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania, United States

Chambersburg Hospital, Chambersburg, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center, East Norriton, Pennsylvania, United States

Ephrata Cancer Center, Ephrata, Pennsylvania, United States

UPMC Hillman Cancer Center Erie, Erie, Pennsylvania, United States

UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania, United States

Fox Chase Cancer Center Buckingham, Furlong, Pennsylvania, United States

Adams Cancer Center, Gettysburg, Pennsylvania, United States

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania, United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania, United States

Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania, United States

Lewistown Hospital, Lewistown, Pennsylvania, United States

UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania, United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania, United States

Forbes Hospital, Monroeville, Pennsylvania, United States

UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania, United States

UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Jefferson Torresdale Hospital, Philadelphia, Pennsylvania, United States

Temple University Hospital, Philadelphia, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Saint Margaret, Pittsburgh, Pennsylvania, United States

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Passavant Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania, United States

Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania, United States

UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania, United States

UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania, United States

UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania, United States

Reading Hospital, West Reading, Pennsylvania, United States

Wexford Health and Wellness Pavilion, Wexford, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania, United States

Divine Providence Hospital, Williamsport, Pennsylvania, United States

Asplundh Cancer Pavilion, Willow Grove, Pennsylvania, United States

WellSpan Health-York Cancer Center, York, Pennsylvania, United States

WellSpan Health-York Hospital, York, Pennsylvania, United States

UPMC Memorial, York, Pennsylvania, United States

Medical University of South Carolina, Charleston, South Carolina, United States

Gibbs Cancer Center-Gaffney, Gaffney, South Carolina, United States

Tidelands Georgetown Memorial Hospital, Georgetown, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States

Saint Francis Cancer Center, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States

Gibbs Cancer Center-Pelham, Greer, South Carolina, United States

Rock Hill Radiation Therapy Center, Rock Hill, South Carolina, United States

Levine Cancer Institute-Rock Hill, Rock Hill, South Carolina, United States

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States

Spartanburg Medical Center, Spartanburg, South Carolina, United States

MGC Hematology Oncology-Union, Union, South Carolina, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

The West Clinic - Wolf River, Germantown, Tennessee, United States

University of Tennessee - Knoxville, Knoxville, Tennessee, United States

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

The Don and Sybil Harrington Cancer Center, Amarillo, Texas, United States

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah, United States

Farmington Health Center, Farmington, Utah, United States

Logan Regional Hospital, Logan, Utah, United States

Intermountain Medical Center, Murray, Utah, United States

McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center, Provo, Utah, United States

Riverton Hospital, Riverton, Utah, United States

Saint George Regional Medical Center, Saint George, Utah, United States

Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

Dartmouth Cancer Center - North, Saint Johnsbury, Vermont, United States

Inova Schar Cancer Institute, Fairfax, Virginia, United States

Inova Fair Oaks Hospital, Fairfax, Virginia, United States

Naval Medical Center - Portsmouth, Portsmouth, Virginia, United States

VCU Massey Cancer Center at Stony Point, Richmond, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Valley Medical Center, Renton, Washington, United States

Swedish Medical Center-Ballard Campus, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

Ascension Saint Elizabeth Hospital, Appleton, Wisconsin, United States

Duluth Clinic Ashland, Ashland, Wisconsin, United States

Northwest Wisconsin Cancer Center, Ashland, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield, Wisconsin, United States

Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin, United States

Ascension Calumet Hospital, Chilton, Wisconsin, United States

HSHS Sacred Heart Hospital, Eau Claire, Wisconsin, United States

Ascension Saint Francis - Reiman Cancer Center, Franklin, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Franklin, Franklin, Wisconsin, United States

Aurora Health Care Germantown Health Center, Germantown, Wisconsin, United States

Aurora Cancer Care-Grafton, Grafton, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

Essentia Health-Hayward Clinic, Hayward, Wisconsin, United States

University of Wisconsin Carbone Cancer Center Johnson Creek, Johnson Creek, Wisconsin, United States

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin, United States

Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin, United States

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin, United States

Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Saint Joseph Campus, Milwaukee, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin, United States

Ascension Saint Francis Hospital, Milwaukee, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States

Ascension Mercy Hospital, Oshkosh, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

Ascension All Saints Hospital, Racine, Wisconsin, United States

Aurora Cancer Care-Racine, Racine, Wisconsin, United States

Ascension Saint Mary's Hospital, Rhinelander, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, United States

Essentia Health-Spooner Clinic, Spooner, Wisconsin, United States

Ascension Saint Michael's Hospital, Stevens Point, Wisconsin, United States

Aurora Medical Center in Summit, Summit, Wisconsin, United States

Essentia Health Saint Mary's Hospital - Superior, Superior, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Aurora West Allis Medical Center, West Allis, Wisconsin, United States

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin, United States

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin, United States

University Health Network-Princess Margaret Hospital, Toronto, Ontario, Canada

Contact Details

Name: Sue S Yom

Affiliation: NRG Oncology

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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