Spots Global Cancer Trial Database for Predictive Value of Progastrin Titer at Diagnosis and of Progastrin Kinetics During Treatment in Cancer Patients
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Trial Identification
Brief Title: Predictive Value of Progastrin Titer at Diagnosis and of Progastrin Kinetics During Treatment in Cancer Patients
Official Title: Predictive Value of Progastrin Titer at Diagnosis and of Progastrin Kinetics During Treatment in Cancer Patients
Study ID: NCT03787056
Interventions
Study Description
Brief Summary: Progastrin is a pro-hormone that, in physiological conditions, is maturated in gastrin in G cells of the stomach. The role of the gastrin is to stimulate the secretion of gastric acids during digestion. It is also important for the regulation of cell growth of the gastric mucosal. In a healthy person, progastrin is not detectable in the peripheral blood. However, progastrin is abnormally released in the blood of patients with different cancers (colorectal, gastric, ovarian, breast, cervix uterus, melanoma...) The gene GAST coding for progastrin is a direct target gene of the WNT/ß-catenin oncogenic pathway. The activation of this oncogenic pathway is an early event in cancer development. Chronic activation of the WNT/ß-catenin oncogenic pathway occurs in almost all human solid tumors and is a central mechanism in cancer biology that induces cellular proliferation, blocking of differentiation leading to primary tumor growth and metastasis formation. Progastrin measured in the peripheral blood of patients on treatments, could be a new powerful marker for diagnosis and prognosis at different stages.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Service de NEURO-ONCOLOGIE du Groupement Hospitalier EST, Bron, , France
Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE de l'hôpital de la Croix-Rousse, Lyon, , France
Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE de l'Hôpital E. Herriot, Lyon, , France
Service d'Oto-Rhino-Laryngologie de l'Hôpital de la Croix-Rousse, Lyon, , France
Service d'Urologie de l'Hôpital E. Herriot, Lyon, , France
Service de Gynécologie de l'hôpital de la Croix-Rousse, Lyon, , France
Service de Gynécologie du Groupement Hospitalier Est, Lyon, , France
Service de Pneumologie de l'hôpital de la Croix-Rousse, Lyon, , France
Service de Pneumologie du Groupement Hospitalier Est, Lyon, , France
Service d'Hématologie de l'Hôpital Lyon Sud, Pierre-Bénite, , France
Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE du Centre Hospitalier Lyon Sud, Pierre-Bénite, , France
Service d'Oncologie médicale du Centre hospitalier Lyon Sud, Pierre-Bénite, , France
Service d'Urologie de l'hôpital Lyon Sud, Pierre-Bénite, , France
Service de Chirurgie de l'hôpital Lyon Sud, Pierre-Bénite, , France
Service de Dermatologie de l'hôpital Lyon Sud, Pierre-Bénite, , France
Service de Gynécologie de l'hôpital Lyon Sud, Pierre-Bénite, , France
Service de Pneumologie de l'Hôpital Lyon Sud, Pierre-Bénite, , France
Contact Details
Name: Benoit YOU, MD
Affiliation: Hospices Civils de Lyon
Role: PRINCIPAL_INVESTIGATOR
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