Spots Global Cancer Trial Database for PRecISion Medicine for Children With Cancer
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Trial Identification
Brief Title: PRecISion Medicine for Children With Cancer
Official Title: A Multicenter Prospective Study of the Feasibility and Clinical Value of a Diagnostic Service for Identifying Therapeutic Targets and Recommending Personalised Treatment for Children and Adolescents With High-risk Cancer
Study ID: NCT03336931
Interventions
Study Description
Brief Summary: This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.
Detailed Description: This is a multicentre study conducted under the Zero Childhood Cancer Program. The study will be enrolling patients under the age of 21 with high-risk cancer over 3 years from cancer centres in Australia. Patient's cancer cells will be tested for genetic abnormalities (mutations) and undergoing drug testing in highly specialised laboratories. A Multidisciplinary Tumour Board comprising of oncologists, clinical geneticists and scientists will then discuss the results of each case and determine whether a personalised medicine recommendation can be made. A report describing the results and Tumour Board recommendation (if any) will be provided to the patient's treating doctor. It is always at the discretion of the treating doctor whether to alter the patient's management based on the information arising from this research project.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
John Hunter Children's Hospital, Newcastle, New South Wales, Australia
Sydney Children's Hospital, Randwick, Sydney, New South Wales, Australia
The Children's Hospital at Westmead, Sydney, New South Wales, Australia
Queensland Children's Hospital, Brisbane, Queensland, Australia
Women's and Children's Hospital, Adelaide, South Australia, Australia
Royal Children's Hospital, Melbourne, Victoria, Australia
Monash Children's Hospital, Melbourne, Victoria, Australia
Perth Children's Hospital, Perth, Western Australia, Australia
Contact Details
Name: A/Prof David Ziegler, MBBS
Affiliation: Sydney Children's Hospitals Network
Role: PRINCIPAL_INVESTIGATOR
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