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Spots Global Cancer Trial Database for Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology

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Trial Identification

Brief Title: Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology

Official Title: Neoadjuvant Therapy for Locally Advanced Esophageal Cancer: Impact on Cardiopulmonary Physiology, Short- and Long-term Morbidity

Study ID: NCT03462524

Interventions

Esophagectomy

Study Description

Brief Summary: Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs. In a recent modern international collaborative series of 2704 patients from high-volume centers, with an approximate equal mix of open and minimally invasive approaches, respiratory complications were evident in 28% of patients, pneumonia in 15%, and respiratory failure in 7%.1 In other series, respiratory failure is reported in up to 15% of patients and is the most common cause of mortality. Prediction of risk and prevention of respiratory morbidity is therefore of considerable importance, and in this context baseline assessment of respiratory physiology compliments clinical assessment, history and enhanced recovery pathways representing key elements of current patient management. In this study, which will include all prospective patients with locally advanced esophageal cancer treated at a National Center, pulmonary function will be systematically measured before and after neoadjuvant therapy. The investigators seek to evaluate the incidence of radiation induced lung injury (RILI), as well as subclinical changes in pulmonary physiology that may be linked to postoperative complications, and quality-of-life in survivorship, and to compare cohorts who received radiation therapy or chemotherapy alone, preoperatively.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Department of Surgery, St. James's Hospital, Dublin, , Ireland

Wellcome Trust-Health Research Board Clinical Research Facility, St. James's Hospital, Dublin, , Ireland

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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