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Brief Title: PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial
Official Title: PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies (POPCORN) Trial
Study ID: NCT06397560
Brief Summary: The purpose of this research study is to see if a specific type of radiation therapy, called "proton pulsed reduced dose rate" or "PRDR radiotherapy" has any benefits at dose levels and number of fractions thought to be acceptable in earlier research studies. The researchers want to find out what effects (good and bad) PRDR has on people with cancer in the brain called a "recurrent high-grade glioma" meaning that it grows fast, can spread quickly, and it has come back or gotten worse after being treated previously.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Lynn Cancer Institute at Baptist Health, Inc., Boca Raton, Florida, United States
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida, United States
Name: Rupesh Kotecha, M.D.
Affiliation: Miami Cancer Institute at Baptist Health, Inc.
Role: PRINCIPAL_INVESTIGATOR