Spots Global Cancer Trial Database for recurrent glioma

Every month we try and update this database with for recurrent glioma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)	NCT03526250	Advanced Malign... Recurrent Child... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Kidne... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Rhabd... Recurrent Rhabd... Recurrent Soft ... Refractory Epen... Refractory Ewin... Refractory Glio... Refractory Hepa... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Medu... Refractory Neur... Refractory Non-... Refractory Oste... Refractory Peri... Refractory Rhab... Refractory Rhab... Refractory Soft...	Laboratory Biom... Palbociclib Pharmacological...	12 Months - 21 Years	National Cancer Institute (NCI)
Role of Surgery in Treatment of Recurrent Brian Glioma:Prognostic Factors and Outcome	NCT04562077	Recurrent Gliom... Glioma, Maligna...		-	Assiut University
Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma	NCT05045027	Glioma Malignant Gliom... Recurrent Gliom... Recurrent Malig...	Biospecimen Col... Diagnostic Imag... Magnetic Resona...	18 Years -	Jonsson Comprehensive Cancer Center
Carbon Ion Radiotherapy for Recurrent Gliomas	NCT01166308	Glioma	Carbon Ion Radi... Fractionated St...	18 Years -	University Hospital Heidelberg
A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas	NCT04089449	Advanced Solid ... Recurrent Gliom...	PRT811	18 Years -	Prelude Therapeutics
Image Guided Reirradiation of High-grade Glioma	NCT02025231	Malignant Gliom... Glioblastoma	External beam r...	18 Years -	Rigshospitalet, Denmark
Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma	NCT01290692	Grade IV Glioma Grade IV Astroc... Glioblastoma Mu...	TVI-Brain-1	18 Years -	TVAX Biomedical
Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)	NCT03698994	Advanced Malign... Recurrent Epend... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Histi... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Prima... Recurrent Rhabd... Recurrent Rhabd... Recurrent Soft ... Refractory Epen... Refractory Ewin... Refractory Glio... Refractory Hepa... Refractory Hist... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Medu... Refractory Neur... Refractory Non-... Refractory Oste... Refractory Peri... Refractory Prim... Refractory Rhab... Refractory Rhab... Refractory Soft... Wilms Tumor	Pharmacokinetic... Ulixertinib	12 Months - 21 Years	National Cancer Institute (NCI)
CARv3-TEAM-E T Cells in Glioblastoma	NCT05660369	Glioblastoma Malignant Gliom... Recurrent Gliob... Recurrent Gliom...	CARv3-TEAM-E T ...	18 Years -	Massachusetts General Hospital
VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM	NCT03149575	Glioblastoma Mu... Glioblastoma Glioma GBM Brain Cancer	VAL-083, Dianhy... Physician's Cho... Physician's Cho... Physician's Cho...	18 Years -	Kintara Therapeutics, Inc.
Low-dose Bevacizumab With HSRT vs BVZ Alone for GBM at First Recurrence	NCT05611645	Glioma Recurrent Gliom...	Hypofractionate... Bevacizumab	18 Years - 70 Years	Huashan Hospital
ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas	NCT05609994	Low Grade Gliom...	PEPIDH1M vaccin...	18 Years -	Duke University
Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor (Glioblastoma)	NCT03463733	Glioma Glioblastoma	Hydroxyurea Temozolomide	-	Amsterdam UMC, location VUmc
Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations	NCT03212274	Advanced Malign... Glioblastoma Recurrent Chola... Recurrent Gliom... Recurrent Malig... WHO Grade 2 Gli... WHO Grade 3 Gli...	Biopsy Biospecimen Col... Computed Tomogr... Magnetic Resona... Olaparib	18 Years -	National Cancer Institute (NCI)
Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma	NCT01580969	Recurrent Gliom...	Bevacizumab Minocycline Radiation	18 Years -	University of Utah
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)	NCT03213678	Advanced Malign... Ann Arbor Stage... Ann Arbor Stage... Malignant Gliom... Recurrent Epend... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Prima... Recurrent Rhabd... Recurrent Soft ... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Neur... Refractory Non-... Refractory Prim... Rhabdoid Tumor Stage III Osteo... Stage III Soft ... Stage IV Osteos... Stage IV Soft T... Stage IVA Osteo... Stage IVB Osteo... Wilms Tumor	Biospecimen Col... Computed Tomogr... FDG-Positron Em... Magnetic Resona... Samotolisib X-Ray Imaging	12 Months - 21 Years	National Cancer Institute (NCI)
Amino-acid PET Versus MRI Guided Re-irradiation in Patients With Recurrent Glioblastoma Multiforme	NCT01252459	Recurrent Gliom...	Radiation Thera... Radiation Thera...	18 Years -	University Hospital Freiburg
Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors	NCT01324635	Recurrent Gliom... High-grade Meni... Brain Metastasi...	Panobinostat Stereotactic bo... Quality-of-life... Stereotactic ra...	18 Years -	Thomas Jefferson University
Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)	NCT03698994	Advanced Malign... Recurrent Epend... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Histi... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Prima... Recurrent Rhabd... Recurrent Rhabd... Recurrent Soft ... Refractory Epen... Refractory Ewin... Refractory Glio... Refractory Hepa... Refractory Hist... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Medu... Refractory Neur... Refractory Non-... Refractory Oste... Refractory Peri... Refractory Prim... Refractory Rhab... Refractory Rhab... Refractory Soft... Wilms Tumor	Pharmacokinetic... Ulixertinib	12 Months - 21 Years	National Cancer Institute (NCI)
PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial	NCT06397560	Glioma Glioma, Maligna... Recurrent Gliom...	PRDR	18 Years -	Baptist Health South Florida
Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases	NCT03796273	Anatomic Stage ... Astrocytoma Breast Carcinom... Glioma Invasive Breast... Oligodendroglio... Prognostic Stag... Recurrent Gliom...	Best Practice Ketoconazole	18 Years -	Wake Forest University Health Sciences
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients	NCT02796261	Anaplastic Astr... Recurrent Anapl...	Eflornithine Lomustine Lomustine	18 Years -	Orbus Therapeutics, Inc.
Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd	NCT04740190	Recurrent Gliom... Recurrent Gliob... Poly ADP Ribose... PTEN Gene Inact... IDH Mutation	Talazoparib	18 Years -	The University of Hong Kong
Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)	NCT04164901	Grade 2 Glioma Residual Glioma Recurrent Gliom...	Vorasidenib Matching Placeb...	12 Years -	Servier
Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas	NCT01229644	Glioma	Crenolanib (CP-...	18 Years -	Arog Pharmaceuticals, Inc.
ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas	NCT05609994	Low Grade Gliom...	PEPIDH1M vaccin...	18 Years -	Duke University
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)	NCT02465060	Advanced Lympho... Advanced Malign... Bladder Carcino... Breast Carcinom... Cervical Carcin... Colon Carcinoma Colorectal Carc... Endometrial Car... Esophageal Carc... Gastric Carcino... Glioma Head and Neck C... Hematopoietic a... Kidney Carcinom... Liver Carcinoma Lung Carcinoma Lymphoma Malignant Uteri... Melanoma Multiple Myelom... Ovarian Carcino... Pancreatic Carc... Prostate Carcin... Rectal Carcinom... Recurrent Bladd... Recurrent Breas... Recurrent Cervi... Recurrent Colon... Recurrent Color... Recurrent Esoph... Recurrent Gastr... Recurrent Gliom... Recurrent Head ... Recurrent Liver... Recurrent Lung ... Recurrent Lymph... Recurrent Malig... Recurrent Melan... Recurrent Multi... Recurrent Ovari... Recurrent Pancr... Recurrent Prost... Recurrent Recta... Recurrent Skin ... Recurrent Thyro... Recurrent Uteri... Refractory Lymp... Refractory Mali... Refractory Mult... Skin Carcinoma Thyroid Gland C... Uterine Corpus ...	Adavosertib Afatinib Afatinib Dimale... Binimetinib Biopsy Biospecimen Col... Capivasertib Computed Tomogr... Copanlisib Copanlisib Hydr... Crizotinib Cytology Specim... Dabrafenib Dabrafenib Mesy... Dasatinib Defactinib Defactinib Hydr... Echocardiograph... Erdafitinib Fexagratinib Ipatasertib Laboratory Biom... Larotrectinib Larotrectinib S... Magnetic Resona... Multigated Acqu... Nivolumab Osimertinib Palbociclib Pertuzumab PI3K-beta Inhib... Radiologic Exam... Radionuclide Im... Relatlimab Sapanisertib Sunitinib Malat... Taselisib Trametinib Trastuzumab Trastuzumab Emt... Ulixertinib Vismodegib	18 Years -	National Cancer Institute (NCI)
Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors	NCT01324635	Recurrent Gliom... High-grade Meni... Brain Metastasi...	Panobinostat Stereotactic bo... Quality-of-life... Stereotactic ra...	18 Years -	Thomas Jefferson University
PARP Inhibition for Gliomas (PI-4G or π4g)	NCT05297864	Recurrent Gliob... Recurrent Astro... Recurrent Oligo... Recurrent Gliom...	Niraparib	18 Years -	University of Oklahoma
Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas	NCT01229644	Glioma	Crenolanib (CP-...	18 Years -	Arog Pharmaceuticals, Inc.
Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma	NCT01011231	Glioblastoma	Gamma Knife Rad...	18 Years -	University of California, San Francisco
Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas	NCT02313272	Malignant Gliom...	Hypofractionate... Pembrolizumab Bevacizumab	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients	NCT02796261	Anaplastic Astr... Recurrent Anapl...	Eflornithine Lomustine Lomustine	18 Years -	Orbus Therapeutics, Inc.
Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma	NCT01478178	Glioma Glioblastoma Glioblastoma Mu... GBM Brain Cancer	VAL-083 (Dianhy...	18 Years -	Kintara Therapeutics, Inc.
Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas	NCT02313272	Malignant Gliom...	Hypofractionate... Pembrolizumab Bevacizumab	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas	NCT02829931	Malignant Gliom...	Hypofractionate... Nivolumab Bevacizumab Ipilimumab	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Amino-acid PET Versus MRI Guided Re-irradiation in Patients With Recurrent Glioblastoma Multiforme	NCT01252459	Recurrent Gliom...	Radiation Thera... Radiation Thera...	18 Years -	University Hospital Freiburg
Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma	NCT00591058	Malignant Gliom... Glioblastoma Mu... GBM Astrocytoma Oligodendroglio...	TM-601	18 Years -	TransMolecular
Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor (Glioblastoma)	NCT03463733	Glioma Glioblastoma	Hydroxyurea Temozolomide	-	Amsterdam UMC, location VUmc
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors	NCT05676489	Healthy Volunte... Recurrent Gliom... Brain Metastase...	[F-18]MeFAMP PE...	18 Months - 89 Years	University of Alabama at Birmingham
Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma	NCT01290692	Grade IV Glioma Grade IV Astroc... Glioblastoma Mu...	TVI-Brain-1	18 Years -	TVAX Biomedical
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors	NCT05676489	Healthy Volunte... Recurrent Gliom... Brain Metastase...	[F-18]MeFAMP PE...	18 Months - 89 Years	University of Alabama at Birmingham
Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma	NCT00591058	Malignant Gliom... Glioblastoma Mu... GBM Astrocytoma Oligodendroglio...	TM-601	18 Years -	TransMolecular
Re-irradiation of High Grade Gliomas: a Quality of Life Study	NCT01711580	Anaplastic Astr... Glioblastoma Mu... Anaplastic Olig...	EORTC QLQ-C30 EORTC QLQ-BN20 Hopkins Verbal ... Stroop color-wo... Controlled oral... Jamar hand dyna... EORTC QLQ- FA13 Trail Making Te...	18 Years -	Maastricht Radiation Oncology
Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting	NCT02717962	Glioma Glioblastoma Glioblastoma Mu... GBM Brain Cancer	VAL-083, Dianhy...	18 Years -	Kintara Therapeutics, Inc.
Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma	NCT01081223	Glioma High Grade Astr... Glioblastoma Mu...	Cancer vaccine ...	18 Years -	TVAX Biomedical
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)	NCT03155620	Advanced Malign... Ann Arbor Stage... Ann Arbor Stage... Histiocytic Sar... Juvenile Xantho... Langerhans Cell... Malignant Gliom... Recurrent Child... Recurrent Epend... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Prima... Recurrent Rhabd... Recurrent Soft ... Refractory Ewin... Refractory Glio... Refractory Hepa... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Medu... Refractory Neur... Refractory Non-... Refractory Oste... Refractory Peri... Refractory Prim... Refractory Rhab... Refractory Rhab... Rhabdoid Tumor Stage III Osteo... Stage III Soft ... Stage IV Osteos... Stage IV Soft T... Stage IVA Osteo... Stage IVB Osteo... Wilms Tumor	Biopsy Biospecimen Col... Bone Marrow Asp... Bone Scan Computed Tomogr... Ensartinib Erdafitinib Laboratory Biom... Larotrectinib S... Magnetic Resona... Mutation Carrie... Olaparib Palbociclib Pharmacological... Positron Emissi... Radionuclide Im... Samotolisib Selpercatinib Selumetinib Sul... Tazemetostat Tipifarnib Ulixertinib Vemurafenib X-Ray Imaging	12 Months - 21 Years	National Cancer Institute (NCI)
PARP Inhibition for Gliomas (PI-4G or π4g)	NCT05297864	Recurrent Gliob... Recurrent Astro... Recurrent Oligo... Recurrent Gliom...	Niraparib	18 Years -	University of Oklahoma
Re-irradiation of High Grade Gliomas: a Quality of Life Study	NCT01711580	Anaplastic Astr... Glioblastoma Mu... Anaplastic Olig...	EORTC QLQ-C30 EORTC QLQ-BN20 Hopkins Verbal ... Stroop color-wo... Controlled oral... Jamar hand dyna... EORTC QLQ- FA13 Trail Making Te...	18 Years -	Maastricht Radiation Oncology
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)	NCT03526250	Advanced Malign... Recurrent Child... Recurrent Ewing... Recurrent Gliom... Recurrent Hepat... Recurrent Kidne... Recurrent Lange... Recurrent Malig... Recurrent Malig... Recurrent Medul... Recurrent Neuro... Recurrent Non-H... Recurrent Osteo... Recurrent Perip... Recurrent Rhabd... Recurrent Rhabd... Recurrent Soft ... Refractory Epen... Refractory Ewin... Refractory Glio... Refractory Hepa... Refractory Lang... Refractory Mali... Refractory Mali... Refractory Medu... Refractory Neur... Refractory Non-... Refractory Oste... Refractory Peri... Refractory Rhab... Refractory Rhab... Refractory Soft...	Laboratory Biom... Palbociclib Pharmacological...	12 Months - 21 Years	National Cancer Institute (NCI)
A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas	NCT04089449	Advanced Solid ... Recurrent Gliom...	PRT811	18 Years -	Prelude Therapeutics

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