Spots Global Cancer Trial Database for Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
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Trial Identification
Brief Title: Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Official Title: A Pilot Trial Testing the Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan in Children and Young Adults With High Grade Glioma (Excluding Diffuse Intrinsic Pontine Glioma)
Study ID: NCT03739372
Interventions
Study Description
Brief Summary: This is a 2 strata pilot trial within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). The study will use a new treatment approach based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. The current study will test the efficacy of such an approach in children with High-grade gliomas HGG.
Detailed Description: For children with High-grade gliomas (HGG) including HGG presenting within the midline structures of the brain and spine, outcome remains poor and the majority of children die from this disease. The current study will use a new treatment approach based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. This treatment strategy has shown promising results in adult patients with solid tumors and is currently being explored in children with DIPG, neuroblastoma and other solid tumors. The current study will test the efficacy of such an approach in children with HGG for which outcomes remain dismal.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of California, San Diego Rady Children's Hospital, San Diego, California, United States
University of California, San Francisco, San Francisco, California, United States
Children's National Medical Center, Washington, District of Columbia, United States
University of Florida, Gainesville, Florida, United States
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
Johns Hopkins University, Baltimore, Maryland, United States
Children's Hospitals and Clinics of Minneapolis, Minneapolis, Minnesota, United States
Washington University, Saint Louis, Missouri, United States
Nationwide Children's Hospital, Columbus, Ohio, United States
The Children's Hospital Of Philadelphia, Philadelphia, Pennsylvania, United States
University of Utah, Salt Lake City, Utah, United States
Seattle Children's Hospital, Seattle, Washington, United States
Contact Details
Name: Sabine Mueller, MD, PhD, MAS
Affiliation: University of California, San Francisco
Role: PRINCIPAL_INVESTIGATOR
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