Spots Global Cancer Trial Database for Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.
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Trial Identification
Brief Title: Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.
Official Title: A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTITUMOR ACTIVITY OF PF-07257876 IN PATIENTS WITH ADVANCED OR METASTATIC TUMORS
Study ID: NCT04881045
Interventions
Study Description
Brief Summary: This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and dose expansion study intended to evaluate the safety, pharmacokinetic, pharmacodynamic and potential clinical benefit of PF-07257876, a CD47-PD-L1 bispecific antibody, in participants with selected advanced or metastatic tumors for whom no standard therapy is available. The study contains 2 parts, single agent Dose Escalation (Part 1) to determine the recommended dose of PF-07257876, followed by Dose Expansion (Part 2) in selected tumor types at the recommended dose.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Mayo Clinic Hospital, Phoenix, Arizona, United States
Mayo Clinic, Scottsdale, Arizona, United States
Highlands Oncology Group, Fayetteville, Arkansas, United States
Highlands Oncology Group, Rogers, Arkansas, United States
Highlands Oncology Group, Springdale, Arkansas, United States
Hoag Hospital Irvine, Irvine, California, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, California, United States
Keck Hospital of USC, Los Angeles, California, United States
Keck School of Medicine of USC, Los Angeles, California, United States
LAC+USC Medical Center, Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
Keck Hospital of USC Pasadena, Pasadena, California, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate (Emergency Back-Up Only), Santa Monica, California, United States
Mayo Clinic Jacksonville, Jacksonville, Florida, United States
Mayo Clinic Rochester, Rochester, Minnesota, United States
Siteman Cancer Center - West County, Creve Coeur, Missouri, United States
Siteman Cancer Center-North County, Florissant, Missouri, United States
Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Washington University, Saint Louis, Missouri, United States
Siteman Cancer Center - South County, Saint Louis, Missouri, United States
Siteman Cancer Center - St Peters, Saint Peters, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States
Duke Cancer Institute, Durham, North Carolina, United States
UPMC Hillman Cancer Center - Camp Hill, Camp Hill, Pennsylvania, United States
UPMC Hillman Cancer Center - Carlisle, Carlisle, Pennsylvania, United States
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania, United States
UPMC Pinnacle - Community Osteopathic / Medical Sciences Pavilion (MSP), Harrisburg, Pennsylvania, United States
UPMC Pinnacle - Ortenzio Cancer Center (OCC), Mechanicsburg, Pennsylvania, United States
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
UPMC Shadyside Hospital, Pittsburgh, Pennsylvania, United States
UPMC Memorial, York, Pennsylvania, United States
Rhode Island Hospital, Providence, Rhode Island, United States
The Miriam Hospital, Providence, Rhode Island, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [barcelona], Spain
Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad DE, Spain
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad DE, Spain
Hospital Clinico de Valencia, Valencia, Valenciana, Comunitat, Spain
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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