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The study will use a dual 1H-31P surface coil pair obtained from IGG Medical Advances, Milwaukee, WI. The coil pair consists of a fixed, 12 cm square 31P resonator co-mounted with a flexible two-loop proton coil. The P.I. and colleagues have used this device for approximately 10 years with no apparent ill effects

Proton-decoupled 31P MRS at 1.5T

The study will use surface coils manufactured by commercial vendors. The pulse sequence programs to be used will be monitored automatically by the scanner to insure that SAR limits are not exceeded.

1H Spectroscopy at 1.5T and 3T

Jason Koutcher, MD, PhD

The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI) except that signals are detected from the chemicals (spectroscopy) naturally present in your body using radio waves. To receive this information from your body, small loops of wire (surface coils), placed near the tissue of interest, may be used to more effectively detect signals that come from the chemicals in your body. The investigators may use a second radio channel simultaneously, which will allow us to obtain greater chemical information (decoupling). The results may also help us to understand how this study can be used to help other patients with your condition.

The investigators propose to use 1H spectroscopy or 1H decoupled 31P NMR spectroscopy to obtain biochemical information about tumor metabolism in patients, both before and after antineoplastic therapy. In healthy volunteers, normal tissue metabolism will also be studied. It is hypothesized that metabolic information may be of prognostic significance, or may be useful for timing of therapy.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Spectroscopy With Surface Coils and Decoupling	NCT00581815	Adrenal Cortica... Brain Cancer Breast Cancer CNS Cancer Colon Cancer HEENT Cancer Hodgkin's Disea... Kaposi's Sarcom... Liver Cancer Lung Cancer Non-Hodgkin's L... Ovarian Cancer Pancreatic Canc... Prostate Cancer Rectal Cancer Renal Cancer Sarcoma Squamous Cell C... Thyroid Cancer	Proton-decouple... 1H Spectroscopy...	18 Years -	Memorial Sloan Kettering Cancer Center
Spectroscopy With Surface Coils and Decoupling	NCT00581815	Adrenal Cortica... Brain Cancer Breast Cancer CNS Cancer Colon Cancer HEENT Cancer Hodgkin's Disea... Kaposi's Sarcom... Liver Cancer Lung Cancer Non-Hodgkin's L... Ovarian Cancer Pancreatic Canc... Prostate Cancer Rectal Cancer Renal Cancer Sarcoma Squamous Cell C... Thyroid Cancer	Proton-decouple... 1H Spectroscopy...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for 1h spectroscopy at 1.5t and 3t