Symptoms and General Pathology

All Conditions

Digestive System Diseases

Neoplasms

Nervous System Diseases

Rare Diseases

Pain, Postoperative

Pain

Fecal Incontinence

Anus Neoplasms

Carcinoma

Carcinoma in Situ

Postoperative Complications

Neurologic Manifestations

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Rectal Diseases

Intestinal Diseases

Gastrointestinal Diseases

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Anus Diseases

Anal Cancer

functional studies before and after anal laser ablation

high resolution anal manometry

Tamzin Cuming, FRCS

Christine Inwang, MSc

Tamzin Cuming, FRCS, MBBS

Mayura Nathan, FRCS

High-grade squamous intraepithelial lesions (HSIL) and anal cancer are rising in incidence and at highest risk are HIV positive men who have sex with men (MSM). This pilot study assessing anal function and patient-reported outcomes before and after laser ablation of HSIL will add to the evidence that such a therapy is an acceptable and safe treatment to offer in a preventative setting.We will be recruting HIV positive and negative MSM.

High resolution anoscopy with targeted laser ablation is one of the therapies currently employed to treat HSIL of the anus to prevent progression to anal cancer. The functional outcome of this procedure has not previously been formally assessed.

HIV and negative positive MSM in whom HSIL has been detected will form the study population, as HSIL is prevalent in these patients and intervention is felt to be indicated. Functional assessments will be carried out prior to initial treatment and then repeated six months after laser ablation therapy. The structure, function and sensitivity of the anal canal will be evaluated using endoanal ultrasound, high-resolution anal manometry and anal mucosal electrosensitivity measurements respectively. Patient-reported outcomes will be assessed using questionnaires and semi-structured interviews at baseline, 4 weeks and 6 months post-treatment.

Function Following Laser for Anal Intraepithelial Neoplasia (FLAN)

Changes in pressure vailues - resting pressure and maximum squeeze pressure compared to patient's own pre treatment values

Changes in sensitivity as measured against patients own pre treatment perception

Changes in endoanal ultrasound abnormalities compared to pre-treatment findings

Qualitative subjective physical and psychological well-being 4 weeks and 6 months after procedure of laser mucosal ablation of AIN

Patient reported outcomes, particularly with regard to sexual function and bowel function

Barts & The London NHS Trust

Homerton University Hospital NHS Foundation Trust

Behaviors and Mental Disorders

Syndrome

Low Anterior Resection Syndrome

Anastomotic Leak

Colonic Diseases

Quality of Life

patients receive coloanal anastomosis operation

patients receive coloanal pull-out anastomosis operation

compare different operational styles of low rectal cancer

Parks technique

Bacon technique

Jun Huang, MD

Jun Huang

The goal of this study is to compare the postoperative anal function of patients with ultra-low rectal cancer after Parks operation (colon anal anastomosis) and Bacon operation (colon anal pull-out anastomosis), which may provide clinical evidence for the improvement of anal function and quality of life.

The main questions it aims to answer are: the difference of anal function 1 year after surgery type of study: clinical trial participant population: patients with low rectal cancer Participants will receive Parks operation of Bacon operation If there is a comparison group: Researchers will compare Parks and Bacon operation to see if the anal function 1 year after surgery is different.

objective: To compare the postoperative anal function of patients with ultra-low rectal cancer after Parks operation (colon anal anastomosis) and Bacon operation (colon anal pull-out anastomosis), which may provide clinical evidence for the improvement of anal function and quality of life.

primary outcome: Low Anterior Resection Syndrome (LARS) score 1 year after surgery secondary outcomes: 1. LARS score at 3 months after surgery 2. LARS score at 6 months after surgery 3. Postoperative Quality of Life Score 4. The incidence of postoperative anastomotic complications

Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer

Comparison of Postoperative Anal Function Between Different Anastomosis Techniques(Parks Versus Bacon) in Low Rectal Cancer: A Prospective, Multicentric and Randomized Controlled Study

use a scoring system for bowel dysfunction after LAR for rectal cancer on the basis of symptoms and impact on quality of life

using a score system to access the quality of life after surgery

the corresponding complications after surgery

Sixth Affiliated Hospital, Sun Yat-sen University

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Urinary Incontinence

Enuresis

Urination Disorders

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Lower Urinary Tract Symptoms

Urological Manifestations

Questionnaire send by post at 3, 6, 12, 18 and 24 months after operation

Structured Rehabilitation program

Rolv-Ole Lindsetmo, MD, Phd, Mph

Quality of life after rectal surgery is reported to be impaired. Side effects of surgery and/or neoadjuvant treatment as functional disturbances like sexual dysfunction, urinary incontinence, anal incontinence or stoma problems are commonly experienced. The investigators hypotheses is that structured rehabilitation program addressing these problems will improve quality of life. A RCT are performed in order to document the effects of the rehabilitation.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Function Following Laser for Anal Intraepithelial Neoplasia (FLAN)	NCT04109573	Anus Cancer Fecal Incontine... Anal Intraepith... Post Operative ...	high resolution...	18 Years -	Homerton University Hospital NHS Foundation Trust
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer	NCT05943444	Rectal Neoplasm... Low Anterior Re... Anastomotic Lea... Quality of Life	Parks technique Bacon technique	18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer	NCT05943444	Rectal Neoplasm... Low Anterior Re... Anastomotic Lea... Quality of Life	Parks technique Bacon technique	18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Effects of Structured Rehabilitation Program on Quality of Life in Rectal Cancer Patients- a Randomized Controlled Trial	NCT00895388	Quality of Life Sexual Function Urinary Inconti... Anal Incontinen...	Structured Reha...	18 Years - 75 Years	University Hospital of North Norway

Spots Global Cancer Trial Database for anal function