Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Esophageal Neoplasms

Ischemia

Constriction, Pathologic

Anastomotic Leak

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Postoperative Complications

Esophageal Cancer

Endoscopic examinations are performed at 1 and 8 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated.

Patients after esophagectomy

Shinichhiro Kobayashi, M.D.

Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

The development and improvement of thoracoscopic esophagectomy (TE) reduced the severe pulmonary complication after esophagectomy. However, the postoperative complications relative to gastric conduit reconstruction are still common issues after esophagectomy. The ischemia of the proximal portion of the graft predisposes these patients to a high incidence of anastomotic complications after esophagectomy. Less commonly, severe graft ischemia can lead to transmural necrosis. Thus, early diagnosis of ischemic reaction may provide the suitable postoperative management and therapeutic intervention to prevent leakage, strictures and necrosis. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy

The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group

Nagasaki University

Principal Investigator in department of Surgery

Endoscopic examinations are performed at 1, 8, and 15 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated.

Shinichiro Kobayashi

Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. However the evaluation and prevention before developing gastric conduit ischemia have been established. The investigators have built a hypothesis that the evaluation for gastric mucosal ischemia in early phase after esophagectomy predict the complication of gastric conduit. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

Endoscopic Evaluation After Esophagectomy

Endoscopic Evaluation for the Postoperative Condition After Esophagectomy and Reconstruction

The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group (J Clin Pathol. 1997 Oct; 50(10): 801-804.)

Assistant professor

Carcinoma

Adenocarcinoma

Cholangiocarcinoma

Biliary Tract Diseases

Bile Duct Diseases

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Bile Duct Cancer

Dermatologic Agents

All Drugs and Chemicals

Antineoplastic Agents

Photosensitizing Agents

Dihematoporphyrin Ether

Trioxsalen

Hematoporphyrin Derivative

Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) would be performed to confirm the position and length of the biliary malignant. A self expanding metallic stent (SEMS) would be placed to bypass the site of narrowing

Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) would be performed to confirm the position and length of the biliary malignant. The radiofrequency ablation (RFA) catheter (EMcision, London, United Kingdom) would be placed under fluoroscopic guidance across the biliary stricture. Radiofrequency energy will be delivered to the malignant site. After that,A self expanding metallic stent (SEMS) would be placed to bypass the site of narrowing

Photofrin is injected 3 days prior to laser activation of the agent.Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) will be carried out to determine the length and positon of the biliary malignant. Delivery Fiber used along with the laser system to activate the photosensitizing agent and induce tumor tissue necrosis. A self expanding metallic stent (SEMS) will be placed the site of biliary narrowing

Self expanding metallic stent (SEMS)

Endoscopic radiofrequency ablation (ERFA)

Photodynamic therapy (PDT)

Huihong Liang, MD

Huihong Liang, Doctorial

Huihong Liang, Doctoral

The purpose of this study is to compare endoscopic radiofrequency ablation with photodynamic therapy for inoperable cholangiocarcinoma

Comparison of Endoscopic Radiofrequency Ablation Versus Photodynamic Therapy for Inoperable Cholangiocarcinoma

A Randomized Controlled Trial Comparing Endoscopic Biliary Radiofrequency Ablation With Photodynamic Therapy for Inoperable Cholangiocarcinoma

Guangzhou Medical University

Associated Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation After Esophagectomy	NCT02703142	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Comparison of Endoscopic Radiofrequency Ablation Versus Photodynamic Therapy for Inoperable Cholangiocarcinoma	NCT01739465	Cholangiocarcin...	Self expanding ... Endoscopic radi... Photodynamic th...	18 Years - 70 Years	Guangzhou Medical University

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