Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Esophageal Neoplasms

Ischemia

Constriction, Pathologic

Anastomotic Leak

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Postoperative Complications

Esophageal Cancer

Endoscopic examinations are performed at 1 and 8 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated.

Patients after esophagectomy

Shinichhiro Kobayashi, M.D.

Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

The development and improvement of thoracoscopic esophagectomy (TE) reduced the severe pulmonary complication after esophagectomy. However, the postoperative complications relative to gastric conduit reconstruction are still common issues after esophagectomy. The ischemia of the proximal portion of the graft predisposes these patients to a high incidence of anastomotic complications after esophagectomy. Less commonly, severe graft ischemia can lead to transmural necrosis. Thus, early diagnosis of ischemic reaction may provide the suitable postoperative management and therapeutic intervention to prevent leakage, strictures and necrosis. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy

The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group

Nagasaki University

Principal Investigator in department of Surgery

Endoscopic examinations are performed at 1, 8, and 15 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated.

Shinichiro Kobayashi

Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. However the evaluation and prevention before developing gastric conduit ischemia have been established. The investigators have built a hypothesis that the evaluation for gastric mucosal ischemia in early phase after esophagectomy predict the complication of gastric conduit. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.

Endoscopic Evaluation After Esophagectomy

Endoscopic Evaluation for the Postoperative Condition After Esophagectomy and Reconstruction

The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group (J Clin Pathol. 1997 Oct; 50(10): 801-804.)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy	NCT02937389	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University
Endoscopic Evaluation After Esophagectomy	NCT02703142	Esophageal Neop... Constriction Anastomotic Lea... Ischemia	Patients after ...	20 Years - 84 Years	Nagasaki University

Spots Global Cancer Trial Database for patients after esophagectomy