Symptoms and General Pathology

All Conditions

Neoplasms

Nervous System Diseases

Heart and Blood Diseases

Wounds and Injuries

Rare Diseases

Hemorrhage

Edema

Brain Neoplasms

Stroke

Hypertension

Intracranial Hypertension

Brain Injuries

Brain Injuries, Traumatic

Cerebral Hemorrhage

Brain Edema

Brain Diseases

Central Nervous System Diseases

Craniocerebral Trauma

Trauma, Nervous System

Cerebrovascular Disorders

Vascular Diseases

Intracranial Hemorrhages

Acute Graft Versus Host Disease

Dynamic decompressive craniotomy with semi-rigid bone flap fixation

Dynamic craniotomy

Prospective observational study on patients undergoing decompressive craniotomy

A prospective study of 20 neurosurgical patients evaluating the dynamic decompressive craniotomy technique using NeuroVention, LLC craniotomy bone flap fixation plates. The plates allow for rigid and semi-rigid bone flap fixation dependent on the implantation technique. A dynamic craniotomy involves bone flap fixation wherein a limited transient outward bone flap movement is allowed by the plates to compensate for an increase in intracranial pressure from brain swelling. The plates also prevent the craniotomy bone flap from sinking inside the skull and compressing on the brain. Cerebral decompression surgery is undertaken for patients with cerebral swelling from malignant strokes, medically intractable intracranial pressure elevation in traumatic brain injuries and brain tumors. The dynamic craniotomy technique eliminates or reduces the need for a cranioplasty surgery with a potentially significant improvement in outcome.

Dynamic Decompressive Craniotomy

Modified Rankin Scale and Glasgow Outcome Score

CT scan to assess rate of normal bone flap position

Halifax Health

Rohit Khanna, MD

Principal Investigator

Recurrence

Glioblastoma

Astrocytoma

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Neuroepithelioma

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Patients will receive best physician's choice chemotherapy along with Optune therapy and craniotomy surgery. Optune therapy will be administered in the standard configuration and in accordance with current guidelines with the exception of the surgical intervention.

For further information see www.optune.com

Optune

A small hole is placed in the skull between the tumor and the closest Optune electrode. The position and geometry of the craniotomy is determined by computersimulation of the electric field induced by Optune therapy. Craniotomy is a surgical procedure, which is carried out under general anaesthesia.

Craniectomy

Anders R Korshoej, MD

The present study proposes a new and potentially superior clinical approach to Optune™ therapy of selected glioblastoma patients. The approach is based on combining TTFields with targeted surgical skull remodeling, such as minor craniectomy or a distribution of burr holes, designed for the individual patient. Pre-clinical modeling results suggest that such procedures may enhance the induced electrical field strength by up to \~100% and thereby potentially improve the clinical outcome of treated patients to a significant extent.

The study is an open label phase 1 clinical pilot experiment designed to investigate feasibility, safety and efficacy of the concept. Fifteen patients with first recurrence of glioblastoma will be included in the trial. All patients will receive TTFields therapy with targeted craniotomy and best physician's choice chemotherapy.

Enhancing Optune Therapy With Targeted Craniectomy

Enhancing Optune Therapy of Recurrent Glioblastoma Multiforme Using Targeted Surgical Skull Remodeling

NovoCure Ltd.

Aarhus University Hospital

Respiratory Tract (Lung and Bronchial) Diseases

Carcinoma, Non-Small-Cell Lung

Neoplasm Metastasis

Lung Neoplasms

Neoplastic Processes

Central Nervous System Neoplasms

Nervous System Neoplasms

craniectomy

The investigators collected the data from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course.

The investigators collected the data from from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course. The investigators use Kaplan-Meier regression to analyze the overall survival, and the difference between the groups was calculated using log rank test. Cox proportional hazards method was used to create the regression model and estimate the hazard ratios.

Genomic Study in Non-small Cell Lung Cancer Brain Metastasis

Genomic Analysis in Surgically Treated NSCLC Brain Metastasis Based on Neurosurgical Perspectives

National Cheng-Kung University Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Dynamic Decompressive Craniotomy	NCT05051488	Brain Edema TBI (Traumatic ... Stroke, Acute Cerebral Hemorr... Brain Tumor	Dynamic craniot... Dynamic craniot...	18 Years -	NeuroVention, LLC
Enhancing Optune Therapy With Targeted Craniectomy	NCT02893137	Glioblastoma	Optune Craniectomy	18 Years -	University of Aarhus
Genomic Study in Non-small Cell Lung Cancer Brain Metastasis	NCT04745715	NSCLC Stage IV Brain Metastase...	craniectomy	-	National Cheng-Kung University Hospital

Spots Global Cancer Trial Database for craniectomy

Every month we try and update this database with for craniectomy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for craniectomy

Every month we try and update this database with for craniectomy cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for craniectomy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.