Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Symptoms and General Pathology

Breast Neoplasms

Carcinoma

Recurrence

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Breast Diseases

Skin Diseases

Patients' archival and newly collected tissue and blood samples are collected periodically for genetic testing. Patients also undergo collection of clinical information within 30 days of biopsy procedure and every 4 months.

Biospecimen Collection

Medical Chart Review

Karthik V. Giridhar, M.D.

This trial collects clinical information and tissue and blood samples from patients with breast cancer that has come back or is stage IV. Collecting clinical information and biospecimen samples to create a registry may help doctors better understand the mechanism of tumor spread and determine why people respond differently to specific cancer treatments.

PRIMARY OBJECTIVES:

I. To create a comprehensive registry that includes patient demographics, clinical and histopathological data, blood samples, and tissue specimens from the primary tumor and metastatic sites of patients with metastatic breast cancer to improve our understanding of the mechanisms of tumor metastasis and therapeutic resistance.

II. To conduct genomic studies of paired primary tumors and distant metastatic sites.

III. To conduct genomic studies of paired distant metastatic sites obtained during the course of an individual's disease.

IV. To conduct genomic studies of cell free deoxyribonucleic acid (DNA), circulating tumor cell (CTC) derived DNA, germline DNA, and immune based markers in the peripheral circulation.

SECONDARY OBJECTIVE:

I. To evaluate the concordance between DNA sequencing results obtained from a clinically available assay and those obtained specifically for research purposes.

OUTLINE:

Patients' archival and newly collected tissue and blood samples are collected periodically for genetic testing. Patients also undergo collection of clinical information within 30 days of biopsy procedure and every 4 months.

Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer

AURORA US: Prospective Biospecimen Repository in Metastatic Breast Cancer

Will create a comprehensive biorepository that includes blood, archival tissue, fresh tissue, and linked molecular and clinical data from patients with recurrent and/or metastatic breast cancer.

Mayo Clinic

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer	NCT03737695	Anatomic Stage ... Invasive Breast... Metastatic Brea... Peritoneal Effu... Recurrent Breas...	Biospecimen Col... Medical Chart R...	18 Years -	Mayo Clinic
Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer	NCT03737695	Anatomic Stage ... Invasive Breast... Metastatic Brea... Peritoneal Effu... Recurrent Breas...	Biospecimen Col... Medical Chart R...	18 Years -	Mayo Clinic

Spots Global Cancer Trial Database for peritoneal effusion