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Spots Global Cancer Trial Database for Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Official Title: A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults

Study ID: NCT02003222

Study Description

Brief Summary: This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.

Detailed Description: PRIMARY OBJECTIVE: I. To compare the overall survival (OS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in patients with BCR-ABL-negative B cell precursor acute lymphoblastic leukemia (ALL) who are minimal residual disease (MRD) negative after induction and intensification chemotherapy, based on multiparameter flow cytometric (MFC) assessment of residual blasts. SECONDARY OBJECTIVES: I. To compare the relapse-free survival (RFS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in MRD negative patients after induction and intensification chemotherapy. II. To compare the OS and RFS of those patients who are MRD positive (+) at step 3 randomization/registration and then convert to MRD negative (-) after 2 cycles of blinatumomab to those patients who are MRD- at randomization and remain MRD- after 2 cycles of blinatumomab or consolidation chemotherapy. III. To assess the toxicities of blinatumomab in this patient population. IV. To assess the toxicities of the modified E2993 chemotherapy regimen in this patient population. V. To describe the outcome of patients who proceed to allogeneic blood or marrow transplant after treatment with or without blinatumomab. LABORATORY OBJECTIVES: I. To determine differences in MRD kinetics among patients with the BCR/ABL1-like B-lineage ALL, and to compare the OS (and RFS) of patients with BCR-ABL-like phenotype with those without BCR-ABL-like phenotype. II. To evaluate the incidence of anti-blinatumomab antibody formation. OUTLINE: INDUCTION CHEMOTHERAPY: Patients receive cytarabine intrathecally (IT) on day 1; daunorubicin hydrochloride intravenously (IV) over 10-15 minutes on days 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone orally (PO) daily on days 1-7 (and 15-21 for patients age \< 55 years only); methotrexate IT on day 14; pegaspargase intramuscularly (IM) or IV on day 18 (patients age \< 55 years); and CD20 positive patients may optionally receive rituximab IV on day 8 and 15. Beginning on day 29, patients with absolute neutrophil count (ANC) \>= 0.75 x 10\^9/L and platelets \> 75 x 10\^9/L (patients with delayed hematologic recovery) (patients with residual disease that is delaying count begin treatment immediately) receive cyclophosphamide IV over 30 minutes on days 1 and 29, cytarabine IV over 30 minutes or subcutaneously (SC) on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14, 29-42, pegaspargase IM or IV on day 15 (patients age \< 55 years), patients receiving treatment for central nervous system (CNS) 2 or 3 leukemia in cycle 1 receive methotrexate IT on days 1, 8, 15, and 22, and CD20 positive patients may optionally receive rituximab IV on days 8 and 15. INTENSIFICATION THERAPY: Beginning 4 weeks after the completion of cycle 2 of induction therapy, patients receive intensification therapy comprising high-dose methotrexate IV over 2 hours on days 1 and 8, and pegaspargase IM or IV on day 9. Patients are then randomized to 1 of 2 treatment arms. Patients randomized to the blinatumomab group receive blinatumomab IV continuously on days 1-28. Treatment repeats every 6 weeks for 2 cycles in the absence of disease progression or unacceptable toxicity. Patients may then undergo allogeneic stem cell transplant (SCT) or proceed to consolidation therapy per investigator discretion. CONSOLIDATION THERAPY: Beginning after the second cycle of blinatumomab (patients randomized to the blinatumomab group) or after intensification therapy (patients not randomized to blinatumomab), patients receive cytarabine IV over 30 minutes or SC on days 1-5, etoposide IV over 1 hour on days 1-5, methotrexate IT on day 1, and pegaspargase IM or IV on day 5, and CD20 positive patients may optionally receive rituximab IV on day 5. Beginning 4 weeks from day 1 of cycle 1, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may receive rituximab as in cycle 1. Beginning 4 weeks from day 1 of cycle 2, patients receive daunorubicin hydrochloride IV over 10-15 minutes on day 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone PO daily on days 1-7 (and 15-21 for patients age \< 55 years); methotrexate IT on day 2; cyclophosphamide IV over 30 minutes on day 29; cytarabine IV over 30 minutes or SC on days 30-33 and 37-40; mercaptopurine PO on days 29-42 and CD20 positive patients may receive rituximab on day 8. Beginning 8 weeks from day 1 of cycle 3, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may optionally receive rituximab as in cycle 1. Patients randomized to blinatumomab repeat cycle 4 and then receive blinatumomab IV continuously on days 1-28. MAINTENANCE THERAPY: Within 6 weeks after beginning last cycle of consolidation therapy, patients receive mercaptopurine PO daily, methotrexate PO or IV over 2 hours once weekly for 2.5 years, vincristine sulfate IV on day 1 every 3 months, prednisone PO on days 1-5 every 3 months, and methotrexate IT on day 1 every 3 months. Treatment continues for up to 2.5 years in the absence of disease progression or unacceptable toxicity. Patients undergo x-ray imaging during screening, lumbar puncture while on study, and bone marrow aspiration, bone marrow biopsy, and blood sample collection throughout the study. After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 5 years.

Keywords

Eligibility

Minimum Age: 30 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

Anchorage Associates in Radiation Medicine, Anchorage, Alaska, United States

Anchorage Radiation Therapy Center, Anchorage, Alaska, United States

Alaska Breast Care and Surgery LLC, Anchorage, Alaska, United States

Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States

Alaska Regional Hospital, Anchorage, Alaska, United States

Alaska Women's Cancer Care, Anchorage, Alaska, United States

Anchorage Oncology Centre, Anchorage, Alaska, United States

Katmai Oncology Group, Anchorage, Alaska, United States

Providence Alaska Medical Center, Anchorage, Alaska, United States

Fairbanks Memorial Hospital, Fairbanks, Alaska, United States

Kingman Regional Medical Center, Kingman, Arizona, United States

Banner University Medical Center - Tucson, Tucson, Arizona, United States

University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States

Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

PCR Oncology, Arroyo Grande, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States

Community Cancer Institute, Clovis, California, United States

University Oncology Associates, Clovis, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States

Stanford Cancer Institute Palo Alto, Palo Alto, California, United States

Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, United States

The Medical Center of Aurora, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States

Cancer Center of Colorado at Sloan's Lake, Denver, Colorado, United States

National Jewish Health-Main Campus, Denver, Colorado, United States

The Women's Imaging Center, Denver, Colorado, United States

Colorado Blood Cancer Institute, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

Rocky Mountain Cancer Centers-Midtown, Denver, Colorado, United States

SCL Health Saint Joseph Hospital, Denver, Colorado, United States

Rocky Mountain Cancer Centers-Rose, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Western Surgical Care, Denver, Colorado, United States

Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

National Jewish Health-Western Hematology Oncology, Golden, Colorado, United States

Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, United States

Grand Valley Oncology, Grand Junction, Colorado, United States

North Colorado Medical Center, Greeley, Colorado, United States

Good Samaritan Medical Center, Lafayette, Colorado, United States

Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, United States

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

National Jewish Health-Northern Hematology Oncology, Thornton, Colorado, United States

SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Yale University, New Haven, Connecticut, United States

Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

UM Sylvester Comprehensive Cancer Center at Coral Springs, Coral Springs, Florida, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

UM Sylvester Comprehensive Cancer Center at Hollywood, Hollywood, Florida, United States

Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States

UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida, United States

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida, United States

Cleveland Clinic-Weston, Weston, Florida, United States

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States

Walter Knox Memorial Hospital, Emmett, Idaho, United States

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho, United States

Idaho Urologic Institute-Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, United States

Kootenai Cancer Clinic, Sandpoint, Idaho, United States

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho, United States

Saint Joseph Medical Center, Bloomington, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Memorial Hospital of Carbondale, Carbondale, Illinois, United States

SIH Cancer Institute, Carterville, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Centralia Oncology Clinic, Centralia, Illinois, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

Northwestern University, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Illinois CancerCare-Dixon, Dixon, Illinois, United States

Crossroads Cancer Center, Effingham, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois, United States

Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois, United States

NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois, United States

Presence Saint Mary's Hospital, Kankakee, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

AMG Libertyville - Oncology, Libertyville, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Illinois Cancer Specialists-Niles, Niles, Illinois, United States

Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Radiation Oncology of Northern Illinois, Ottawa, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Valley Radiation Oncology, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois, United States

North Shore Medical Center, Skokie, Illinois, United States

Central Illinois Hematology Oncology Center, Springfield, Illinois, United States

Southern Illinois University School of Medicine, Springfield, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Southwest Illinois Health Services LLP, Swansea, Illinois, United States

Parkview Hospital Randallia, Fort Wayne, Indiana, United States

Parkview Regional Medical Center, Fort Wayne, Indiana, United States

Franciscan Health Indianapolis, Indianapolis, Indiana, United States

Franciscan Health Mooresville, Mooresville, Indiana, United States

Reid Health, Richmond, Indiana, United States

Mary Greeley Medical Center, Ames, Iowa, United States

McFarland Clinic - Ames, Ames, Iowa, United States

McFarland Clinic - Boone, Boone, Iowa, United States

McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa, United States

McFarland Clinic - Jefferson, Jefferson, Iowa, United States

McFarland Clinic - Marshalltown, Marshalltown, Iowa, United States

Cancer Center of Kansas - Chanute, Chanute, Kansas, United States

Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States

Cancer Center of Kansas - El Dorado, El Dorado, Kansas, United States

Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States

Central Care Cancer Center - Garden City, Garden City, Kansas, United States

Central Care Cancer Center - Great Bend, Great Bend, Kansas, United States

Cancer Center of Kansas-Independence, Independence, Kansas, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Cancer Center of Kansas-Kingman, Kingman, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

Kansas Institute of Medicine Cancer and Blood Center, Lenexa, Kansas, United States

Minimally Invasive Surgery Hospital, Lenexa, Kansas, United States

Cancer Center of Kansas-Liberal, Liberal, Kansas, United States

Cancer Center of Kansas-Manhattan, Manhattan, Kansas, United States

Cancer Center of Kansas - McPherson, McPherson, Kansas, United States

Cancer Center of Kansas - Newton, Newton, Kansas, United States

Olathe Health Cancer Center, Olathe, Kansas, United States

Menorah Medical Center, Overland Park, Kansas, United States

Saint Luke's South Hospital, Overland Park, Kansas, United States

Cancer Center of Kansas - Parsons, Parsons, Kansas, United States

Cancer Center of Kansas - Pratt, Pratt, Kansas, United States

Cancer Center of Kansas - Salina, Salina, Kansas, United States

Cancer Center of Kansas - Wellington, Wellington, Kansas, United States

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas, United States

Associates In Womens Health, Wichita, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, United States

Ascension Via Christi Hospitals Wichita, Wichita, Kansas, United States

Cancer Center of Kansas - Wichita, Wichita, Kansas, United States

Wesley Medical Center, Wichita, Kansas, United States

Cancer Center of Kansas - Winfield, Winfield, Kansas, United States

Oncology Hematology Care Inc-Crestview, Crestview Hills, Kentucky, United States

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States

Ochsner Health Center-Summa, Baton Rouge, Louisiana, United States

Medical Center of Baton Rouge, Baton Rouge, Louisiana, United States

Ochsner High Grove, Baton Rouge, Louisiana, United States

Ochsner LSU Health Monroe Medical Center, Monroe, Louisiana, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States

LSU Health Sciences Center at Shreveport, Shreveport, Louisiana, United States

Eastern Maine Medical Center, Bangor, Maine, United States

Lafayette Family Cancer Center-EMMC, Brewer, Maine, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Bixby Medical Center, Adrian, Michigan, United States

Hickman Cancer Center, Adrian, Michigan, United States

Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

Henry Ford Cancer Institute-Downriver, Brownstown, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Beaumont Hospital - Dearborn, Dearborn, Michigan, United States

Henry Ford Medical Center-Fairlane, Dearborn, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Green Bay Oncology - Escanaba, Escanaba, Michigan, United States

Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States

Beaumont Hospital - Farmington Hills, Farmington Hills, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States

William Beaumont Hospital-Grosse Pointe, Grosse Pointe, Michigan, United States

Allegiance Health, Jackson, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

Sparrow Hospital, Lansing, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

Mercy Memorial Hospital, Monroe, Michigan, United States

Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan, United States

Trinity Health Muskegon Hospital, Muskegon, Michigan, United States

Lakeland Hospital Niles, Niles, Michigan, United States

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan, United States

Henry Ford Medical Center-Columbus, Novi, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

Huron Medical Center PC, Port Huron, Michigan, United States

Lake Huron Medical Center, Port Huron, Michigan, United States

Spectrum Health Reed City Hospital, Reed City, Michigan, United States

Michigan Cancer Specialists, Roseville, Michigan, United States

Oakland Colon Rectal Associates, Royal Oak, Michigan, United States

Cancer Care Associates PC, Royal Oak, Michigan, United States

Comprehensive Medical Center PLLC, Royal Oak, Michigan, United States

Hematology Oncology Consultants PC, Royal Oak, Michigan, United States

Oakland Medical Group, Royal Oak, Michigan, United States

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Lakeland Medical Center Saint Joseph, Saint Joseph, Michigan, United States

Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Premier Hematology Oncology Care, Sterling Heights, Michigan, United States

Mitchell Folbe MD PC, Sterling Heights, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

Michigan Institute of Urology-Town Center, Troy, Michigan, United States

Claudia BR Herke MD PC, Troy, Michigan, United States

William Beaumont Hospital - Troy, Troy, Michigan, United States

Hematology Oncology Consultants PC-Troy, Troy, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan, United States

University of Michigan Health - West, Wyoming, Michigan, United States

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri, United States

Central Care Cancer Center - Bolivar, Bolivar, Missouri, United States

Parkland Health Center-Bonne Terre, Bonne Terre, Missouri, United States

Cox Cancer Center Branson, Branson, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Southeast Cancer Center, Cape Girardeau, Missouri, United States

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, United States

Parkland Health Center - Farmington, Farmington, Missouri, United States

Centerpoint Medical Center LLC, Independence, Missouri, United States

Capital Region Southwest Campus, Jefferson City, Missouri, United States

Freeman Health System, Joplin, Missouri, United States

Mercy Hospital Joplin, Joplin, Missouri, United States

Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States

Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States

Liberty Radiation Oncology Center, Liberty, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States

Heartland Regional Medical Center, Saint Joseph, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Mercy Hospital South, Saint Louis, Missouri, United States

Siteman Cancer Center-South County, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri, United States

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Missouri Baptist Sullivan Hospital, Sullivan, Missouri, United States

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri, United States

Mercy Hospital Washington, Washington, Missouri, United States

Community Hospital of Anaconda, Anaconda, Montana, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Saint Vincent Healthcare, Billings, Montana, United States

Saint Vincent Frontier Cancer Center, Billings, Montana, United States

Bozeman Deaconess Hospital, Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Saint Peter's Community Hospital, Helena, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Community Medical Hospital, Missoula, Montana, United States

Nebraska Medicine-Bellevue, Bellevue, Nebraska, United States

Nebraska Medicine-Village Pointe, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Carson Tahoe Regional Medical Center, Carson City, Nevada, United States

Cancer and Blood Specialists-Henderson, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson, Nevada, United States

Las Vegas Cancer Center-Henderson, Henderson, Nevada, United States

OptumCare Cancer Care at Seven Hills, Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson, Nevada, United States

GenesisCare USA - Henderson, Henderson, Nevada, United States

Las Vegas Urology - Green Valley, Henderson, Nevada, United States

Las Vegas Urology - Pebble, Henderson, Nevada, United States

Urology Specialists of Nevada - Green Valley, Henderson, Nevada, United States

Las Vegas Urology - Pecos, Las Vegas, Nevada, United States

Desert West Surgery, Las Vegas, Nevada, United States

OptumCare Cancer Care at Charleston, Las Vegas, Nevada, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Hope Cancer Care of Nevada, Las Vegas, Nevada, United States

Cancer and Blood Specialists-Shadow, Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Central, Las Vegas, Nevada, United States

GenesisCare USA - Las Vegas, Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas, Nevada, United States

Sunrise Hospital and Medical Center, Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas, Nevada, United States

Las Vegas Prostate Cancer Center, Las Vegas, Nevada, United States

Las Vegas Urology - Sunset, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Southwest, Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada, United States

Cancer Therapy and Integrative Medicine, Las Vegas, Nevada, United States

Ann M Wierman MD LTD, Las Vegas, Nevada, United States

Cancer and Blood Specialists-Tenaya, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, United States

GenesisCare USA - Vegas Tenaya, Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas, Nevada, United States

Las Vegas Urology - Cathedral Rock, Las Vegas, Nevada, United States

Las Vegas Urology - Smoke Ranch, Las Vegas, Nevada, United States

OptumCare Cancer Care at MountainView, Las Vegas, Nevada, United States

Urology Specialists of Nevada - Northwest, Las Vegas, Nevada, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada, United States

Summerlin Hospital Medical Center, Las Vegas, Nevada, United States

Las Vegas Cancer Center-Medical Center, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

GenesisCare USA - Fort Apache, Las Vegas, Nevada, United States

OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas, Nevada, United States

University Cancer Center, Las Vegas, Nevada, United States

Hope Cancer Care of Nevada-Pahrump, Pahrump, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Saint Mary's Regional Medical Center, Reno, Nevada, United States

Radiation Oncology Associates, Reno, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Montefiore Medical Center-Einstein Campus, Bronx, New York, United States

Montefiore Medical Center-Weiler Hospital, Bronx, New York, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Memorial Sloan Kettering Commack, Commack, New York, United States

Memorial Sloan Kettering Westchester, Harrison, New York, United States

Northwell Health/Center for Advanced Medicine, Lake Success, New York, United States

North Shore University Hospital, Manhasset, New York, United States

Long Island Jewish Medical Center, New Hyde Park, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

University of Rochester, Rochester, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

Memorial Sloan Kettering Nassau, Uniondale, New York, United States

AdventHealth Infusion Center Asheville, Asheville, North Carolina, United States

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States

AdventHealth Infusion Center Haywood, Clyde, North Carolina, United States

AdventHealth Hendersonville, Hendersonville, North Carolina, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Indu and Raj Soin Medical Center, Beavercreek, Ohio, United States

Saint Elizabeth Boardman Hospital, Boardman, Ohio, United States

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green, Ohio, United States

Dayton Physicians LLC-Miami Valley South, Centerville, Ohio, United States

Miami Valley Hospital South, Centerville, Ohio, United States

Oncology Hematology Care Inc-Eden Park, Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Mercy West, Cincinnati, Ohio, United States

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Anderson, Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Blue Ash, Cincinnati, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Good Samaritan Hospital - Dayton, Dayton, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Dayton Physician LLC-Miami Valley Hospital North, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Oncology Hematology Care Inc-Healthplex, Fairfield, Ohio, United States

Armes Family Cancer Center, Findlay, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Orion Cancer Care, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Dayton Physicians LLC-Atrium, Franklin, Ohio, United States

Dayton Physicians LLC-Wayne, Greenville, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Greater Dayton Cancer Center, Kettering, Ohio, United States

First Dayton Cancer Care, Kettering, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Lima Memorial Hospital, Lima, Ohio, United States

Toledo Clinic Cancer Centers-Maumee, Maumee, Ohio, United States

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee, Ohio, United States

Dayton Physicians LLC-Signal Point, Middletown, Ohio, United States

Saint Charles Hospital, Oregon, Ohio, United States

Toledo Clinic Cancer Centers-Oregon, Oregon, Ohio, United States

Dayton Physicians LLC-Wilson, Sidney, Ohio, United States

Springfield Regional Cancer Center, Springfield, Ohio, United States

Springfield Regional Medical Center, Springfield, Ohio, United States

ProMedica Flower Hospital, Sylvania, Ohio, United States

Mercy Hospital of Tiffin, Tiffin, Ohio, United States

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio, United States

Saint Vincent Mercy Medical Center, Toledo, Ohio, United States

University of Toledo, Toledo, Ohio, United States

Toledo Community Hospital Oncology Program CCOP, Toledo, Ohio, United States

Mercy Health - Saint Anne Hospital, Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States

Dayton Physicians LLC - Troy, Troy, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Saint Joseph Warren Hospital, Warren, Ohio, United States

Fulton County Health Center, Wauseon, Ohio, United States

University of Cincinnati Cancer Center-West Chester, West Chester, Ohio, United States

Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio, United States

Saint Elizabeth Youngstown Hospital, Youngstown, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, United States

Saint Alphonsus Medical Center-Baker City, Baker City, Oregon, United States

Saint Charles Health System, Bend, Oregon, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States

Bay Area Hospital, Coos Bay, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Saint Alphonsus Medical Center-Ontario, Ontario, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Saint Charles Health System-Redmond, Redmond, Oregon, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania, United States

Community Medical Center, Scranton, Pennsylvania, United States

AnMed Health Cancer Center, Anderson, South Carolina, United States

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, United States

Prisma Health Cancer Institute - Easley, Easley, South Carolina, United States

Gibbs Cancer Center-Gaffney, Gaffney, South Carolina, United States

Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Butternut, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States

Prisma Health Greenville Memorial Hospital, Greenville, South Carolina, United States

Saint Francis Cancer Center, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States

Gibbs Cancer Center-Pelham, Greer, South Carolina, United States

Carolina Blood and Cancer Care Associates PA-Lancaster, Lancaster, South Carolina, United States

Carolina Blood and Cancer Care Associates PA, Rock Hill, South Carolina, United States

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States

Spartanburg Medical Center, Spartanburg, South Carolina, United States

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin, Tennessee, United States

Vanderbilt Breast Center at One Hundred Oaks, Nashville, Tennessee, United States

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

Parkland Memorial Hospital, Dallas, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

Ben Taub General Hospital, Houston, Texas, United States

Houston Methodist Hospital, Houston, Texas, United States

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah, United States

Sandra L Maxwell Cancer Center, Cedar City, Utah, United States

Farmington Health Center, Farmington, Utah, United States

Logan Regional Hospital, Logan, Utah, United States

Intermountain Medical Center, Murray, Utah, United States

McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center, Provo, Utah, United States

Riverton Hospital, Riverton, Utah, United States

Saint George Regional Medical Center, Saint George, Utah, United States

Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

South Jordan Health Center, South Jordan, Utah, United States

Fredericksburg Oncology Inc, Fredericksburg, Virginia, United States

VCU Massey Cancer Center at Stony Point, Richmond, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Providence Regional Cancer System-Aberdeen, Aberdeen, Washington, United States

Cancer Care Center at Island Hospital, Anacortes, Washington, United States

MultiCare Auburn Medical Center, Auburn, Washington, United States

Overlake Medical Center, Bellevue, Washington, United States

Swedish Cancer Institute-Eastside Oncology Hematology, Bellevue, Washington, United States

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Swedish Cancer Institute-Edmonds, Edmonds, Washington, United States

Providence Regional Cancer Partnership, Everett, Washington, United States

MultiCare Gig Harbor Medical Park, Gig Harbor, Washington, United States

Swedish Cancer Institute-Issaquah, Issaquah, Washington, United States

Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States

Providence Regional Cancer System-Lacey, Lacey, Washington, United States

PeaceHealth Saint John Medical Center, Longview, Washington, United States

Jefferson Healthcare, Port Townsend, Washington, United States

MultiCare Good Samaritan Hospital, Puyallup, Washington, United States

Valley Medical Center, Renton, Washington, United States

Minor and James Medical PLLC, Seattle, Washington, United States

Pacific Gynecology Specialists, Seattle, Washington, United States

Swedish Medical Center-Ballard Campus, Seattle, Washington, United States

Kaiser Permanente Washington, Seattle, Washington, United States

Swedish Medical Center-Cherry Hill, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

PeaceHealth United General Medical Center, Sedro-Woolley, Washington, United States

Providence Regional Cancer System-Shelton, Shelton, Washington, United States

MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley, Washington, United States

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane, Washington, United States

Evergreen Hematology and Oncology PS, Spokane, Washington, United States

MultiCare Deaconess Cancer and Blood Specialty Center - North, Spokane, Washington, United States

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington, United States

MultiCare Tacoma General Hospital, Tacoma, Washington, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington, United States

Providence Regional Cancer System-Yelm, Yelm, Washington, United States

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire, Wisconsin, United States

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States

Holy Family Memorial Hospital, Manitowoc, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Marinette, Marinette, Wisconsin, United States

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States

Marshfield Medical Center, Marshfield, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin, United States

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, United States

HSHS Saint Nicholas Hospital, Sheboygan, Wisconsin, United States

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Marshfield Clinic-Wausau Center, Wausau, Wisconsin, United States

Marshfield Medical Center - Weston, Weston, Wisconsin, United States

Rocky Mountain Oncology, Casper, Wyoming, United States

Cheyenne Regional Medical Center-West, Cheyenne, Wyoming, United States

Big Horn Basin Cancer Center, Cody, Wyoming, United States

Billings Clinic-Cody, Cody, Wyoming, United States

Welch Cancer Center, Sheridan, Wyoming, United States

Tom Baker Cancer Centre, Calgary, Alberta, Canada

Clinical Research Unit at Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax, Nova Scotia, Canada

Kingston Health Sciences Centre, Kingston, Ontario, Canada

CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Rambam Medical Center, Haifa, , Israel

Shaare Zedek Medical Center, Jerusalem, , Israel

Cancer Center-Metro Medical Center Bayamon, Bayamon, , Puerto Rico

Doctors Cancer Center, Manati, , Puerto Rico

San Juan Community Oncology Group, San Juan, , Puerto Rico

Centro Comprensivo de Cancer de UPR, San Juan, , Puerto Rico

San Juan City Hospital, San Juan, , Puerto Rico

Contact Details

Name: Mark R Litzow

Affiliation: ECOG-ACRIN Cancer Research Group

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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