Spots Global Cancer Trial Database for lumbar puncture

Every month we try and update this database with for lumbar puncture cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)	NCT06210750	T Acute Lymphob... T Lymphoblastic...	Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Calaspargase Pe... Computed Tomogr... Cyclophosphamid... Cytarabine Daunorubicin Dexamethasone Doxorubicin Echocardiograph... Lumbar Puncture Mercaptopurine Methotrexate Multigated Acqu... Navitoclax Nelarabine Pegaspargase Positron Emissi... Thioguanine Venetoclax Vincristine X-Ray Imaging	18 Years - 60 Years	National Cancer Institute (NCI)
Randomized Evaluation of a Positioning Pillow for Lumbar Puncture in Paediatric Hematology-Oncology	NCT00775112	Spinal Puncture	pillow	2 Years - 18 Years	Centre Leon Berard
NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma	NCT05359211	Recurrent Diffu... Recurrent Diffu... Recurrent Grade... Recurrent Prima... Refractory Diff... Refractory Diff... Refractory Grad... Refractory Prim... Transformed Ind...	Cyclophosphamid... Fludarabine Lisocabtagene M... Polymer-conjuga... X-Ray Imaging Echocardiograph... Multigated Acqu... Bone Marrow Bio... Bone Marrow Asp... Lumbar Puncture Computed Tomogr... Positron Emissi... Biospecimen Col... Biopsy	18 Years -	Fred Hutchinson Cancer Center
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia	NCT02981628	Recurrent B Acu... Recurrent B Lym... Refractory B Ac... Refractory B Ly...	Asparaginase Er... Biospecimen Col... Bone Marrow Asp... Calaspargase Pe... Cyclophosphamid... Cytarabine Diagnostic Imag... Inotuzumab Ozog... Leucovorin Calc... Lumbar Puncture Methotrexate Pegaspargase Vincristine	1 Year - 21 Years	Children's Oncology Group
A Study of SNDX-5613 in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia	NCT05761171	Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Mixed... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Mixe...	Biospecimen Col... Bone Marrow Asp... Calaspargase Pe... Cytarabine Echocardiograph... Fludarabine Pho... Hydrocortisone ... Lumbar Puncture Methotrexate Multigated Acqu... Prednisolone Prednisone Revumenib Vincristine Sul...	1 Month - 6 Years	Children's Oncology Group
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease	NCT03025256	Acral Lentigino... Central Nervous... Clinical Stage ... Leptomeningeal ... Melanocytoma Metastatic Lung... Metastatic Mela... Metastatic Muco... Metastatic Uvea... Stage IV Lung C...	Biospecimen Col... Computed Tomogr... Lumbar Puncture Magnetic Resona... Nivolumab Positron Emissi...	18 Years -	M.D. Anderson Cancer Center
Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell Therapy	NCT05936229	Recurrent B Acu... Recurrent B-Cel... Refractory B Ac... Refractory B-Ce... Recurrent Mantl... Refractory Mant...	Interferon Beta... X-Ray Imaging Echocardiograph... Multigated Acqu... Computed Tomogr... Positron Emissi... Lumbar Puncture Bone Marrow Asp... Bone Marrow Bio... Biospecimen Col... Biopsy	18 Years -	Fred Hutchinson Cancer Center
Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer	NCT05130840	Breast Cancer	MRI Lumbar puncture	18 Years -	Memorial Sloan Kettering Cancer Center
Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma	NCT05910801	Recurrent Mantl... Refractory Mant...	Biopsy Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Computed Tomogr... Lenalidomide Lumbar Puncture Magnetic Resona... Positron Emissi... Tafasitamab Venetoclax	18 Years -	Academic and Community Cancer Research United
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma	NCT04609046	Primary Diffuse...	Bone Marrow Asp... Computed Tomogr... Echocardiograph... Lenalidomide Lumbar Puncture Magnetic Resona... Methotrexate Nivolumab Positron Emissi... Rituximab Ultrasound Imag...	18 Years -	National Cancer Institute (NCI)
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System	NCT01596127	Leukemia Lymphoid Malign... Metastatic Mali...	Intrathecal Rit...	3 Years -	M.D. Anderson Cancer Center
Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children	NCT00405522	Spinal Puncture	Propofol 2.0 mg... Propofol 4.0 mg...	3 Years - 12 Years	The Hospital for Sick Children
Diagnosis; Objective RespOnse; THErApy	NCT05036564	Primary CNS Lym...	Lumbar puncture	18 Years -	IRCCS San Raffaele
Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia	NCT04872790	B Acute Lymphob... B Acute Lymphob... Mixed Phenotype... Recurrent B Acu... Recurrent Mixed...	Dasatinib Methotrexate Prednisone Rituximab Venetoclax Blinatumomab Bone Marrow Asp... Lumbar Puncture Biospecimen Col...	18 Years -	OHSU Knight Cancer Institute
Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy	NCT04359784	B-Cell Non-Hodg...	Anakinra X-Ray Imaging Positron Emissi... Computed Tomogr... Bone Marrow Asp... Bone Marrow Bio... Lumbar Puncture Biospecimen Col...	18 Years -	Fred Hutchinson Cancer Center
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia	NCT02003222	Acute Lymphobla... B Acute Lymphob...	Allogeneic Hema... Biospecimen Col... Blinatumomab Bone Marrow Asp... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Etoposide Lumbar Puncture Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Vincristine Sul... X-Ray Imaging	30 Years - 70 Years	National Cancer Institute (NCI)
Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer	NCT05130840	Breast Cancer	MRI Lumbar puncture	18 Years -	Memorial Sloan Kettering Cancer Center
NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma	NCT05359211	Recurrent Diffu... Recurrent Diffu... Recurrent Grade... Recurrent Prima... Refractory Diff... Refractory Diff... Refractory Grad... Refractory Prim... Transformed Ind...	Cyclophosphamid... Fludarabine Lisocabtagene M... Polymer-conjuga... X-Ray Imaging Echocardiograph... Multigated Acqu... Bone Marrow Bio... Bone Marrow Asp... Lumbar Puncture Computed Tomogr... Positron Emissi... Biospecimen Col... Biopsy	18 Years -	Fred Hutchinson Cancer Center
Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast Cancer	NCT05746325	Anatomic Stage ... Metastatic Brea... Metastatic Mali...	Digital Photogr... Lumbar Puncture Magnetic Resona... Medical Device ...	18 Years -	Mayo Clinic
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control	NCT04796935	Central Nervous... Pseudotumor Cer... Neurological Di... Cancer Obstetric Proce... Orthopedic Proc... Post-Dural Punc...	Tactile Imaging... Control (palpat...	18 Years -	IntuiTap Medical, Inc
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia	NCT02003222	Acute Lymphobla... B Acute Lymphob...	Allogeneic Hema... Biospecimen Col... Blinatumomab Bone Marrow Asp... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Etoposide Lumbar Puncture Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Vincristine Sul... X-Ray Imaging	30 Years - 70 Years	National Cancer Institute (NCI)
Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children	NCT00405522	Spinal Puncture	Propofol 2.0 mg... Propofol 4.0 mg...	3 Years - 12 Years	The Hospital for Sick Children
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma	NCT04609046	Primary Diffuse...	Bone Marrow Asp... Computed Tomogr... Echocardiograph... Lenalidomide Lumbar Puncture Magnetic Resona... Methotrexate Nivolumab Positron Emissi... Rituximab Ultrasound Imag...	18 Years -	National Cancer Institute (NCI)
Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome	NCT05457556	Acute Lymphobla... Acute Myeloid L... Mixed Phenotype... Myelodysplastic...	Biospecimen Col... Bone Marrow Asp... Busulfan Cyclophosphamid... Echocardiograph... Fludarabine Haploidentical ... Lapine T-Lympho... Lumbar Puncture Matched Unrelat... Melphalan Methotrexate Multigated Acqu... Mycophenolate M... Myeloablative C... Quality-of-Life... Questionnaire A... Rituximab T-Cell Depletio... Tacrolimus Thiotepa Total-Body Irra...	6 Months - 21 Years	Children's Oncology Group
Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced Cancer	NCT02580045	Metastatic Canc... Advanced Cancer Brain Metastasi...		18 Years -	Duke University
Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults	NCT04530565	B Acute Lymphob...	Biospecimen Col... Blinatumomab Bone Marrow Asp... Cyclophosphamid... Cytarabine Dasatinib Dexamethasone Doxorubicin Hyd... Echocardiograph... Electrocardiogr... Lumbar Puncture Mesna Methotrexate Multigated Acqu... Ponatinib Hydro... Prednisone Vincristine Sul...	18 Years - 75 Years	National Cancer Institute (NCI)
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control	NCT04796935	Central Nervous... Pseudotumor Cer... Neurological Di... Cancer Obstetric Proce... Orthopedic Proc... Post-Dural Punc...	Tactile Imaging... Control (palpat...	18 Years -	IntuiTap Medical, Inc
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases	NCT01713699	Meningeal Carci...	lumbar puncture	18 Years -	The Netherlands Cancer Institute
Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast Cancer	NCT05746325	Anatomic Stage ... Metastatic Brea... Metastatic Mali...	Digital Photogr... Lumbar Puncture Magnetic Resona... Medical Device ...	18 Years -	Mayo Clinic
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma	NCT06368817	Central Nervous... Diabetes Insipi... Pineal Region G... Suprasellar Ger...	3-Dimensional C... Biospecimen Col... Carboplatin Etoposide Intensity-Modul... Lumbar Puncture Magnetic Resona... Questionnaire A... Surgical Proced...	3 Years - 30 Years	Children's Oncology Group
Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell Therapy	NCT05936229	Recurrent B Acu... Recurrent B-Cel... Refractory B Ac... Refractory B-Ce... Recurrent Mantl... Refractory Mant...	Interferon Beta... X-Ray Imaging Echocardiograph... Multigated Acqu... Computed Tomogr... Positron Emissi... Lumbar Puncture Bone Marrow Asp... Bone Marrow Bio... Biospecimen Col... Biopsy	18 Years -	Fred Hutchinson Cancer Center
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma	NCT06368817	Central Nervous... Diabetes Insipi... Pineal Region G... Suprasellar Ger...	3-Dimensional C... Biospecimen Col... Carboplatin Etoposide Intensity-Modul... Lumbar Puncture Magnetic Resona... Questionnaire A... Surgical Proced...	3 Years - 30 Years	Children's Oncology Group
A Study of SNDX-5613 in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia	NCT05761171	Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Acute... Recurrent Mixed... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Acut... Refractory Mixe...	Biospecimen Col... Bone Marrow Asp... Calaspargase Pe... Cytarabine Echocardiograph... Fludarabine Pho... Hydrocortisone ... Lumbar Puncture Methotrexate Multigated Acqu... Prednisolone Prednisone Revumenib Vincristine Sul...	1 Month - 6 Years	Children's Oncology Group
Video/Audio Distraction Analgesia for Simulated Oncology Procedure Pain	NCT00701571	Pain	Virtual Reality...	18 Years -	University of Washington
Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia	NCT04872790	B Acute Lymphob... B Acute Lymphob... Mixed Phenotype... Recurrent B Acu... Recurrent Mixed...	Dasatinib Methotrexate Prednisone Rituximab Venetoclax Blinatumomab Bone Marrow Asp... Lumbar Puncture Biospecimen Col...	18 Years -	OHSU Knight Cancer Institute
Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes) for the Treatment of Primary Central Nervous System Lymphoma	NCT05625594	Central Nervous...	Aspiration Biospecimen Col... Catheterization CD19CAR-CD28-CD... Computed Tomogr... Cyclophosphamid... Fludarabine Leukapheresis Lumbar Puncture Magnetic Resona... Positron Emissi...	18 Years -	City of Hope Medical Center
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control	NCT04796935	Central Nervous... Pseudotumor Cer... Neurological Di... Cancer Obstetric Proce... Orthopedic Proc... Post-Dural Punc...	Tactile Imaging... Control (palpat...	18 Years -	IntuiTap Medical, Inc
Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer	NCT02598427	HER2 Positive U... Asymptomatic or...	Pertuzumab Trastuzumab	18 Years -	Duke University
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma	NCT04609046	Primary Diffuse...	Bone Marrow Asp... Computed Tomogr... Echocardiograph... Lenalidomide Lumbar Puncture Magnetic Resona... Methotrexate Nivolumab Positron Emissi... Rituximab Ultrasound Imag...	18 Years -	National Cancer Institute (NCI)
Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer	NCT05130840	Breast Cancer	MRI Lumbar puncture	18 Years -	Memorial Sloan Kettering Cancer Center
Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma	NCT05910801	Recurrent Mantl... Refractory Mant...	Biopsy Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Computed Tomogr... Lenalidomide Lumbar Puncture Magnetic Resona... Positron Emissi... Tafasitamab Venetoclax	18 Years -	Academic and Community Cancer Research United
Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer	NCT02598427	HER2 Positive U... Asymptomatic or...	Pertuzumab Trastuzumab	18 Years -	Duke University
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases	NCT01713699	Meningeal Carci...	lumbar puncture	18 Years -	The Netherlands Cancer Institute
Diagnosis; Objective RespOnse; THErApy	NCT05036564	Primary CNS Lym...	Lumbar puncture	18 Years -	IRCCS San Raffaele
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma	NCT03919071	Anaplastic Astr... Anaplastic Astr... Anaplastic Gang... Anaplastic Pleo... Glioblastoma Malignant Gliom... WHO Grade 3 Gli...	Biospecimen Col... Dabrafenib Mesy... Lumbar Puncture Magnetic Resona... Radiation Thera... Trametinib Dime...	12 Months - 21 Years	National Cancer Institute (NCI)
Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma	NCT05910801	Recurrent Mantl... Refractory Mant...	Biopsy Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Computed Tomogr... Lenalidomide Lumbar Puncture Magnetic Resona... Positron Emissi... Tafasitamab Venetoclax	18 Years -	Academic and Community Cancer Research United
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia	NCT02003222	Acute Lymphobla... B Acute Lymphob...	Allogeneic Hema... Biospecimen Col... Blinatumomab Bone Marrow Asp... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Etoposide Lumbar Puncture Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Vincristine Sul... X-Ray Imaging	30 Years - 70 Years	National Cancer Institute (NCI)

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