Spots Global Cancer Trial Database for pegaspargase

Every month we try and update this database with for pegaspargase cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)	NCT06210750	T Acute Lymphob... T Lymphoblastic...	Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Calaspargase Pe... Computed Tomogr... Cyclophosphamid... Cytarabine Daunorubicin Dexamethasone Doxorubicin Echocardiograph... Lumbar Puncture Mercaptopurine Methotrexate Multigated Acqu... Navitoclax Nelarabine Pegaspargase Positron Emissi... Thioguanine Venetoclax Vincristine X-Ray Imaging	18 Years - 60 Years	National Cancer Institute (NCI)
Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia	NCT00002785	Leukemia	filgrastim asparaginase cyclophosphamid... cyclosporine cytarabine daunorubicin hy... dexamethasone etoposide leucovorin calc... mercaptopurine mesna methotrexate methylprednisol... pegaspargase prednisone therapeutic hyd... vincristine sul... allogeneic bone... low-LET cobalt-... low-LET photon ...	- 1 Year	Children's Oncology Group
Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia	NCT00049569	L1 Childhood Ac... L2 Childhood Ac... Non-T, Non-B Ch... Recurrent Child... T-cell Childhoo...	cytarabine methotrexate vincristine sul... prednisone pegaspargase doxorubicin hyd... imatinib mesyla... cyclophosphamid... etoposide filgrastim leucovorin calc... asparaginase therapeutic hyd...	1 Year - 21 Years	National Cancer Institute (NCI)
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma	NCT00408005	T Acute Lymphob... T Lymphoblastic...	Asparaginase Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Nelarabine Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 30 Years	National Cancer Institute (NCI)
Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia	NCT00381680	B-cell Childhoo... L1 Childhood Ac... L2 Childhood Ac... Intermediate Ri...	vincristine sul... prednisone doxorubicin hyd... pegaspargase cytarabine methotrexate dexamethasone etoposide cyclophosphamid... leucovorin calc... filgrastim asparaginase mercaptopurine	1 Year - 29 Years	Children's Oncology Group
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia	NCT02981628	Recurrent B Acu... Recurrent B Lym... Refractory B Ac... Refractory B Ly...	Asparaginase Er... Biospecimen Col... Bone Marrow Asp... Calaspargase Pe... Cyclophosphamid... Cytarabine Diagnostic Imag... Inotuzumab Ozog... Leucovorin Calc... Lumbar Puncture Methotrexate Pegaspargase Vincristine	1 Year - 21 Years	Children's Oncology Group
Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia	NCT02101853	Recurrent B Acu...	Allogeneic Hema... Asparaginase Blinatumomab Cyclophosphamid... Cytarabine Dexamethasone Etoposide Leucovorin Calc... Mercaptopurine Methotrexate Mitoxantrone Mitoxantrone Hy... Pegaspargase Pharmacological... Radiation Thera... Therapeutic Hyd... Thioguanine Vincristine Vincristine Sul...	1 Year - 31 Years	National Cancer Institute (NCI)
Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00002744	Leukemia	asparaginase cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate pegaspargase prednisone therapeutic hyd... thioguanine vincristine sul... low-LET cobalt-... low-LET photon ...	1 Year - 9 Years	Children's Oncology Group
Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL	NCT03564704	Leukemia Leukemia, Acute Adult Lymphobla... Leukemia, Lymph... Leukemia, T Cel... Adult Acute Lym... Lymphoblastic L... Lymphoblastic L...	Dexamethasone vincristine Cyclophosphamid... Idarubicin Pegaspargase Adriamycin Methotrexate 6-mercaptopurin... Etoposide Cytarabine Bone marrow asp... Intrathecal inj... Radiation thera... NGS allogeneic hema... Flow-MRD FISH Flow immunophen... Karyotyping Chidamide PET-CT scan	14 Years - 55 Years	Nanfang Hospital, Southern Medical University
L-DEP Regimen as a Salvage Therapy for Refractory Epstein Barr Virus-induced Hemophagocytic Lymphohistiocytosis	NCT02631109	Hemophagocytic ...	Pegaspargase doxorubicin etoposide methylprednisol...	14 Years - 75 Years	Beijing Friendship Hospital
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia	NCT00550992	Leukemia	anti-thymocyte ... asparaginase busulfan cyclophosphamid... cyclosporine cytarabine daunorubicin hy... etoposide leucovorin calc... melphalan mercaptopurine methotrexate mitoxantrone hy... pegaspargase prednisolone prednisone therapeutic hyd... thioguanine vincristine sul... allogeneic bone... allogeneic hema... umbilical cord ...	- 1 Year	Dutch Childhood Oncology Group
Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma	NCT01700946	Recurrent B-Cel... Recurrent Child...	dexamethasone vincristine sul... rituximab clofarabine cyclophosphamid... etoposide aldesleukin pegaspargase methotrexate mercaptopurine cytarabine mitoxantrone teniposide vinblastine natural killer ... laboratory biom... therapeutic hyd... allogeneic hema... CliniMACS	- 21 Years	St. Jude Children's Research Hospital
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations	NCT02883049	B Acute Lymphob... B Acute Lymphob... Central Nervous... Testicular Leuk...	Clofarabine Cyclophosphamid... Cytarabine Dasatinib Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Etoposide Hydrocortisone ... Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 31 Years	National Cancer Institute (NCI)
Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage	NCT00890656	Acute Lymphobla...	Cyclophosphamid... Vincristine Doxorubicin Decadron G-CSF Methotrexate (M... Ara-C Pegaspargase	-	M.D. Anderson Cancer Center
Dose Individualization of Antineoplastic Drugs and Anti-Infective Drug in Children With Hematoplastic Disease	NCT03844360	Hematological N...	Bortezomib Eltrombopag Imatinib dasatinib Pegaspargase Anti-Infective ... PEGylated Recom...	1 Day - 18 Years	Shandong University
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma	NCT00408005	T Acute Lymphob... T Lymphoblastic...	Asparaginase Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Nelarabine Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 30 Years	National Cancer Institute (NCI)
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma	NCT01190930	Acute Lymphobla... Adult B Lymphob... Ann Arbor Stage... Ann Arbor Stage... Childhood B Acu... Childhood B Acu... Childhood B Lym... Down Syndrome Hypodiploid B A... Philadelphia Ch...	Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Hyd... Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Quality-of-Life... Questionnaire A... Thioguanine Vincristine Sul...	1 Year - 30 Years	Children's Oncology Group
Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00002744	Leukemia	asparaginase cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate pegaspargase prednisone therapeutic hyd... thioguanine vincristine sul... low-LET cobalt-... low-LET photon ...	1 Year - 9 Years	Children's Oncology Group
Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)	NCT03792256	Leukemia, Lymph... Lymphoblastic L... T-cell Lymphoma T-cell Leukemia Recurrent Disea... Acute Leukemia	Palbociclib Cytarabine Methotrexate Hydrocortisone Doxorubicin Prednisolone Vincristine Pegaspargase Hydrocortisone Prednisone	12 Months - 31 Years	Children's Oncology Group
Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer	NCT01313078	Ovarian Neoplas... Fallopian Tube ... Primary Periton...	Pegylated L-Asp...	18 Years -	National Institutes of Health Clinical Center (CC)
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations	NCT02883049	B Acute Lymphob... B Acute Lymphob... Central Nervous... Testicular Leuk...	Clofarabine Cyclophosphamid... Cytarabine Dasatinib Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Etoposide Hydrocortisone ... Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 31 Years	National Cancer Institute (NCI)
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia	NCT00022737	Childhood Acute... Recurrent Child...	filgrastim asparaginase cyclophosphamid... cyclosporine cytarabine daunorubicin hy... dexamethasone etoposide ifosfamide imatinib mesyla... leucovorin calc... mercaptopurine ... methotrexate pegaspargase vincristine sul... allogeneic bone... peripheral bloo... umbilical cord ... radiation thera...	1 Year - 21 Years	National Cancer Institute (NCI)
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia	NCT02003222	Acute Lymphobla... B Acute Lymphob...	Allogeneic Hema... Biospecimen Col... Blinatumomab Bone Marrow Asp... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Etoposide Lumbar Puncture Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Vincristine Sul... X-Ray Imaging	30 Years - 70 Years	National Cancer Institute (NCI)
Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia	NCT00967057	Leukemia	asparaginase dexamethasone idarubicin methotrexate mitoxantrone hy... pegaspargase vincristine sul...	1 Year - 18 Years	National Cancer Institute (NCI)
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma	NCT03117751	Acute Lymphobla... Acute Lymphobla...	Prednisone Vincristine Daunorubicin Pegaspargase Erwinase® Cyclophosphamid... Cytarabine Mercaptopurine Dasatinib Methotrexate Blinatumomab Ruxolitinib Bortezomib Dexamethasone Doxorubicin Etoposide Clofarabine Vorinostat Idarubicin Nelarabine Thioguanine Asparaginase Er... Calaspargase Pe...	1 Year - 18 Years	St. Jude Children's Research Hospital
Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00557193	Acute Lymphobla... Acute Undiffere... Childhood T Acu...	Asparaginase Biospecimen Col... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Echocardiograph... Etoposide Filgrastim Laboratory Biom... Lestaurtinib Leucovorin Calc... Mercaptopurine Methotrexate Methylprednisol... Multigated Acqu... Pegaspargase Pharmacological... Prednisone Therapeutic Hyd... Vincristine Sul...	- 1 Year	Children's Oncology Group
PEG-ASP+Gemoxd vs. PEG-ASP+CHOP as First-line Chemotherapy to Treatment NK/T-cell Lymphoma With Early Stage	NCT02918747	Lymphoma	pegaspargase Gemcitabine Oxaliplatin Dexamethasone Cyclophosphamid... Doxorubicin Vincristine Prednisone IMRT	18 Years - 70 Years	Hunan Cancer Hospital
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes	NCT00096135	Leukemia	filgrastim cyclophosphamid... cytarabine daunorubicin hy... dexamethasone etoposide leucovorin calc... mercaptopurine methotrexate pegaspargase therapeutic hyd... vincristine sul... radiation thera...	18 Months - 29 Years	Children's Oncology Group
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia	NCT03914625	B Acute Lymphob... B Lymphoblastic... Down Syndrome	Asparaginase Er... Blinatumomab Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Mercaptopurine ... Methotrexate Pegaspargase Prednisolone Prednisone Radiation Thera... Radiation Thera... Thioguanine Vincristine Sul...	365 Days - 31 Years	National Cancer Institute (NCI)
Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL	NCT02660762	Leukaemia,Lymph...	Vincristine Daunorubicin Pegaspargase Prednisone Intrathecal Met... Cyclophosphamid... Cytarabine 6-Mercaptopurin... Methotrexate Etoposide dexamethasone thioguanine intrathecal cyt...	18 Years - 35 Years	Sun Yat-sen University
Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia	NCT00002812	Leukemia	asparaginase cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... idarubicin mercaptopurine methotrexate pegaspargase prednisone thioguanine vincristine sul... radiation thera...	1 Year - 21 Years	Children's Oncology Group
Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia	NCT00022126	Leukemia	asparaginase cyclophosphamid... cyclosporine cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate methylprednisol... pegaspargase thioguanine vincristine sul... allogeneic bone... radiation thera...	- 1 Year	Children's Oncology Group
Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)	NCT00098839	Recurrent Child...	L-asparaginase doxorubicin hyd... therapeutic hyd... vincristine sul... epratuzumab cytarabine prednisone pegaspargase dexrazoxane hyd... methotrexate etoposide cyclophosphamid... leucovorin calc... filgrastim	2 Years - 31 Years	Children's Oncology Group
Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia	NCT05660473	Precursor Cell ...	Vincristine Daunorubicin Cyclophosphamid... Pegaspargase Prednisone Cytarabine 6-mercaptopurin... Dexamethasone Methotrexate Venetoclax	14 Years - 60 Years	Institute of Hematology & Blood Diseases Hospital, China
PEG-ASP+Gemoxd vs. PEG-ASP+CHOP as First-line Chemotherapy to Treatment NK/T-cell Lymphoma With Early Stage	NCT02918747	Lymphoma	pegaspargase Gemcitabine Oxaliplatin Dexamethasone Cyclophosphamid... Doxorubicin Vincristine Prednisone IMRT	18 Years - 70 Years	Hunan Cancer Hospital
A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL)	NCT06124157	B Acute Lymphob...	Biospecimen Col... Blinatumomab Bone Marrow Bio... Calaspargase Pe... Cyclophosphamid... Cytarabine Dasatinib Daunorubicin Doxorubicin Echocardiograph... Leucovorin Mercaptopurine Methotrexate Multigated Acqu... Pegaspargase Prednisolone Prednisone Radiation Thera... Thioguanine Vincristine	366 Days - 46 Years	National Cancer Institute (NCI)
Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement	NCT02828358	Acute Leukemia ... B Acute Lymphob... Mixed Phenotype...	Azacitidine Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Hydrocortisone ... Laboratory Biom... Leucovorin Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Pharmacological... Prednisolone Thioguanine Vincristine Vincristine Sul...	- 364 Days	National Cancer Institute (NCI)
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia	NCT02003222	Acute Lymphobla... B Acute Lymphob...	Allogeneic Hema... Biospecimen Col... Blinatumomab Bone Marrow Asp... Bone Marrow Bio... Cyclophosphamid... Cytarabine Daunorubicin Daunorubicin Hy... Dexamethasone Etoposide Lumbar Puncture Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Vincristine Sul... X-Ray Imaging	30 Years - 70 Years	National Cancer Institute (NCI)
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes	NCT00096135	Leukemia	filgrastim cyclophosphamid... cytarabine daunorubicin hy... dexamethasone etoposide leucovorin calc... mercaptopurine methotrexate pegaspargase therapeutic hyd... vincristine sul... radiation thera...	18 Months - 29 Years	Children's Oncology Group
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL	NCT01483690	Acute Lymphobla... Precursor B-Cel... Precursor T-Cel...	Decitabine Vorinostat Vincristine Dexamethasone Mitoxantrone Pegaspargase Methotrexate	1 Year - 21 Years	Therapeutic Advances in Childhood Leukemia Consortium
Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young Adults	NCT02535806	Acute Lymphobla... Lymphoblastic L...	Velcade Methotrexate Methotrexate / ... Dexamethasone Mitoxantrone Vincristine Pegaspargase	1 Year - 39 Years	Children's Mercy Hospital Kansas City
Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma	NCT00873093	B-cell Adult Ac... B-cell Childhoo... Recurrent Adult... Recurrent Adult... Recurrent Child... Recurrent Child... T-cell Adult Ac... T-cell Childhoo...	L-asparaginase doxorubicin hyd... therapeutic hyd... vincristine sul... cytarabine prednisone bortezomib pegaspargase methotrexate etoposide phosp... cyclophosphamid... filgrastim leucovorin calc... laboratory biom... High Dose MTX	1 Year - 31 Years	National Cancer Institute (NCI)
Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia	NCT00381680	B-cell Childhoo... L1 Childhood Ac... L2 Childhood Ac... Intermediate Ri...	vincristine sul... prednisone doxorubicin hyd... pegaspargase cytarabine methotrexate dexamethasone etoposide cyclophosphamid... leucovorin calc... filgrastim asparaginase mercaptopurine	1 Year - 29 Years	Children's Oncology Group
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia	NCT03914625	B Acute Lymphob... B Lymphoblastic... Down Syndrome	Asparaginase Er... Blinatumomab Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Mercaptopurine ... Methotrexate Pegaspargase Prednisolone Prednisone Radiation Thera... Radiation Thera... Thioguanine Vincristine Sul...	365 Days - 31 Years	National Cancer Institute (NCI)
Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia	NCT03318419	Acute Lymphobla...	Cladribine G-CSF Cytarabine Pegaspargase	18 Years - 80 Years	Sun Yat-sen University
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma	NCT01403415	Childhood B Acu... Childhood T Acu... Mature T-Cell a... Recurrent Child... Recurrent Child...	Dexamethasone Laboratory Biom... Methotrexate Mitoxantrone Hy... Pegaspargase Pharmacological... Temsirolimus Vincristine Sul...	1 Year - 21 Years	National Cancer Institute (NCI)
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents	NCT03020030	Acute Lymphobla...	Pegaspargase Erwinia asparag... Cyclophosphamid... CYTARABINE DASATINIB DEXAMETHASONE Dexrazoxane Doxorubicin ETOPOSIDE HYDROCORTISONE LEUCOVORIN CALC... MERCAPTOPURINE METHOTREXATE NELARABINE Vincristine	1 Year - 21 Years	Dana-Farber Cancer Institute
Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL	NCT03553238	Leukemia, Acute Leukemia, T Cel... Leukemia, Lymph...	Chidamide Dexamethasone vincristine Cyclophosphamid... Idarubicin Pegaspargase Adriamycin Methotrexate 6-Mercaptopurin... Etoposide Cytarabine Bone marrow asp... Intrathecal inj... Radiation thera... NGS allogeneic hema... Flow-MRD FISH Flow immunophen... Karyotyping	14 Years - 55 Years	Nanfang Hospital, Southern Medical University
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia	NCT00075725	Acute Lymphobla... Adult B Acute L... Childhood B Acu...	Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 30 Years	Children's Oncology Group
Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL	NCT03553238	Leukemia, Acute Leukemia, T Cel... Leukemia, Lymph...	Chidamide Dexamethasone vincristine Cyclophosphamid... Idarubicin Pegaspargase Adriamycin Methotrexate 6-Mercaptopurin... Etoposide Cytarabine Bone marrow asp... Intrathecal inj... Radiation thera... NGS allogeneic hema... Flow-MRD FISH Flow immunophen... Karyotyping	14 Years - 55 Years	Nanfang Hospital, Southern Medical University
Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia	NCT00882206	Leukemia Lymphoma	cytarabine decitabine doxorubicin hyd... imatinib mesyla... methotrexate pegaspargase prednisone vincristine sul... vorinostat	2 Years - 60 Years	Masonic Cancer Center, University of Minnesota
Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00720109	Acute Lymphobla... Adult B Acute L... Childhood B Acu...	Asparaginase Cyclophosphamid... Cytarabine Dasatinib Daunorubicin Hy... Dexamethasone Etoposide Filgrastim Hydrocortisone ... Ifosfamide Laboratory Biom... Leucovorin Calc... Mercaptopurine Methotrexate Methylprednisol... Pegaspargase Prednisone Radiation Thera... Vincristine Sul...	2 Years - 30 Years	National Cancer Institute (NCI)
Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT01005758	Leukemia	cyclophosphamid... cytarabine dexamethasone doxorubicin hyd... etoposide phosp... hydrocortisone ... imatinib mesyla... mercaptopurine methotrexate methylprednisol... pegaspargase prednisolone prednisone vincristine sul... laboratory biom... radiation thera...	18 Years - 50 Years	National Cancer Institute (NCI)
Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)	NCT00866307	Acute Lymphobla... Adult B Acute L... Childhood B Acu...	Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Laboratory Biom... Mercaptopurine Methotrexate Pegaspargase Prednisone Prophylactic Cr... Thioguanine Vincristine Sul...	1 Year - 30 Years	Children's Oncology Group
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia	NCT00075725	Acute Lymphobla... Adult B Acute L... Childhood B Acu...	Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 30 Years	Children's Oncology Group
Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia	NCT00003437	Leukemia	asparaginase cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate pegaspargase prednisolone thioguanine vincristine sul... radiation thera...	1 Year - 18 Years	National Cancer Institute (NCI)
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017	NCT03643276	Acute Lymphobla...	Blinatumomab Bortezomib Cyclophosphamid... Cytarabine Daunorubicin Myocet Dexamethasone Doxorubicin Etoposide Fludarabine Pho... Ifosfamide 6-Mercaptopurin... Methotrexate Pegaspargase Prednisolone Tioguanin Vincristine Vindesine Erwinase	- 17 Years	University Hospital Schleswig-Holstein
Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma	NCT00873093	B-cell Adult Ac... B-cell Childhoo... Recurrent Adult... Recurrent Adult... Recurrent Child... Recurrent Child... T-cell Adult Ac... T-cell Childhoo...	L-asparaginase doxorubicin hyd... therapeutic hyd... vincristine sul... cytarabine prednisone bortezomib pegaspargase methotrexate etoposide phosp... cyclophosphamid... filgrastim leucovorin calc... laboratory biom... High Dose MTX	1 Year - 31 Years	National Cancer Institute (NCI)
Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia	NCT03318419	Acute Lymphobla...	Cladribine G-CSF Cytarabine Pegaspargase	18 Years - 80 Years	Sun Yat-sen University
Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia	NCT02101853	Recurrent B Acu...	Allogeneic Hema... Asparaginase Blinatumomab Cyclophosphamid... Cytarabine Dexamethasone Etoposide Leucovorin Calc... Mercaptopurine Methotrexate Mitoxantrone Mitoxantrone Hy... Pegaspargase Pharmacological... Radiation Thera... Therapeutic Hyd... Thioguanine Vincristine Vincristine Sul...	1 Year - 31 Years	National Cancer Institute (NCI)
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy	NCT03959085	B Acute Lymphob... B Lymphoblastic... Central Nervous... Mixed Phenotype... Testicular Leuk...	Biospecimen Col... Bone Marrow Asp... Bone Marrow Bio... Bone Scan Calaspargase Pe... Computed Tomogr... Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Inotuzumab Ozog... Leucovorin Calc... Magnetic Resona... Mercaptopurine Methotrexate Pegaspargase Positron Emissi... Prednisolone Questionnaire A... Radiation Thera... Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 25 Years	Children's Oncology Group
Combination Chemotherapy in Treating Children With Lymphoma	NCT00002590	Lymphoma	filgrastim cyclophosphamid... cytarabine daunorubicin hy... doxorubicin hyd... etoposide leucovorin calc... methotrexate pegaspargase prednisone thioguanine vincristine sul... radiation thera...	- 20 Years	Children's Oncology Group
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)	NCT04546399	Down Syndrome Recurrent B Acu...	3-Dimensional C... Blinatumomab Cyclophosphamid... Cytarabine Dexamethasone Etoposide Hydrocortisone ... Leucovorin Calc... Mercaptopurine Methotrexate Nivolumab Pegaspargase Thioguanine Vincristine Sul...	1 Year - 30 Years	National Cancer Institute (NCI)
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL	NCT01483690	Acute Lymphobla... Precursor B-Cel... Precursor T-Cel...	Decitabine Vorinostat Vincristine Dexamethasone Mitoxantrone Pegaspargase Methotrexate	1 Year - 21 Years	Therapeutic Advances in Childhood Leukemia Consortium
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00558519	Leukemia	cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate pegaspargase thioguanine vincristine sul... radiation thera...	16 Years - 39 Years	Alliance for Clinical Trials in Oncology
Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma	NCT00002766	Leukemia Lymphoma	dactinomycin sargramostim carmustine cyclophosphamid... cytarabine daunorubicin hy... doxorubicin hyd... etoposide mercaptopurine methotrexate mitoxantrone hy... pegaspargase prednisone vincristine sul... radiation thera...	18 Years - 120 Years	Memorial Sloan Kettering Cancer Center
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents	NCT03020030	Acute Lymphobla...	Pegaspargase Erwinia asparag... Cyclophosphamid... CYTARABINE DASATINIB DEXAMETHASONE Dexrazoxane Doxorubicin ETOPOSIDE HYDROCORTISONE LEUCOVORIN CALC... MERCAPTOPURINE METHOTREXATE NELARABINE Vincristine	1 Year - 21 Years	Dana-Farber Cancer Institute
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes	NCT00096135	Leukemia	filgrastim cyclophosphamid... cytarabine daunorubicin hy... dexamethasone etoposide leucovorin calc... mercaptopurine methotrexate pegaspargase therapeutic hyd... vincristine sul... radiation thera...	18 Months - 29 Years	Children's Oncology Group
Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Patients With Relapsed/Refractory B-cell ALL	NCT03962465	B-cell Acute Ly...	Inotuzumab ozog... Prednisone Pill Daunorubicin Vincristine Cytarabine Methotrexate Pegaspargase	16 Years - 60 Years	University of Virginia
Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT01005758	Leukemia	cyclophosphamid... cytarabine dexamethasone doxorubicin hyd... etoposide phosp... hydrocortisone ... imatinib mesyla... mercaptopurine methotrexate methylprednisol... pegaspargase prednisolone prednisone vincristine sul... laboratory biom... radiation thera...	18 Years - 50 Years	National Cancer Institute (NCI)
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	NCT00103285	Acute Lymphobla... Childhood B Acu...	3-Dimensional C... Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Thioguanine Vincristine Sul...	1 Year - 9 Years	Children's Oncology Group
Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma	NCT00501826	T Acute Lymphob... T Lymphoblastic...	Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Hyd... Mercaptopurine Methotrexate Nelarabine Pegaspargase Prednisone Venetoclax Vincristine Sul...	-	M.D. Anderson Cancer Center
Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax	NCT05192889	Refractory Acut... Relapsed Acute ...	Venetoclax Navitoclax Dexamethasone Vincristine Calaspargase Pe... Dasatinib Cytarabine Blinatumomab Methotrexate Mercaptopurine Cyclophosphamid... Etoposide Leucovorin Intrathecal Tri... Pegaspargase Erwinia asparag... Radiation	4 Years - 30 Years	St. Jude Children's Research Hospital
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia	NCT02723994	Leukemia	Ruxolitinib Asparaginase Er... Cyclophosphamid... Cytarabine Dexamethasone Doxorubicin Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Thioguanine Vincristine Sul...	1 Year - 21 Years	Incyte Corporation
Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia	NCT00381680	B-cell Childhoo... L1 Childhood Ac... L2 Childhood Ac... Intermediate Ri...	vincristine sul... prednisone doxorubicin hyd... pegaspargase cytarabine methotrexate dexamethasone etoposide cyclophosphamid... leucovorin calc... filgrastim asparaginase mercaptopurine	1 Year - 29 Years	Children's Oncology Group
Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia	NCT05157971	B Acute Lymphob... Ph-Like Acute L...	Cyclophosphamid... Cytarabine Daunorubicin Hy... Mercaptopurine Methotrexate Pegaspargase Prednisone Venetoclax Vincristine Sul...	18 Years - 54 Years	City of Hope Medical Center
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia	NCT00075725	Acute Lymphobla... Adult B Acute L... Childhood B Acu...	Cyclophosphamid... Cytarabine Daunorubicin Hy... Dexamethasone Doxorubicin Hyd... Leucovorin Calc... Mercaptopurine Methotrexate Pegaspargase Prednisone Radiation Thera... Thioguanine Vincristine Sul...	1 Year - 30 Years	Children's Oncology Group
Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia	NCT00005945	Leukemia	cyclophosphamid... cytarabine daunorubicin hy... dexamethasone doxorubicin hyd... mercaptopurine methotrexate pegaspargase thioguanine vincristine sul... radiation thera...	1 Year - 9 Years	Children's Oncology Group
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia	NCT00550992	Leukemia	anti-thymocyte ... asparaginase busulfan cyclophosphamid... cyclosporine cytarabine daunorubicin hy... etoposide leucovorin calc... melphalan mercaptopurine methotrexate mitoxantrone hy... pegaspargase prednisolone prednisone therapeutic hyd... thioguanine vincristine sul... allogeneic bone... allogeneic hema... umbilical cord ...	- 1 Year	Dutch Childhood Oncology Group
Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax	NCT05192889	Refractory Acut... Relapsed Acute ...	Venetoclax Navitoclax Dexamethasone Vincristine Calaspargase Pe... Dasatinib Cytarabine Blinatumomab Methotrexate Mercaptopurine Cyclophosphamid... Etoposide Leucovorin Intrathecal Tri... Pegaspargase Erwinia asparag... Radiation	4 Years - 30 Years	St. Jude Children's Research Hospital

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