Spots Global Cancer Trial Database for tuberous sclerosis
Every month we try and update this database with for tuberous sclerosis cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1) | NCT00789828 | Tuberous Sclero... Subependymal Gi... | Everolimus Placebo | - | Novartis | |
| Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery | NCT04344626 | Epilepsy Focal Cortical ... Tuberous Sclero... Hemimegalenceph... Polymicrogyria Rasmussen Encep... Sturge-Weber Sy... Gliosis Stroke Tumor, Brain | Intra-operative... | - | University of California, Los Angeles | |
| Turmeric as Treatment in Epilepsy | NCT03254680 | Epilepsy Dravet Syndrome Lennox-Gastaut ... Tuberous Sclero... Focal Seizures | Turmeric | 1 Year - 70 Years | NYU Langone Health | |
| Phase III Trial of Topical Formulation of Sirolimus to Skin Lesions in Patients With Tuberous Sclerosis Complex (TSC) | NCT02635789 | Tuberous Sclero... Angiofibroma Hypomelanotic M... Plaque | NPC-12G gel Placebo gel | 3 Years - | Nobelpharma | |
| Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) | NCT00790400 | Tuberous Sclero... Lymphangioleiom... | Everolimus (RAD... Everolimus Plac... | 18 Years - | Novartis | |
| Clinical Trial Data Set Re-use With Statistical Methodologies Tailored for Clinical Trials in Rare Diseases | NCT05199402 | Tuberous Sclero... Epilepsy | 4 Months - 2 Years | Imagine Institute | ||
| Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex | NCT00411619 | Tuberous Sclero... Subependymal Gi... | Everolimus | 3 Years - | Children's Hospital Medical Center, Cincinnati | |
| A Study of Everolimus in the Treatment of Neurocognitive Problems in Tuberous Sclerosis | NCT01954693 | Tuberous Sclero... | Placebo Everolimus (RAD... | 16 Years - 60 Years | Cardiff University | |
| Studies of Autistic Patients: Gene Networks and Clinical Subtypes | NCT01092208 | Autism Tuberous Sclero... | 4 Years - 18 Years | National Institutes of Health Clinical Center (CC) | ||
| Study of Skin Tumors in Tuberous Sclerosis | NCT00001975 | Tuberous Sclero... | 18 Years - 90 Years | National Institutes of Health Clinical Center (CC) | ||
| Topical Rapamycin to Erase Angiofibromas in TSC | NCT01526356 | Angiofibromas Tuberous Sclero... | Placebo Rapamycin Rapamycin | - | The University of Texas Health Science Center, Houston | |
| Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients | NCT01266291 | Complex Partial... | vigabatrin | 18 Years - | University of Pennsylvania | |
| JASPER Early Intervention for Tuberous Sclerosis | NCT03422367 | Tuberous Sclero... | JASPER | 6 Months - 40 Months | University of California, Los Angeles | |
| Remote Assessment and Intervention for Behavior Problems in Kids With TSC | NCT06311474 | Tuberous Sclero... | Parent-Child In... | 3 Years - 6 Years | University of California, Los Angeles | |
| Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling | NCT06330350 | Quality of Life Ichthyosis Palmoplantar Ke... Epidermolysis B... Ectodermal Dysp... Basal Cell Nevu... Birt-Hogg-Dube ... Tuberous Sclero... Cutis Laxa Albinism | Qualitative int... | - | Maastricht University Medical Center | |
| Turmeric as Treatment in Epilepsy | NCT03254680 | Epilepsy Dravet Syndrome Lennox-Gastaut ... Tuberous Sclero... Focal Seizures | Turmeric | 1 Year - 70 Years | NYU Langone Health | |
| Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM | NCT00490789 | Tuberous Sclero... Lymphangioleiom... | sirolimus | 18 Years - 65 Years | Cardiff University | |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders | NCT06081348 | Neurodevelopmen... Autism Autism Spectrum... Fragile X Syndr... Tuberous Sclero... 22Q11 Deletion ... 22Q11 Deletion ADHD Tic Disorders Tourette Syndro... Tourette Syndro... Tourette Syndro... ADHD - Combined... ADHD Predominan... ADHD, Predomina... Provisional Tic... Anxiety Anxiety Disorde... Agoraphobia Generalized Anx... Generalized Anx... Social Anxiety Social Anxiety ... Unspecified Anx... Other Specified... Separation Anxi... | Sertraline Placebo | 8 Years - 17 Years | Anagnostou, Evdokia, M.D. | |
| Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma | NCT02325505 | Tuberous Sclero... Lymphangioleiom... Angiomyolipoma | - | InCor Heart Institute | ||
| TSC Biosample Repository and Natural History Database | NCT05676099 | Tuberous Sclero... Lymphangioleiom... | Phlebotomy Buccal (cheek) ... Genetic Testing Tissue donation... | - | National Tuberous Sclerosis Association | |
| Parent and Infant Inter(X)Action Intervention (PIXI) | NCT03836300 | Fragile X Syndr... Angelman Syndro... Prader-Willi Sy... Dup15Q Syndrome Duchenne Muscul... Phelan-McDermid... Rett Syndrome Smith Magenis S... Williams Syndro... Turner Syndrome Klinefelter Syn... Chromosome 22q1... Tuberous Sclero... Down Syndrome | Parent-Infant I... | - 99 Years | RTI International | |
| Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM | NCT00490789 | Tuberous Sclero... Lymphangioleiom... | sirolimus | 18 Years - 65 Years | Cardiff University | |
| Study of the Disease Process of Lymphangioleiomyomatosis | NCT00001465 | Lung Disease Pneumothorax Tuberous Sclero... Lymphangioleiom... | Toshibia Aquili... | 16 Years - 100 Years | National Institutes of Health Clinical Center (CC) | |
| RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMAS | NCT00126672 | Nonmalignant Ne... Tuberous Sclero... Lymphangioleimy... Kidney Angiomyo... | Rapamycin | 3 Years - 65 Years | Dana-Farber Cancer Institute | |
| Study of Skin Tumors in Tuberous Sclerosis | NCT00001975 | Tuberous Sclero... | 18 Years - 90 Years | National Institutes of Health Clinical Center (CC) | ||
| Role of Genetic Factors in the Development of Lung Disease | NCT00001532 | Cystic Fibrosis Pulmonary Fibro... Tuberous Sclero... Asthma Pulmonary Sarco... | 2 Years - 90 Years | National Institutes of Health Clinical Center (CC) | ||
| Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients | NCT01266291 | Complex Partial... | vigabatrin | 18 Years - | University of Pennsylvania | |
| RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMAS | NCT00126672 | Nonmalignant Ne... Tuberous Sclero... Lymphangioleimy... Kidney Angiomyo... | Rapamycin | 3 Years - 65 Years | Dana-Farber Cancer Institute | |
| A Study of Everolimus in the Treatment of Neurocognitive Problems in Tuberous Sclerosis | NCT01954693 | Tuberous Sclero... | Placebo Everolimus (RAD... | 16 Years - 60 Years | Cardiff University | |
| Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling | NCT06330350 | Quality of Life Ichthyosis Palmoplantar Ke... Epidermolysis B... Ectodermal Dysp... Basal Cell Nevu... Birt-Hogg-Dube ... Tuberous Sclero... Cutis Laxa Albinism | Qualitative int... | - | Maastricht University Medical Center | |
| Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex | NCT03826628 | Facial Angiofib... Tuberous Sclero... | rapamycin placebo | 6 Years - 65 Years | Dermatology Specialties Limited Partnership | |
| Reproductive Options in Inherited Skin Diseases | NCT06330324 | Ichthyosis Palmoplantar Ke... Epidermolysis B... Ectodermal Dysp... Basal Cell Nevu... Birt-Hogg-Dube ... Tuberous Sclero... Xeroderma Pigme... Cutis Laxa Albinism | - | Maastricht University Medical Center | ||
| Turmeric as Treatment in Epilepsy | NCT03254680 | Epilepsy Dravet Syndrome Lennox-Gastaut ... Tuberous Sclero... Focal Seizures | Turmeric | 1 Year - 70 Years | NYU Langone Health | |
| JASPER Early Intervention for Tuberous Sclerosis | NCT03422367 | Tuberous Sclero... | JASPER | 6 Months - 40 Months | University of California, Los Angeles | |
| Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers | NCT02104011 | Renal Angiomyol... Tuberous Sclero... | Propranolol | 18 Years - | University Hospital, Bordeaux | |
| Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM) | NCT00792766 | Tuberous Sclero... Angiolipoma | everolimus (RAD... | 18 Years - 65 Years | Children's Hospital Medical Center, Cincinnati | |
| Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies | NCT02890641 | Refractory Foca... Focal Cortical ... Hemimegalenceph... Tuberous Sclero... Mild Malformati... | Sampling of blo... | 3 Months - 25 Years | Fondation Ophtalmologique Adolphe de Rothschild | |
| Gait in Rare Diseases | NCT05161494 | Tuberous Sclero... STXBP1 Encephal... | 6 Years - 25 Years | Universiteit Antwerpen | ||
| Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery | NCT04344626 | Epilepsy Focal Cortical ... Tuberous Sclero... Hemimegalenceph... Polymicrogyria Rasmussen Encep... Sturge-Weber Sy... Gliosis Stroke Tumor, Brain | Intra-operative... | - | University of California, Los Angeles | |
| Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex | NCT00411619 | Tuberous Sclero... Subependymal Gi... | Everolimus | 3 Years - | Children's Hospital Medical Center, Cincinnati | |
| Adjunctive Ganaxolone Treatment (Part A) in TSC Followed by Long-term Treatment (Part B) | NCT04285346 | Tuberous Sclero... | Ganaxolone | 2 Years - 65 Years | Marinus Pharmaceuticals | |
| Study of Skin Tumors in Tuberous Sclerosis | NCT00001975 | Tuberous Sclero... | 18 Years - 90 Years | National Institutes of Health Clinical Center (CC) | ||
| Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures | NCT04485104 | Seizure in Part... Seizure in Part... Seizure in Part... | GWP42003-P | 1 Month - 23 Months | Jazz Pharmaceuticals | |
| Long-term Trial of Topical Sirolimus to Angiofibroma in Patient With Tuberous Sclerosis Complex | NCT02634931 | Tuberous Sclero... Angiofibroma Hypomelanotic M... Plaque | NPC-12G gel | 3 Years - | Nobelpharma | |
| Phase III Trial of Topical Formulation of Sirolimus to Skin Lesions in Patients With Tuberous Sclerosis Complex (TSC) | NCT02635789 | Tuberous Sclero... Angiofibroma Hypomelanotic M... Plaque | NPC-12G gel Placebo gel | 3 Years - | Nobelpharma | |
| Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC) | NCT02461459 | Tuberous Sclero... Autism Disorder Intellectual Di... | 18 Months - | Boston Children's Hospital | ||
| Phase III Trial of Topical Formulation of Sirolimus to Skin Lesions in Patients With Tuberous Sclerosis Complex (TSC) | NCT02635789 | Tuberous Sclero... Angiofibroma Hypomelanotic M... Plaque | NPC-12G gel Placebo gel | 3 Years - | Nobelpharma |
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