Spots Global Cancer Trial Database for stage iv intrahepatic cholangiocarcinoma ajcc v8

Every month we try and update this database with for stage iv intrahepatic cholangiocarcinoma ajcc v8 cancer trials from around the world to help patients and their families find trials that might be right for them.
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The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)	NCT05564403	Recurrent Bilia... Recurrent Dista... Recurrent Gallb... Recurrent Intra... Stage III Dista... Stage III Hilar... Stage III Intra... Stage IV Distal... Stage IV Hilar ... Stage IV Intrah... Unresectable Bi... Unresectable Di... Unresectable Ga... Unresectable In...	Binimetinib Biopsy Biospecimen Col... Bone Scan Computed Tomogr... Echocardiograph... Fluorouracil Leucovorin Calc... Magnetic Resona... Multigated Acqu... Oxaliplatin	18 Years -	National Cancer Institute (NCI)
Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies	NCT04068194	Cholangiocarcin... Gallbladder Car... Stage III Gallb... Stage III Hilar... Stage III Intra... Stage IV Gallbl... Stage IV Hilar ... Stage IV Intrah...	Avelumab Biopsy Biospecimen Col... Computed Tomogr... Hypofractionate... Peposertib	18 Years -	National Cancer Institute (NCI)
NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma	NCT06420349	Advanced Cholan... Metastatic Chol... Refractory Chol... Stage III Hilar... Stage III Intra... Stage IV Hilar ... Stage IV Intrah...	Biospecimen Col... Computed Tomogr... Heat Shock Fact... Magnetic Resona... Positron Emissi... Ultrasound-Guid...	18 Years -	Mayo Clinic
Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma	NCT04708067	Locally Advance... Metastatic Intr... Stage III Intra... Stage IIIA Intr... Stage IIIB Intr... Stage IV Intrah...	Bintrafusp Alfa Biopsy Hypofractionate...	18 Years -	M.D. Anderson Cancer Center
Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver	NCT04175912	Metastatic Chol... Metastatic Hepa... Stage III Hepat... Stage III Intra... Stage IIIA Hepa... Stage IIIA Intr... Stage IIIB Hepa... Stage IIIB Intr... Stage IV Hepato... Stage IV Intrah... Stage IVA Hepat... Stage IVB Hepat... Unresectable Ch... Unresectable He... Unresectable In...	Carboplatin Paclitaxel Pevonedistat	18 Years -	National Cancer Institute (NCI)
Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma	NCT06058663	Locally Advance... Oligometastatic... Stage III Intra... Stage IV Intrah... Unresectable In...	Angiography Biopsy Biospecimen Col... Computed Tomogr... Durvalumab Magnetic Resona... Positron Emissi... Tremelimumab Yttrium-90 Micr...	18 Years -	Mayo Clinic
Sacituzumab Govitecan for the Treatment for Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma	NCT06178588	Locally Advance... Metastatic Chol... Recurrent Chola... Stage III Hilar... Stage III Intra... Stage IV Hilar ... Stage IV Intrah...	Biopsy Biospecimen Col... Computed Tomogr... Magnetic Resona... Positron Emissi... Sacituzumab Gov...	18 Years -	University of Kansas Medical Center
Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer	NCT04941287	Metastatic Dist... Metastatic Gall... Metastatic Intr... Recurrent Dista... Recurrent Gallb... Recurrent Intra... Stage IV Distal... Stage IV Gallbl... Stage IV Intrah... Unresectable Li...	Atezolizumab Biopsy Biospecimen Col... Cobimetinib Computed Tomogr... Magnetic Resona... Varlilumab	18 Years -	National Cancer Institute (NCI)
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases	NCT05285358	Distal Bile Duc... Gallbladder Car... Intrahepatic Ch... Metastatic Mali... Stage IV Distal... Stage IV Intrah... Stage IV Intrah... Stage IVB Gallb...	Cisplatin Gemcitabine Nab-paclitaxel Quality-of-Life... Questionnaire A...	18 Years -	City of Hope Medical Center
Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma	NCT06058663	Locally Advance... Oligometastatic... Stage III Intra... Stage IV Intrah... Unresectable In...	Angiography Biopsy Biospecimen Col... Computed Tomogr... Durvalumab Magnetic Resona... Positron Emissi... Tremelimumab Yttrium-90 Micr...	18 Years -	Mayo Clinic
Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers	NCT03768414	Stage III Dista... Stage III Gallb... Stage III Intra... Stage IIIA Dist... Stage IIIA Gall... Stage IIIA Intr... Stage IIIB Dist... Stage IIIB Gall... Stage IIIB Intr... Stage IV Distal... Stage IV Gallbl... Stage IV Intrah... Stage IVA Gallb... Stage IVB Gallb... Unresectable Ex... Unresectable Ga... Unresectable In...	Cisplatin Gemcitabine Hyd... Nab-paclitaxel	18 Years -	SWOG Cancer Research Network
Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma	NCT04708067	Locally Advance... Metastatic Intr... Stage III Intra... Stage IIIA Intr... Stage IIIB Intr... Stage IV Intrah...	Bintrafusp Alfa Biopsy Hypofractionate...	18 Years -	M.D. Anderson Cancer Center
Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)	NCT05564403	Recurrent Bilia... Recurrent Dista... Recurrent Gallb... Recurrent Intra... Stage III Dista... Stage III Hilar... Stage III Intra... Stage IV Distal... Stage IV Hilar ... Stage IV Intrah... Unresectable Bi... Unresectable Di... Unresectable Ga... Unresectable In...	Binimetinib Biopsy Biospecimen Col... Bone Scan Computed Tomogr... Echocardiograph... Fluorouracil Leucovorin Calc... Magnetic Resona... Multigated Acqu... Oxaliplatin	18 Years -	National Cancer Institute (NCI)
Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers	NCT03768414	Stage III Dista... Stage III Gallb... Stage III Intra... Stage IIIA Dist... Stage IIIA Gall... Stage IIIA Intr... Stage IIIB Dist... Stage IIIB Gall... Stage IIIB Intr... Stage IV Distal... Stage IV Gallbl... Stage IV Intrah... Stage IVA Gallb... Stage IVB Gallb... Unresectable Ex... Unresectable Ga... Unresectable In...	Cisplatin Gemcitabine Hyd... Nab-paclitaxel	18 Years -	SWOG Cancer Research Network
Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma	NCT04708067	Locally Advance... Metastatic Intr... Stage III Intra... Stage IIIA Intr... Stage IIIB Intr... Stage IV Intrah...	Bintrafusp Alfa Biopsy Hypofractionate...	18 Years -	M.D. Anderson Cancer Center
NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma	NCT06420349	Advanced Cholan... Metastatic Chol... Refractory Chol... Stage III Hilar... Stage III Intra... Stage IV Hilar ... Stage IV Intrah...	Biospecimen Col... Computed Tomogr... Heat Shock Fact... Magnetic Resona... Positron Emissi... Ultrasound-Guid...	18 Years -	Mayo Clinic
Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer	NCT03942328	Stage III Hepat... Stage III Intra... Stage IV Hepato... Stage IV Intrah... Unresectable He... Unresectable In...	Atezolizumab Bevacizumab External Beam R... Pheresis Pneumococcal 13... Therapeutic Aut...	18 Years -	Mayo Clinic
Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer	NCT04941287	Metastatic Dist... Metastatic Gall... Metastatic Intr... Recurrent Dista... Recurrent Gallb... Recurrent Intra... Stage IV Distal... Stage IV Gallbl... Stage IV Intrah... Unresectable Li...	Atezolizumab Biopsy Biospecimen Col... Cobimetinib Computed Tomogr... Magnetic Resona... Varlilumab	18 Years -	National Cancer Institute (NCI)
mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma	NCT04251715	Liver and Intra... Stage III Intra... Stage IIIA Intr... Stage IIIB Intr... Stage IV Intrah... Unresectable In...	Dexamethasone Floxuridine Implanted Medic... Irinotecan Leucovorin Oxaliplatin Quality-of-Life...	18 Years -	OHSU Knight Cancer Institute
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases	NCT05285358	Distal Bile Duc... Gallbladder Car... Intrahepatic Ch... Metastatic Mali... Stage IV Distal... Stage IV Intrah... Stage IV Intrah... Stage IVB Gallb...	Cisplatin Gemcitabine Nab-paclitaxel Quality-of-Life... Questionnaire A...	18 Years -	City of Hope Medical Center

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