Spots Global Cancer Trial Database for Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
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Trial Identification
Brief Title: Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
Official Title: A Single-Arm Phase-II Study of Niraparib in Locally Advanced or Metastatic Solid Tumor Patients With PALB2 Mutations
Study ID: NCT05169437
Interventions
Study Description
Brief Summary: The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Yuma Regional Medical Center, Yuma, Arizona, United States
Highlands Oncology, Springdale, Arkansas, United States
Memorial Care Medical Center, Fountain Valley, California, United States
St Joseph Heritage Health - Fullerton, Fullerton, California, United States
University of California San Diego, La Jolla, California, United States
MemorialCare, Long Beach, California, United States
Cancer and Blood Specialty Clinic, Los Alamitos, California, United States
Cancer and Blood Specialty, Los Alamitos, California, United States
University of California Los Angeles, Los Angeles, California, United States
St Joseph Health Medical Group - Napa, Napa, California, United States
Ventura County Hematology Oncology Specialists, Oxnard, California, United States
Sharp Healthcare, San Diego, California, United States
Ridley-Tree Cancer Center, Santa Barbara, California, United States
St Joseph Health Medical Group - Santa Rosa, Santa Rosa, California, United States
Hartford Healthcare, Hartford, Connecticut, United States
Eastern Connecticut Hematology and Oncology, Norwich, Connecticut, United States
Holy Cross, Fort Lauderdale, Florida, United States
Cancer Specialists of North Florida, Jacksonville, Florida, United States
Ocala Community Cancer Center, Ocala, Florida, United States
University Cancer & Blood Center, Athens, Georgia, United States
Hawaii Cancer Care, Honolulu, Hawaii, United States
Rush University Medical Center, Chicago, Illinois, United States
Northwest Oncology & Hematology, Rolling Meadows, Illinois, United States
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana, United States
Goshen Health, Goshen, Indiana, United States
Community Health Network, Indianapolis, Indiana, United States
Beacon Health System, South Bend, Indiana, United States
Pontchartrain Cancer Center, Hammond, Louisiana, United States
The Center for Cancer and Blood Disorders - Maryland, Bethesda, Maryland, United States
Frederick Health, Frederick, Maryland, United States
Maryland Oncology Hematology, Rockville, Maryland, United States
Southcoast Health, Fairhaven, Massachusetts, United States
Sparrow Health, Lansing, Michigan, United States
Central Care Cancer Center, Bolivar, Missouri, United States
Mosaic Life Care, Saint Joseph, Missouri, United States
Oncology Hematology Associates, Springfield, Missouri, United States
Nebraska Cancer Specialists, Omaha, Nebraska, United States
OptumCare Cancer Care, Las Vegas, Nevada, United States
New Jersey Cancer Care and Blood Disorders, Belleville, New Jersey, United States
Englewood Health, Englewood, New Jersey, United States
Summit Medical Group, Florham Park, New Jersey, United States
Novant Health Inc. - Charlotte, Charlotte, North Carolina, United States
Southeastern Medical Oncology Center, Goldsboro, North Carolina, United States
Novant Health Inc. - Winston-Salem, Winston-Salem, North Carolina, United States
Aultman Medical Group, Canton, Ohio, United States
TriHealth, Cincinnati, Ohio, United States
University Hospitals Seidman, Cleveland, Ohio, United States
Cleveland Clinic - Taussig Cancer Center, Cleveland, Ohio, United States
OhioHealth, Columbus, Ohio, United States
The Toledo Clinic, Toledo, Ohio, United States
Oklahoma Cancer Specialists, Tulsa, Oklahoma, United States
Oregon Oncology Specialists, Salem, Oregon, United States
Gettysburg Cancer Center, Gettysburg, Pennsylvania, United States
Bon Secours - St. Francis Cancer Center, Greenville, South Carolina, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Sanford Health, Sioux Falls, South Dakota, United States
Baptist Cancer Center, Memphis, Tennessee, United States
Vanderbilt University, Nashville, Tennessee, United States
Texas Oncology - Austin Midtown, Austin, Texas, United States
Texas Oncology - Austin Central Pharmacy, Austin, Texas, United States
Texas Oncology - South Austin, Austin, Texas, United States
Mary Crowley Cancer Research, Dallas, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
The University of Texas Southwestern Medical Center, Dallas, Texas, United States
Oncology Consultants, Houston, Texas, United States
Texas Oncology - Longview Cancer Center, Longview, Texas, United States
Texas Oncology - Palestine Cancer Center, Palestine, Texas, United States
Texas Oncology - Paris Cancer Center, Paris, Texas, United States
Lumi Research, Sugar Land, Texas, United States
Texas Oncology - Tyler Pharmacy, Tyler, Texas, United States
Community Cancer Trials of Utah, Ogden, Utah, United States
Utah Cancer Specialists, Salt Lake City, Utah, United States
Inova Schar Institute, Fairfax, Virginia, United States
Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia, United States
Virginia Cancer Institute, Richmond, Virginia, United States
Virginia Cancer Institute, Richmond, Virginia, United States
PeaceHealth, Bellingham, Washington, United States
Northwest Medical Specialties, Tacoma, Washington, United States
ThedaCare, Appleton, Wisconsin, United States
SSM Health, Madison, Wisconsin, United States
Contact Details
Name: Anjali Avadhani, MD
Affiliation: Tempus AI, Inc.
Role: STUDY_DIRECTOR
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