Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250) NCT04768296 Small-cell Lung...
Berzosertib
Berzosertib
Topotecan
18 Years - EMD Serono View Carboplatin, Gemcitabine Hydrochloride, and Berzosertib in Treating Patients With Recurrent and Metastatic Ovarian, Primary Peritoneal, or Fallopian Tube Cancer NCT02627443 Metastatic Fall...
Metastatic Ovar...
Metastatic Prim...
Ovarian Endomet...
Ovarian High Gr...
Platinum-Sensit...
Recurrent Fallo...
Recurrent Ovari...
Recurrent Prima...
Stage IV Fallop...
Stage IV Ovaria...
Stage IV Primar...
Berzosertib
Carboplatin
Gemcitabine Hyd...
Laboratory Biom...
Pharmacological...
18 Years - National Cancer Institute (NCI) View Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer NCT02567422 Head and Neck C...
Head and Neck S...
Stage III Hypop...
Stage III Laryn...
Stage III Oral ...
Stage III Oroph...
Stage III Sinon...
Stage IV Hypoph...
Stage IV Laryng...
Stage IV Oral C...
Stage IV Oropha...
Stage IV Sinona...
Berzosertib
Cisplatin
Computed Tomogr...
Laboratory Biom...
Magnetic Resona...
Positron Emissi...
Radiation Thera...
18 Years - National Cancer Institute (NCI) View Carboplatin, Gemcitabine Hydrochloride, and Berzosertib in Treating Patients With Recurrent and Metastatic Ovarian, Primary Peritoneal, or Fallopian Tube Cancer NCT02627443 Metastatic Fall...
Metastatic Ovar...
Metastatic Prim...
Ovarian Endomet...
Ovarian High Gr...
Platinum-Sensit...
Recurrent Fallo...
Recurrent Ovari...
Recurrent Prima...
Stage IV Fallop...
Stage IV Ovaria...
Stage IV Primar...
Berzosertib
Carboplatin
Gemcitabine Hyd...
Laboratory Biom...
Pharmacological...
18 Years - National Cancer Institute (NCI) View Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors NCT02589522 Metastatic Lung...
Metastatic Lung...
Metastatic Lung...
Metastatic Mali...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Berzosertib
Quality-of-Life...
Therapeutic Con...
Whole-Brain Rad...
18 Years - National Cancer Institute (NCI) View Gemcitabine Hydrochloride Alone or With M6620 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer NCT02595892 Ovarian Serous ...
Recurrent Fallo...
Recurrent Ovari...
Recurrent Prima...
Berzosertib
Gemcitabine
Gemcitabine Hyd...
18 Years - National Cancer Institute (NCI) View Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer NCT02567409 Metastatic Blad...
Metastatic Rena...
Metastatic Uret...
Stage IV Bladde...
Berzosertib
Cisplatin
Gemcitabine Hyd...
18 Years - National Cancer Institute (NCI) View Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs NCT03896503 Bladder Small C...
Extensive Stage...
Extrapulmonary ...
Limited Stage L...
Platinum-Resist...
Platinum-Sensit...
Prostate Small ...
Recurrent Lung ...
Berzosertib
Biopsy
Biospecimen Col...
Computed Tomogr...
Topotecan Hydro...
18 Years - National Cancer Institute (NCI) View Gemcitabine Hydrochloride Alone or With M6620 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer NCT02595892 Ovarian Serous ...
Recurrent Fallo...
Recurrent Ovari...
Recurrent Prima...
Berzosertib
Gemcitabine
Gemcitabine Hyd...
18 Years - National Cancer Institute (NCI) View Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer NCT03641313 Clinical Stage ...
Clinical Stage ...
Clinical Stage ...
Clinical Stage ...
Metastatic Gast...
Metastatic Gast...
Unresectable Ga...
Unresectable Ga...
Berzosertib
Computed Tomogr...
Endoscopic Biop...
Irinotecan
Magnetic Resona...
18 Years - National Cancer Institute (NCI) View Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs NCT03896503 Bladder Small C...
Extensive Stage...
Extrapulmonary ...
Limited Stage L...
Platinum-Resist...
Platinum-Sensit...
Prostate Small ...
Recurrent Lung ...
Berzosertib
Biopsy
Biospecimen Col...
Computed Tomogr...
Topotecan Hydro...
18 Years - National Cancer Institute (NCI) View Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250) NCT04768296 Small-cell Lung...
Berzosertib
Berzosertib
Topotecan
18 Years - EMD Serono View Berzosertib Human Mass Balance Study (DDRiver Solid Tumors 208) NCT05246111 Advanced Solid ...
[14C]M6620
M6620
Topotecan
18 Years - Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany View Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors NCT04266912 Metastatic Mali...
Refractory Mali...
Unresectable Ma...
Avelumab
Berzosertib
18 Years - M.D. Anderson Cancer Center View M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery NCT02595931 Metastatic Colo...
Metastatic Lung...
Metastatic Mali...
Metastatic Panc...
Refractory Colo...
Refractory Lung...
Refractory Mali...
Refractory Panc...
Stage III Color...
Stage III Lung ...
Stage III Pancr...
Stage IV Colore...
Stage IV Lung C...
Stage IV Pancre...
Unresectable Co...
Unresectable Lu...
Unresectable Ma...
Unresectable Pa...
Berzosertib
Biopsy Specimen
Biospecimen Col...
Computed Tomogr...
Irinotecan Hydr...
18 Years - National Cancer Institute (NCI) View Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer NCT02567422 Head and Neck C...
Head and Neck S...
Stage III Hypop...
Stage III Laryn...
Stage III Oral ...
Stage III Oroph...
Stage III Sinon...
Stage IV Hypoph...
Stage IV Laryng...
Stage IV Oral C...
Stage IV Oropha...
Stage IV Sinona...
Berzosertib
Cisplatin
Computed Tomogr...
Laboratory Biom...
Magnetic Resona...
Positron Emissi...
Radiation Thera...
18 Years - National Cancer Institute (NCI) View M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer NCT03517969 Castration-Resi...
Metastatic Pros...
Stage IV Prosta...
Berzosertib
Carboplatin
Docetaxel
Laboratory Biom...
18 Years - National Cancer Institute (NCI) View Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors NCT02589522 Metastatic Lung...
Metastatic Lung...
Metastatic Lung...
Metastatic Mali...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Berzosertib
Quality-of-Life...
Therapeutic Con...
Whole-Brain Rad...
18 Years - National Cancer Institute (NCI) View Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors NCT02589522 Metastatic Lung...
Metastatic Lung...
Metastatic Lung...
Metastatic Mali...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Berzosertib
Quality-of-Life...
Therapeutic Con...
Whole-Brain Rad...
18 Years - National Cancer Institute (NCI) View Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer NCT02567422 Head and Neck C...
Head and Neck S...
Stage III Hypop...
Stage III Laryn...
Stage III Oral ...
Stage III Oroph...
Stage III Sinon...
Stage IV Hypoph...
Stage IV Laryng...
Stage IV Oral C...
Stage IV Oropha...
Stage IV Sinona...
Berzosertib
Cisplatin
Computed Tomogr...
Laboratory Biom...
Magnetic Resona...
Positron Emissi...
Radiation Thera...
18 Years - National Cancer Institute (NCI) View