Spots Global Cancer Trial Database for intrathecal chemotherapy
Every month we try and update this database with for intrathecal chemotherapy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis | NCT05305885 | Leptomeningeal ... | Pemetrexed Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors | NCT04029688 | Acute Myeloid L... Acute Lymphobla... Neuroblastoma Solid Tumors | Idasanutlin Venetoclax Cyclophosphamid... Topotecan Fludarabine Cytarabine Intrathecal Che... | 0 Years - 30 Years | Hoffmann-La Roche | |
| Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) | NCT01324180 | Acute Lymphobla... | Metformin Vincristine Dexamethasone PEG-asparaginas... Doxorubicin Intrathecal che... | 1 Year - 30 Years | H. Lee Moffitt Cancer Center and Research Institute | |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. | NCT06296745 | Leptomeningeal ... | Pemetrexed | 18 Years - 75 Years | Guangzhou Medical University | |
| Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System | NCT01596127 | Leukemia Lymphoid Malign... Metastatic Mali... | Intrathecal Rit... | 3 Years - | M.D. Anderson Cancer Center | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis | NCT04356222 | Leptomeningeal ... Durvalumab | Durvalumab methotrexate | 18 Years - | Hebei Medical University | |
| Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors | NCT03507244 | Leptomeningeal ... | Pemetrexed Dexamethasone Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma | NCT04903678 | Retinoblastoma,... | Melphalan | - | Eye & ENT Hospital of Fudan University | |
| Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors | NCT03507244 | Leptomeningeal ... | Pemetrexed Dexamethasone Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| CNS Prophylaxis in Diffuse Large B-cell Lymphoma | NCT02777736 | Diffuse Large B... | Methotrexate | 18 Years - 72 Years | Czech Lymphoma Study Group | |
| CNS Prophylaxis in Diffuse Large B-cell Lymphoma | NCT02777736 | Diffuse Large B... | Methotrexate | 18 Years - 72 Years | Czech Lymphoma Study Group | |
| Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis | NCT05305885 | Leptomeningeal ... | Pemetrexed Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis | NCT02590510 | Meningeal Carci... | methotrexate | 14 Years - | Hebei Medical University | |
| Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer | NCT06304441 | Leptomeningeal ... | Osimertinib Pemetrexed | 18 Years - 75 Years | Guangzhou Medical University | |
| Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis | NCT02590510 | Meningeal Carci... | methotrexate | 14 Years - | Hebei Medical University | |
| Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis | NCT04356222 | Leptomeningeal ... Durvalumab | Durvalumab methotrexate | 18 Years - | Hebei Medical University | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) | NCT01324180 | Acute Lymphobla... | Metformin Vincristine Dexamethasone PEG-asparaginas... Doxorubicin Intrathecal che... | 1 Year - 30 Years | H. Lee Moffitt Cancer Center and Research Institute |
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