Spots Global Cancer Trial Database for leptomeningeal metastasis
Every month we try and update this database with for leptomeningeal metastasis cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases | NCT04192981 | Brain Metastase... Leptomeningeal ... | GDC-0084 whole brain rad... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation | NCT04233021 | Non Small Cell ... Leptomeningeal ... Brain Metastase... EGFR Activating... | Osimertinib | 18 Years - | Intergroupe Francophone de Cancerologie Thoracique | |
| Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis | NCT05305885 | Leptomeningeal ... | Pemetrexed Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease | NCT05257967 | EGFR Activating... Leptomeningeal ... Non Small Cell ... | Lumbar puncture... | 18 Years - | British Columbia Cancer Agency | |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. | NCT06296745 | Leptomeningeal ... | Pemetrexed | 18 Years - 75 Years | Guangzhou Medical University | |
| Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis | NCT04148898 | Leptomeningeal ... Non-small Cell ... EGFR Activating... | Osimertinib Bevacizumab | 18 Years - 80 Years | Second Affiliated Hospital of Nanchang University | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer | NCT06058988 | Brain Cancer Glioblastoma Metastatic Canc... Leptomeningeal ... Recurrent Gliob... | Trastuzumab der... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA | NCT00477503 | Central Nervous... Brain Tumors | Gallium-67 Citr... In-111 DTPA (In... | 2 Years - | M.D. Anderson Cancer Center | |
| Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis | NCT04356222 | Leptomeningeal ... Durvalumab | Durvalumab methotrexate | 18 Years - | Hebei Medical University | |
| Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors | NCT03507244 | Leptomeningeal ... | Pemetrexed Dexamethasone Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis | NCT01281696 | Breast Neoplasm... Leptomeningeal ... Brain Metastase... | Bevacizumab, et... Intrathecal met... | 18 Years - 75 Years | National Taiwan University Hospital | |
| Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors | NCT03507244 | Leptomeningeal ... | Pemetrexed Dexamethasone Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer | NCT06431685 | NSCLC Low Dose Radiot... PD-1 Inhibitor Leptomeningeal ... | Whole Brain Low... Pemetrexed Sintilimab Chemotherapy | 18 Years - 75 Years | Sichuan University | |
| A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY) | NCT04778800 | NSCLC Brain Metastase... Leptomeningeal ... | almonertinib LM-first line t... LM-second line ... | 18 Years - | Henan Cancer Hospital | |
| Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors | NCT03082144 | Leptomeningeal ... | MTX Ara-C Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer | NCT05385185 | Leptomeningeal ... Immune Checkpoi... Endostatin | Camrelizumab or... | 18 Years - | Hebei Medical University | |
| DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease | NCT04420598 | Advanced Breast... HER2-positive B... Brain Metastase... Leptomeningeal ... | Trastuzumab der... | 18 Years - | MedSIR | |
| Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir | NCT06399926 | Leptomeningeal ... Lung Cancer | Pemetrexed inje... Pemetrexed | 18 Years - | Xiangya Hospital of Central South University | |
| Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease | NCT05800275 | Leptomeningeal ... Leptomeningeal ... HER2-positive M... | Tucatinib Oral ... Capecitabine ta... Trastuzumab Inj... | 18 Years - | UNICANCER | |
| Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer | NCT06431685 | NSCLC Low Dose Radiot... PD-1 Inhibitor Leptomeningeal ... | Whole Brain Low... Pemetrexed Sintilimab Chemotherapy | 18 Years - 75 Years | Sichuan University | |
| Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases | NCT05034497 | Leptomeningeal ... | 186RNL | 18 Years - | Plus Therapeutics | |
| Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis | NCT05305885 | Leptomeningeal ... | Pemetrexed Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis | NCT04944069 | NSCLC Leptomeningeal ... EGFR Activating... | Almonertinib Bevacizumab | 18 Years - 75 Years | Second Affiliated Hospital of Nanchang University | |
| Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis | NCT01281696 | Breast Neoplasm... Leptomeningeal ... Brain Metastase... | Bevacizumab, et... Intrathecal met... | 18 Years - 75 Years | National Taiwan University Hospital | |
| Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer | NCT04425681 | Leptomeningeal ... Non-small Cell ... EGFR Activating... | Osimertinib Bevacizumab | 18 Years - 80 Years | Second Affiliated Hospital of Nanchang University | |
| Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation | NCT05146219 | NSCLC EGFR Activating... Brain Metastase... Leptomeningeal ... | TY-9591 Tablets | 18 Years - | TYK Medicines, Inc | |
| GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases | NCT04192981 | Brain Metastase... Leptomeningeal ... | GDC-0084 whole brain rad... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma) | NCT04315246 | Leptomeningeal ... Solid Tumor, Ad... | radiolabeled DP... | 18 Years - | Y-mAbs Therapeutics | |
| Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease | NCT04588545 | HER2-positive B... Leptomeningeal ... Leptomeningeal ... | Radiation Thera... Pertuzumab Trastuzumab | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation | NCT05146219 | NSCLC EGFR Activating... Brain Metastase... Leptomeningeal ... | TY-9591 Tablets | 18 Years - | TYK Medicines, Inc | |
| 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma) | NCT04315246 | Leptomeningeal ... Solid Tumor, Ad... | radiolabeled DP... | 18 Years - | Y-mAbs Therapeutics | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide | NCT05414123 | Leptomeningeal ... Leptomeningeal ... Leptomeningeal ... Breast Cancer Non-Small Cell ... | CNSide | - | Biocept, Inc. | |
| A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis | NCT02803619 | Non-small Cell ... Leptomeningeal ... | - | Peking Union Medical College Hospital | ||
| Tomotherapy for Leptomeningeal Metastases | NCT04178343 | Leptomeningeal ... | tomotherapy | 18 Years - 75 Years | ChineseAMS | |
| Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA | NCT00477503 | Central Nervous... Brain Tumors | Gallium-67 Citr... In-111 DTPA (In... | 2 Years - | M.D. Anderson Cancer Center | |
| Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir | NCT06399926 | Leptomeningeal ... Lung Cancer | Pemetrexed inje... Pemetrexed | 18 Years - | Xiangya Hospital of Central South University | |
| Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis | NCT06417710 | Leptomeningeal ... Leptomeningeal ... Leptomeningeal ... Leptomeningeal ... | Neurological As... | 18 Years - | University of Zurich | |
| Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors | NCT03082144 | Leptomeningeal ... | MTX Ara-C Radiotherapy | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. | NCT03974204 | Breast Cancer Leptomeningeal ... | Cerebrospinal f... Cerebrospinal f... Cerebrospinal f... | 18 Years - | Centre Oscar Lambret | |
| Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. | NCT03974204 | Breast Cancer Leptomeningeal ... | Cerebrospinal f... Cerebrospinal f... Cerebrospinal f... | 18 Years - | Centre Oscar Lambret | |
| Intrathecal Double Checkpoint Inhibition | NCT05598853 | Leptomeningeal ... Non-small Cell ... Melanoma Stage ... | intrathecal niv... | 18 Years - 100 Years | University of Zurich | |
| Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. | NCT03974204 | Breast Cancer Leptomeningeal ... | Cerebrospinal f... Cerebrospinal f... Cerebrospinal f... | 18 Years - | Centre Oscar Lambret | |
| Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis | NCT05746754 | Leptomeningeal ... | CSI | 18 Years - | University of Aarhus | |
| Pembrolizumab And Lenvatinib In Leptomeningeal Metastases | NCT04729348 | Solid Tumor Solid Tumor, Ad... Leptomeningeal ... | Pembrolizumab Lenvatinib | 18 Years - | Massachusetts General Hospital | |
| Tomotherapy for Leptomeningeal Metastases | NCT04178343 | Leptomeningeal ... | tomotherapy | 18 Years - 75 Years | ChineseAMS | |
| Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer | NCT06304441 | Leptomeningeal ... | Osimertinib Pemetrexed | 18 Years - 75 Years | Guangzhou Medical University | |
| CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease | NCT05257967 | EGFR Activating... Leptomeningeal ... Non Small Cell ... | Lumbar puncture... | 18 Years - | British Columbia Cancer Agency | |
| Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. | NCT03974204 | Breast Cancer Leptomeningeal ... | Cerebrospinal f... Cerebrospinal f... Cerebrospinal f... | 18 Years - | Centre Oscar Lambret | |
| Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases | NCT05034497 | Leptomeningeal ... | 186RNL | 18 Years - | Plus Therapeutics | |
| Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis | NCT04356222 | Leptomeningeal ... Durvalumab | Durvalumab methotrexate | 18 Years - | Hebei Medical University | |
| Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer | NCT04833205 | Leptomeningeal ... Lung Cancer | Nimotuzumab | 18 Years - | Hebei Medical University | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM) | NCT02071056 | Leptomeningeal ... | 18 Years - | Dartmouth-Hitchcock Medical Center |
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